Functional neuroimaging provides evidence of anomalous cerebral laterality in adults with Klinefelter's syndrome. Itti, E., Gonzalo, I.&nbsp;T.<nbsp>G., Boone, K.&nbsp;B., Geschwind, D.&nbsp;H., Berman, N., Pawlikowska-Haddal, A., Itti, L., Mishkin, F.&nbsp;S., & Swerdloff, R.&nbsp;S. Annals of Neurology, 54(5):669-673, Department of Nuclear Medicine, Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA., Nov, 2003.
abstract   bibtex   
This study aimed to characterize cerebral perfusion in men with Klinefelter's syndrome, known to present specific deficits in language, using (99m)Tc- hexamethylpropylene-amine-oxime scintigraphy and Talairach normalization. While a perfusion asymmetry toward the left hemisphere was found in controls, perfusion was mostly symmetrical in Klinefelter patients in the upper temporal and lower parietal areas. Scores on verbal tests were inversely correlated with perfusion changes, providing neurobiological substrate of anomalous cerebral laterality.
@article{ Itti_etal03an,
  author = {E. Itti and I. T. Gaw Gonzalo and K. B. Boone and D. H. Geschwind
and N. Berman and A. Pawlikowska-Haddal and L. Itti and F. S. Mishkin and
R. S. Swerdloff},
  title = {Functional neuroimaging provides evidence of anomalous cerebral
laterality in adults with Klinefelter's syndrome},
  journal = {Annals of Neurology},
  volume = {54},
  number = {5},
  pages = {669-673},
  month = {Nov},
  year = {2003},
  abstract = {This study aimed to characterize cerebral perfusion in men with
Klinefelter's syndrome, known to present specific deficits in language,
using (99m)Tc- hexamethylpropylene-amine-oxime scintigraphy and Talairach
normalization. While a perfusion asymmetry toward the left hemisphere was
found in controls, perfusion was mostly symmetrical in Klinefelter patients
in the upper temporal and lower parietal areas. Scores on verbal tests were
inversely correlated with perfusion changes, providing neurobiological
substrate of anomalous cerebral laterality.},
  keywords = {},
  address = {Department of Nuclear Medicine, Harbor-UCLA Medical Center, Research
and Education Institute, Torrance, CA.},
  note = {},
  type = { med },
  file = { http://iLab.usc.edu/publications/doc/Itti_etal03an.pdf },
  if = {2002 impact factor: 8.603}
}

Downloads: 0