Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice. Jaber, S. M, Hankenson, F C., Heng, K., McKinstry-Wu, A., Kelz, M. B, & Marx, J. O J Am Assoc Lab Anim Sci, 53(6):684–91, November, 2014. abstract bibtex Extending a surgical plane of anesthesia in mice by using injectable anesthetics typically is accomplished by repeat-bolus dosing. We compared the safety and efficacy of redosing protocols administered either during an anesthetic surgical plane (maintaining a continuous surgical plane, CSP), or immediately after leaving this plane (interrupted surgical plane, ISP) in C57BL/6J mice. Anesthesia was induced with ketamine, xylazine, and acepromazine (80, 8, and 1 mg/kg IP, respectively), and redosing protocols included 25% (0.25K), 50% (0.5K), or 100% (1.0K) of the initial ketamine dose or 25% (0.25KX) or 50% (0.5KX) of the initial ketamine-xylazine dose. In the ISP group, the surgical plane was extended by 13.8 \${\textbackslash}pm\$ 2.1 min (mean \${\textbackslash}pm\$ SEM) after redosing for the 0.25K redose with 50% returning to a surgical plane, 42.7 \${\textbackslash}pm\$ 4.5 min for the 0.5K redose with 88% returning to a surgical plane, and 44.3 \${\textbackslash}pm\$ 15.4 min for the 1.0K redose, 52.8 \${\textbackslash}pm\$ 7.2 min for the 0.25KX redose, and 45.9 \${\textbackslash}pm\$ 2.9 min for the 0.5KX redose, with 100% of mice returning to a surgical plane of anesthesia in these 3 groups. Mortality rates for ISP groups were 0%, 12%, 33%, 12%, and 18%, respectively. Mice in CSP groups had 50% mortality, independent of the repeat-dosing protocol. We recommend redosing mice with either 50% of the initial ketamine dose or 25% of the initial ketamine-xylazine dose immediately upon return of the pedal withdrawal reflex to extend the surgical plane of anesthesia in mice, optimize the extension of the surgical plane, and minimize mortality.
@article{jaber_dose_2014,
title = {Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice},
volume = {53},
abstract = {Extending a surgical plane of anesthesia in mice by using injectable anesthetics typically is accomplished by repeat-bolus dosing. We compared the safety and efficacy of redosing protocols administered either during an anesthetic surgical plane (maintaining a continuous surgical plane, CSP), or immediately after leaving this plane (interrupted surgical plane, ISP) in C57BL/6J mice. Anesthesia was induced with ketamine, xylazine, and acepromazine (80, 8, and 1 mg/kg IP, respectively), and redosing protocols included 25\% (0.25K), 50\% (0.5K), or 100\% (1.0K) of the initial ketamine dose or 25\% (0.25KX) or 50\% (0.5KX) of the initial ketamine-xylazine dose. In the ISP group, the surgical plane was extended by 13.8 \${\textbackslash}pm\$ 2.1 min (mean \${\textbackslash}pm\$ SEM) after redosing for the 0.25K redose with 50\% returning to a surgical plane, 42.7 \${\textbackslash}pm\$ 4.5 min for the 0.5K redose with 88\% returning to a surgical plane, and 44.3 \${\textbackslash}pm\$ 15.4 min for the 1.0K redose, 52.8 \${\textbackslash}pm\$ 7.2 min for the 0.25KX redose, and 45.9 \${\textbackslash}pm\$ 2.9 min for the 0.5KX redose, with 100\% of mice returning to a surgical plane of anesthesia in these 3 groups. Mortality rates for ISP groups were 0\%, 12\%, 33\%, 12\%, and 18\%, respectively. Mice in CSP groups had 50\% mortality, independent of the repeat-dosing protocol. We recommend redosing mice with either 50\% of the initial ketamine dose or 25\% of the initial ketamine-xylazine dose immediately upon return of the pedal withdrawal reflex to extend the surgical plane of anesthesia in mice, optimize the extension of the surgical plane, and minimize mortality.},
number = {6},
journal = {J Am Assoc Lab Anim Sci},
author = {Jaber, Samer M and Hankenson, F Claire and Heng, Kathleen and McKinstry-Wu, Andrew and Kelz, Max B and Marx, James O},
month = nov,
year = {2014},
pmid = {25650976},
keywords = {LAS-biblio, LAS-formations-M2RAPC-BEA, LAS-vet},
pages = {684--91}
}
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O"],"year":2014,"bibtype":"article","biburl":"https://api.zotero.org/groups/1431296/items?key=ZnxDq2qtnrn6EWXf05ukDk6P&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice","volume":"53","abstract":"Extending a surgical plane of anesthesia in mice by using injectable anesthetics typically is accomplished by repeat-bolus dosing. We compared the safety and efficacy of redosing protocols administered either during an anesthetic surgical plane (maintaining a continuous surgical plane, CSP), or immediately after leaving this plane (interrupted surgical plane, ISP) in C57BL/6J mice. Anesthesia was induced with ketamine, xylazine, and acepromazine (80, 8, and 1 mg/kg IP, respectively), and redosing protocols included 25% (0.25K), 50% (0.5K), or 100% (1.0K) of the initial ketamine dose or 25% (0.25KX) or 50% (0.5KX) of the initial ketamine-xylazine dose. In the ISP group, the surgical plane was extended by 13.8 \\${\\textbackslash}pm\\$ 2.1 min (mean \\${\\textbackslash}pm\\$ SEM) after redosing for the 0.25K redose with 50% returning to a surgical plane, 42.7 \\${\\textbackslash}pm\\$ 4.5 min for the 0.5K redose with 88% returning to a surgical plane, and 44.3 \\${\\textbackslash}pm\\$ 15.4 min for the 1.0K redose, 52.8 \\${\\textbackslash}pm\\$ 7.2 min for the 0.25KX redose, and 45.9 \\${\\textbackslash}pm\\$ 2.9 min for the 0.5KX redose, with 100% of mice returning to a surgical plane of anesthesia in these 3 groups. Mortality rates for ISP groups were 0%, 12%, 33%, 12%, and 18%, respectively. Mice in CSP groups had 50% mortality, independent of the repeat-dosing protocol. We recommend redosing mice with either 50% of the initial ketamine dose or 25% of the initial ketamine-xylazine dose immediately upon return of the pedal withdrawal reflex to extend the surgical plane of anesthesia in mice, optimize the extension of the surgical plane, and minimize mortality.","number":"6","journal":"J Am Assoc Lab Anim Sci","author":[{"propositions":[],"lastnames":["Jaber"],"firstnames":["Samer","M"],"suffixes":[]},{"propositions":[],"lastnames":["Hankenson"],"firstnames":["F","Claire"],"suffixes":[]},{"propositions":[],"lastnames":["Heng"],"firstnames":["Kathleen"],"suffixes":[]},{"propositions":[],"lastnames":["McKinstry-Wu"],"firstnames":["Andrew"],"suffixes":[]},{"propositions":[],"lastnames":["Kelz"],"firstnames":["Max","B"],"suffixes":[]},{"propositions":[],"lastnames":["Marx"],"firstnames":["James","O"],"suffixes":[]}],"month":"November","year":"2014","pmid":"25650976","keywords":"LAS-biblio, LAS-formations-M2RAPC-BEA, LAS-vet","pages":"684–91","bibtex":"@article{jaber_dose_2014,\n\ttitle = {Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice},\n\tvolume = {53},\n\tabstract = {Extending a surgical plane of anesthesia in mice by using injectable anesthetics typically is accomplished by repeat-bolus dosing. 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In the ISP group, the surgical plane was extended by 13.8 \\${\\textbackslash}pm\\$ 2.1 min (mean \\${\\textbackslash}pm\\$ SEM) after redosing for the 0.25K redose with 50\\% returning to a surgical plane, 42.7 \\${\\textbackslash}pm\\$ 4.5 min for the 0.5K redose with 88\\% returning to a surgical plane, and 44.3 \\${\\textbackslash}pm\\$ 15.4 min for the 1.0K redose, 52.8 \\${\\textbackslash}pm\\$ 7.2 min for the 0.25KX redose, and 45.9 \\${\\textbackslash}pm\\$ 2.9 min for the 0.5KX redose, with 100\\% of mice returning to a surgical plane of anesthesia in these 3 groups. Mortality rates for ISP groups were 0\\%, 12\\%, 33\\%, 12\\%, and 18\\%, respectively. Mice in CSP groups had 50\\% mortality, independent of the repeat-dosing protocol. 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