@article{ isingrini_altered_2011,
  title = {Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: {UCMS} causes relaxation impairment to {ACh}},
  volume = {103},
  issn = {1873-507X},
  shorttitle = {Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice},
  doi = {10.1016/j.physbeh.2011.04.002},
  abstract = {Major depression is an independent risk factor for the development of cardiovascular disease. This impact of depression on vascular function seems to be mediated by the endothelial dysfunction, defined as an impairment of endothelium-dependent vasorelaxation, which represents a reliable predictor of atherosclerosis and has been regularly found to be associated with depression. This study aimed at investigating aortic vascular reactivity in mice submitted to the unpredictable chronic mild stress (UCMS) procedure, a reliable model of depression. The results confirm the effectiveness of the UCMS procedure to induce neuroendocrine, physical and behavioral depression-like alterations as well as a significant decrease of acetylcholine-induced vasorelaxation without any effect on phenylephrine-induced vasoconstriction. In this study, we reveal an altered vascular reactivity in an animal model of depression, demonstrating an endothelial dysfunction reminiscent to the one found in depressed patients.},
  language = {eng},
  number = {5},
  journal = {Physiology \& Behavior},
  author = {Isingrini, Elsa and Surget, Alexandre and Belzung, Catherine and Freslon, Jean-Louis and Frisbee, Jefferson and O'Donnell, James and Camus, Vincent and d'Audiffret, Alexandre},
  month = {July},
  year = {2011},
  pmid = {21504753},
  keywords = {Acetylcholine, Animals, Aorta, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Mice, Mice, Inbred BALB C, Phenylephrine, Stress, Psychological, Vasoconstriction, Vasodilation},
  pages = {540--546}
}

{"_id":"8iMDNEbcfXBeXHzvb","authorIDs":[],"author_short":["Isingrini, E.","Surget, A.","Belzung, C.","Freslon, J.","Frisbee, J.","O'Donnell, J.","Camus, V.","d'Audiffret, A."],"bibbaseid":"isingrini-surget-belzung-freslon-frisbee-odonnell-camus-daudiffret-alteredaorticvascularreactivityintheunpredictablechronicmildstressmodelofdepressioninmiceucmscausesrelaxationimpairmenttoach-2011","bibdata":{"abstract":"Major depression is an independent risk factor for the development of cardiovascular disease. This impact of depression on vascular function seems to be mediated by the endothelial dysfunction, defined as an impairment of endothelium-dependent vasorelaxation, which represents a reliable predictor of atherosclerosis and has been regularly found to be associated with depression. This study aimed at investigating aortic vascular reactivity in mice submitted to the unpredictable chronic mild stress (UCMS) procedure, a reliable model of depression. The results confirm the effectiveness of the UCMS procedure to induce neuroendocrine, physical and behavioral depression-like alterations as well as a significant decrease of acetylcholine-induced vasorelaxation without any effect on phenylephrine-induced vasoconstriction. In this study, we reveal an altered vascular reactivity in an animal model of depression, demonstrating an endothelial dysfunction reminiscent to the one found in depressed patients.","author":["Isingrini, Elsa","Surget, Alexandre","Belzung, Catherine","Freslon, Jean-Louis","Frisbee, Jefferson","O'Donnell, James","Camus, Vincent","d'Audiffret, Alexandre"],"author_short":["Isingrini, E.","Surget, A.","Belzung, C.","Freslon, J.","Frisbee, J.","O'Donnell, J.","Camus, V.","d'Audiffret, A."],"bibtex":"@article{ isingrini_altered_2011,\n title = {Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: {UCMS} causes relaxation impairment to {ACh}},\n volume = {103},\n issn = {1873-507X},\n shorttitle = {Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice},\n doi = {10.1016/j.physbeh.2011.04.002},\n abstract = {Major depression is an independent risk factor for the development of cardiovascular disease. This impact of depression on vascular function seems to be mediated by the endothelial dysfunction, defined as an impairment of endothelium-dependent vasorelaxation, which represents a reliable predictor of atherosclerosis and has been regularly found to be associated with depression. This study aimed at investigating aortic vascular reactivity in mice submitted to the unpredictable chronic mild stress (UCMS) procedure, a reliable model of depression. The results confirm the effectiveness of the UCMS procedure to induce neuroendocrine, physical and behavioral depression-like alterations as well as a significant decrease of acetylcholine-induced vasorelaxation without any effect on phenylephrine-induced vasoconstriction. In this study, we reveal an altered vascular reactivity in an animal model of depression, demonstrating an endothelial dysfunction reminiscent to the one found in depressed patients.},\n language = {eng},\n number = {5},\n journal = {Physiology \\& Behavior},\n author = {Isingrini, Elsa and Surget, Alexandre and Belzung, Catherine and Freslon, Jean-Louis and Frisbee, Jefferson and O'Donnell, James and Camus, Vincent and d'Audiffret, Alexandre},\n month = {July},\n year = {2011},\n pmid = {21504753},\n keywords = {Acetylcholine, Animals, Aorta, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Mice, Mice, Inbred BALB C, Phenylephrine, Stress, Psychological, Vasoconstriction, Vasodilation},\n pages = {540--546}\n}","bibtype":"article","doi":"10.1016/j.physbeh.2011.04.002","id":"isingrini_altered_2011","issn":"1873-507X","journal":"Physiology \\& Behavior","key":"isingrini_altered_2011","keywords":"Acetylcholine, Animals, Aorta, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Mice, Mice, Inbred BALB C, Phenylephrine, Stress, Psychological, Vasoconstriction, Vasodilation","language":"eng","month":"July","number":"5","pages":"540--546","pmid":"21504753","shorttitle":"Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice","title":"Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh","type":"article","volume":"103","year":"2011","bibbaseid":"isingrini-surget-belzung-freslon-frisbee-odonnell-camus-daudiffret-alteredaorticvascularreactivityintheunpredictablechronicmildstressmodelofdepressioninmiceucmscausesrelaxationimpairmenttoach-2011","role":"author","urls":{},"keyword":["Acetylcholine","Animals","Aorta","Behavior","Animal","Corticosterone","Depression","Disease Models","Animal","Dose-Response Relationship","Drug","Male","Mice","Mice","Inbred BALB C","Phenylephrine","Stress","Psychological","Vasoconstriction","Vasodilation"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/users/1159944/collections/M6TABHZN/items?key=1pvuA2LY3hAaGNWuGNZF2QkP&format=bibtex&limit=100","creationDate":"2015-02-11T08:49:20.017Z","downloads":0,"keywords":["acetylcholine","animals","aorta","behavior","animal","corticosterone","depression","disease models","animal","dose-response relationship","drug","male","mice","mice","inbred balb c","phenylephrine","stress","psychological","vasoconstriction","vasodilation"],"search_terms":["altered","aortic","vascular","reactivity","unpredictable","chronic","mild","stress","model","depression","mice","ucms","causes","relaxation","impairment","ach","isingrini","surget","belzung","freslon","frisbee","o'donnell","camus","d'audiffret"],"title":"Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh","year":2011,"dataSources":["Jekqva3EtgNgLZ4ic"]}