Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. Jackson, D. J., Bacharier, L. B., Mauger, D. T., Boehmer, S., Beigelman, A., Chmiel, J. F., Fitzpatrick, A. M., Gaffin, J. M., Morgan, W. J., Peters, S. P., Phipatanakul, W., Sheehan, W. J., Cabana, M. D., Holguin, F., Martinez, F. D., Pongracic, J. A., Baxi, S. N., Benson, M., Blake, K., Covar, R., Gentile, D. A., Israel, E., Krishnan, J. A., Kumar, H. V., Lang, J. E., Lazarus, S. C., Lima, J. J., Long, D., Ly, N., Marbin, J., Moy, J. N., Myers, R. E., Olin, J. T., Raissy, H. H., Robison, R. G., Ross, K., Sorkness, C. A., & Lemanske, R. F. New England Journal of Medicine, 0(0):null, March, 2018.
Paper doi abstract bibtex Inhaled Glucocorticoid Dose and Asthma Exacerbations Increases in symptoms may occur before exacerbations fully develop. In two trials, when symptoms occurred, the dose of inhaled glucocorticoids was increased by a factor of 5 (pediatric trial) or 4 (adult trial). There was no benefit, and perhaps some harm, in children, and a modest benefit in adults.
@article{jackson_quintupling_2018,
title = {Quintupling {Inhaled} {Glucocorticoids} to {Prevent} {Childhood} {Asthma} {Exacerbations}},
volume = {0},
issn = {0028-4793},
url = {http://dx.doi.org/10.1056/NEJMoa1710988},
doi = {10.1056/NEJMoa1710988},
abstract = {Inhaled Glucocorticoid Dose and Asthma Exacerbations Increases in symptoms may occur before exacerbations fully develop. In two trials, when symptoms occurred, the dose of inhaled glucocorticoids was increased by a factor of 5 (pediatric trial) or 4 (adult trial). There was no benefit, and perhaps some harm, in children, and a modest benefit in adults.},
number = {0},
urldate = {2018-03-06},
journal = {New England Journal of Medicine},
author = {Jackson, Daniel J. and Bacharier, Leonard B. and Mauger, David T. and Boehmer, Susan and Beigelman, Avraham and Chmiel, James F. and Fitzpatrick, Anne M. and Gaffin, Jonathan M. and Morgan, Wayne J. and Peters, Stephen P. and Phipatanakul, Wanda and Sheehan, William J. and Cabana, Michael D. and Holguin, Fernando and Martinez, Fernando D. and Pongracic, Jacqueline A. and Baxi, Sachin N. and Benson, Mindy and Blake, Kathryn and Covar, Ronina and Gentile, Deborah A. and Israel, Elliot and Krishnan, Jerry A. and Kumar, Harsha V. and Lang, Jason E. and Lazarus, Stephen C. and Lima, John J. and Long, Dayna and Ly, Ngoc and Marbin, Jyothi and Moy, James N. and Myers, Ross E. and Olin, J. Tod and Raissy, Hengameh H. and Robison, Rachel G. and Ross, Kristie and Sorkness, Christine A. and Robert F. Lemanske, Jr.},
month = mar,
year = {2018},
pmid = {29504498},
pages = {null},
}
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