Expanding the pig metabolomics QTL catalog. Ibragimov, E., Morsing, M. K., Rydal, M. P., Cai, Z., Stenlund, H., Nielsen, J. P., Fredholm, M., & Karlskov-Mortensen, P. Genetics Selection Evolution, 58(1):75, October, 2026.
Paper doi abstract bibtex Understanding the genetic regulation of metabolism is essential for improving animal health and productivity and for strengthening the use of pigs as translational models for human metabolic diseases. Metabolomics, when integrated with genomic data, provides a powerful framework for identifying genetic factors that influence intermediate molecular phenotypes closely linked to physiology. While large-scale metabolomics genome‑wide association studies (GWAS) have been extensively performed in humans, comparable studies in pigs remain limited. Among omics disciplines, metabolomics, the systematic study of metabolites central to physiology, represents the omics layer most closely linked to end-point phenotypes in mammals, such as health and production traits (e.g. growth rate). Metabolite levels are influenced by genetics, diet, and microbiome composition, with human studies showing high heritability and identifying numerous metabolite quantitative trait loci (mQTLs). While such findings have advanced our understanding of disease biology in humans, comparable studies in pigs remain limited.
@article{ibragimov_expanding_2026,
title = {Expanding the pig metabolomics {QTL} catalog},
volume = {58},
issn = {1297-9686},
url = {https://doi.org/10.1186/s12711-026-01095-0},
doi = {10.1186/s12711-026-01095-0},
abstract = {Understanding the genetic regulation of metabolism is essential for improving animal health and productivity and for strengthening the use of pigs as translational models for human metabolic diseases. Metabolomics, when integrated with genomic data, provides a powerful framework for identifying genetic factors that influence intermediate molecular phenotypes closely linked to physiology. While large-scale metabolomics genome‑wide association studies (GWAS) have been extensively performed in humans, comparable studies in pigs remain limited. Among omics disciplines, metabolomics, the systematic study of metabolites central to physiology, represents the omics layer most closely linked to end-point phenotypes in mammals, such as health and production traits (e.g. growth rate). Metabolite levels are influenced by genetics, diet, and microbiome composition, with human studies showing high heritability and identifying numerous metabolite quantitative trait loci (mQTLs). While such findings have advanced our understanding of disease biology in humans, comparable studies in pigs remain limited.},
language = {en},
number = {1},
urldate = {2026-11-05},
journal = {Genetics Selection Evolution},
author = {Ibragimov, Emil and Morsing, Malene Kjelin and Rydal, Martin Peter and Cai, Zexi and Stenlund, Hans and Nielsen, Jens Peter and Fredholm, Merete and Karlskov-Mortensen, Peter},
month = oct,
year = {2026},
pages = {75},
}
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