@ARTICLE{Ihrie2011-pd,
  title    = "Persistent sonic hedgehog signaling in adult brain determines
              neural stem cell positional identity",
  author   = "Ihrie, Rebecca A and Shah, Jugal K and Harwell, Corey C and
              Levine, Jacob H and Guinto, Cristina D and Lezameta, Melissa and
              Kriegstein, Arnold R and Alvarez-Buylla, Arturo",
  abstract = "Neural stem cells (NSCs) persist in the subventricular zone (SVZ)
              of the adult brain. Location within this germinal region
              determines the type of neuronal progeny NSCs generate, but the
              mechanism of adult NSC positional specification remains unknown.
              We show that sonic hedgehog (Shh) signaling, resulting in high
              gli1 levels, occurs in the ventral SVZ and is associated with the
              genesis of specific neuronal progeny. Shh is selectively produced
              by a small group of ventral forebrain neurons. Ablation of Shh
              decreases production of ventrally derived neuron types, while
              ectopic activation of this pathway in dorsal NSCs respecifies
              their progeny to deep granule interneurons and calbindin-positive
              periglomerular cells. These results show that Shh is necessary
              and sufficient for the specification of adult ventral NSCs.",
  journal  = "Neuron",
  volume   =  71,
  number   =  2,
  pages    = "250--262",
  month    =  jul,
  year     =  2011,
  language = "en"
}

{"_id":"PBu3xjmPpPisp8G4L","bibbaseid":"ihrie-shah-harwell-levine-guinto-lezameta-kriegstein-alvarezbuylla-persistentsonichedgehogsignalinginadultbraindeterminesneuralstemcellpositionalidentity-2011","author_short":["Ihrie, R. A","Shah, J. K","Harwell, C. C","Levine, J. H","Guinto, C. D","Lezameta, M.","Kriegstein, A. R","Alvarez-Buylla, A."],"bibdata":{"bibtype":"article","type":"article","title":"Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity","author":[{"propositions":[],"lastnames":["Ihrie"],"firstnames":["Rebecca","A"],"suffixes":[]},{"propositions":[],"lastnames":["Shah"],"firstnames":["Jugal","K"],"suffixes":[]},{"propositions":[],"lastnames":["Harwell"],"firstnames":["Corey","C"],"suffixes":[]},{"propositions":[],"lastnames":["Levine"],"firstnames":["Jacob","H"],"suffixes":[]},{"propositions":[],"lastnames":["Guinto"],"firstnames":["Cristina","D"],"suffixes":[]},{"propositions":[],"lastnames":["Lezameta"],"firstnames":["Melissa"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Alvarez-Buylla"],"firstnames":["Arturo"],"suffixes":[]}],"abstract":"Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines the type of neuronal progeny NSCs generate, but the mechanism of adult NSC positional specification remains unknown. We show that sonic hedgehog (Shh) signaling, resulting in high gli1 levels, occurs in the ventral SVZ and is associated with the genesis of specific neuronal progeny. Shh is selectively produced by a small group of ventral forebrain neurons. Ablation of Shh decreases production of ventrally derived neuron types, while ectopic activation of this pathway in dorsal NSCs respecifies their progeny to deep granule interneurons and calbindin-positive periglomerular cells. These results show that Shh is necessary and sufficient for the specification of adult ventral NSCs.","journal":"Neuron","volume":"71","number":"2","pages":"250–262","month":"July","year":"2011","language":"en","bibtex":"@ARTICLE{Ihrie2011-pd,\n title = \"Persistent sonic hedgehog signaling in adult brain determines\n neural stem cell positional identity\",\n author = \"Ihrie, Rebecca A and Shah, Jugal K and Harwell, Corey C and\n Levine, Jacob H and Guinto, Cristina D and Lezameta, Melissa and\n Kriegstein, Arnold R and Alvarez-Buylla, Arturo\",\n abstract = \"Neural stem cells (NSCs) persist in the subventricular zone (SVZ)\n of the adult brain. Location within this germinal region\n determines the type of neuronal progeny NSCs generate, but the\n mechanism of adult NSC positional specification remains unknown.\n We show that sonic hedgehog (Shh) signaling, resulting in high\n gli1 levels, occurs in the ventral SVZ and is associated with the\n genesis of specific neuronal progeny. Shh is selectively produced\n by a small group of ventral forebrain neurons. Ablation of Shh\n decreases production of ventrally derived neuron types, while\n ectopic activation of this pathway in dorsal NSCs respecifies\n their progeny to deep granule interneurons and calbindin-positive\n periglomerular cells. These results show that Shh is necessary\n and sufficient for the specification of adult ventral NSCs.\",\n journal = \"Neuron\",\n volume = 71,\n number = 2,\n pages = \"250--262\",\n month = jul,\n year = 2011,\n language = \"en\"\n}\n\n","author_short":["Ihrie, R. A","Shah, J. K","Harwell, C. C","Levine, J. H","Guinto, C. D","Lezameta, M.","Kriegstein, A. R","Alvarez-Buylla, A."],"key":"Ihrie2011-pd","id":"Ihrie2011-pd","bibbaseid":"ihrie-shah-harwell-levine-guinto-lezameta-kriegstein-alvarezbuylla-persistentsonichedgehogsignalinginadultbraindeterminesneuralstemcellpositionalidentity-2011","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["persistent","sonic","hedgehog","signaling","adult","brain","determines","neural","stem","cell","positional","identity","ihrie","shah","harwell","levine","guinto","lezameta","kriegstein","alvarez-buylla"],"title":"Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity","year":2011}