Postinfectious encephalitis: A coregistered SPECT and magnetic resonance imaging study. Itti, E., Huff, K., Cornford, M. E., Itti, L., Poruri, K., & Mishkin, F. S. Clinical Nuclear Medicine, 27(2):129-130, Feb, 2002.
abstract   bibtex   
An 11-year-old boy was hospitalized for acute headaches, lethargy, and left hemiparesis. A lumbar puncture showed polymorphonuclear leukocytes, but cultures re-mained negative. Flow-attenuated inversion recovery magnetic resonance imaging (MRI) was performed, as was brain SPECT using Tc-99m hexamethylpropylene amineoxime (HMPAO). Anatomic and functional images were coregistered using a unique surface-matching technique. Subsequently, biopsy of a large right frontal lobe lesion was performed. Pathologic examination and electron microscopy showed degeneration of cortical neurons and associated arenavirus-like particles. Whether this caused the disease or represented release by dying neurons of previously present particles remains uncertain.
@article{ Itti_etal02cnm,
  author = {E. Itti and K. Huff and M. E. Cornford and L. Itti and K. Poruri
and F. S. Mishkin},
  title = {Postinfectious encephalitis: A coregistered SPECT and magnetic 
resonance imaging study},
  abstract = {An 11-year-old boy was hospitalized for acute headaches,
lethargy, and left hemiparesis. A lumbar puncture showed
polymorphonuclear leukocytes, but cultures re-mained
negative. Flow-attenuated inversion recovery magnetic resonance
imaging (MRI) was performed, as was brain SPECT using Tc-99m
hexamethylpropylene amineoxime (HMPAO). Anatomic and functional images
were coregistered using a unique surface-matching
technique. Subsequently, biopsy of a large right frontal lobe lesion
was performed. Pathologic examination and electron microscopy showed
degeneration of cortical neurons and associated arenavirus-like
particles. Whether this caused the disease or represented release by
dying neurons of previously present particles remains uncertain. },
  keywords = { Arenavirus ; Brain SPECT ; Coregistration ; Encephalitis },
  journal = {Clinical Nuclear Medicine},
  volume = {27},
  number = {2},
  year = {2002},
  month = {Feb},
  pages = {129-130},
  file = { http://iLab.usc.edu/publications/doc/Itti_etal02cnm.pdf },
  type = {med},
  if = {2000 impact factor: 0.399}
}

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