@article{idro_neuroimmunology_2022,
abstract = {Parasitic infections of the central nervous system are an important cause of morbidity and mortality in Africa. The neurological, cognitive, and psychiatric sequelae of these infections result from a complex interplay between the parasites and the host inflammatory response. Here we review some of the diseases caused by selected parasitic organisms known to infect the nervous system including
Plasmodium falciparum
,
Toxoplasma gondii
,
Trypanosoma brucei
spp., and
Taenia solium
species. For each parasite, we describe the geographical distribution, prevalence, life cycle, and typical clinical symptoms of infection and pathogenesis. We pay particular attention to how the parasites infect the brain and the interaction between each organism and the host immune system. We describe how an understanding of these processes may guide optimal diagnostic and therapeutic strategies to treat these disorders. Finally, we highlight current gaps in our understanding of disease pathophysiology and call for increased interrogation of these often-neglected disorders of the nervous system.},
author = {Idro, Richard and Ogwang, Rodney and Barragan, Antonio and Raimondo, Joseph Valentino and Masocha, Willias},
doi = {10.3389/fimmu.2022.791488},
file = {:Users/jacquelinebracher/Zotero/storage/QM24E3U4/Idro et al. - 2022 - Neuroimmunology of Common Parasitic Infections in .pdf:pdf},
issn = {1664-3224},
journal = {Frontiers in Immunology},
month = {feb},
pages = {791488},
title = {{Neuroimmunology of {\{}Common{\}} {\{}Parasitic{\}} {\{}Infections{\}} in {\{}Africa{\}}}},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2022.791488/full},
volume = {13},
year = {2022}
}

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We pay particular attention to how the parasites infect the brain and the interaction between each organism and the host immune system. We describe how an understanding of these processes may guide optimal diagnostic and therapeutic strategies to treat these disorders. 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