Study of unipolar electrogram morphology in a computer model of atrial fibrillation. Jacquemet, V., Virag, N., Ihara, Z., Dang, L., Blanc, O., Zozor, S., Vesin, J., Kappenberger, L., & Henriquez, C. *j-JCE*, 14(10 Suppl):S172–S179, 2003. bibtex @Article{RSM:Jac2003,
author = "V. Jacquemet and N. Virag and Z. Ihara and L. Dang and
O. Blanc and S. Zozor and J.M. Vesin and L.
Kappenberger and C.S. Henriquez",
title = "Study of unipolar electrogram morphology in a computer
model of atrial fibrillation.",
journal = j-JCE,
year = "2003",
volume = "14",
number = "10 Suppl",
pages = "S172--S179",
robnote = "INTRODUCTION: In this study, data from computer models
were studied to relate features of the signals to the
underlying dynamics and tissue substrate. METHODS AND
RESULTS: A computer model of entire human atria with a
gross fiber architecture based on histology and
membrane kinetics based on the Courtemanche et al.
atrial model was developed to simulate paced activation
and simulated AF. Unipolar electrograms were computed
using a current source approximation at 256 sites in
right atrium, to simulate a mapping array. The results
show the following: (1) In a homogeneous and isotropic
tissue, the presence of highly asymmetric electrograms
is rare (<2\%), although there is a marked variability
in amplitude and symmetry. (2) The introduction of
anisotropy increases this variability in symmetry and
amplitude of the, electrograms especially for
propagation across fibers. The percentage of highly
asymmetric electrograms increases to 12\% to 15\% for
anisotropy ratios greater than 3:1. (3) Multiphasic and
fractionated electrograms are rarely seen in the model
with uniform properties but are more common (15\%-17\%)
in a model including regions with abrupt changes in
conductivity. Beat-to-beat variations in the occurrence
of multiphasic signals are possible with fixed anatomic
heterogeneity, due to beat-to-beat variations in the
direction of the wavefront relative to the
heterogeneity. CONCLUSION: Analysis of the amplitude
and symmetry of unipolar atrial electrograms can
provide information about the electrophysiologic
substrate maintaining AF.",
bibdate = "Mon Nov 20 07:50:07 2006",
}

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{"_id":"AevZB83tmaD8hGsvo","bibbaseid":"jacquemet-virag-ihara-dang-blanc-zozor-vesin-kappenberger-etal-studyofunipolarelectrogrammorphologyinacomputermodelofatrialfibrillation-2003","downloads":0,"creationDate":"2016-07-01T21:38:35.247Z","title":"Study of unipolar electrogram morphology in a computer model of atrial fibrillation.","author_short":["Jacquemet, V.","Virag, N.","Ihara, Z.","Dang, L.","Blanc, O.","Zozor, S.","Vesin, J.","Kappenberger, L.","Henriquez, C."],"year":2003,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["V."],"propositions":[],"lastnames":["Jacquemet"],"suffixes":[]},{"firstnames":["N."],"propositions":[],"lastnames":["Virag"],"suffixes":[]},{"firstnames":["Z."],"propositions":[],"lastnames":["Ihara"],"suffixes":[]},{"firstnames":["L."],"propositions":[],"lastnames":["Dang"],"suffixes":[]},{"firstnames":["O."],"propositions":[],"lastnames":["Blanc"],"suffixes":[]},{"firstnames":["S."],"propositions":[],"lastnames":["Zozor"],"suffixes":[]},{"firstnames":["J.M."],"propositions":[],"lastnames":["Vesin"],"suffixes":[]},{"firstnames":["L."],"propositions":[],"lastnames":["Kappenberger"],"suffixes":[]},{"firstnames":["C.S."],"propositions":[],"lastnames":["Henriquez"],"suffixes":[]}],"title":"Study of unipolar electrogram morphology in a computer model of atrial fibrillation.","journal":"j-JCE","year":"2003","volume":"14","number":"10 Suppl","pages":"S172–S179","robnote":"INTRODUCTION: In this study, data from computer models were studied to relate features of the signals to the underlying dynamics and tissue substrate. METHODS AND RESULTS: A computer model of entire human atria with a gross fiber architecture based on histology and membrane kinetics based on the Courtemanche et al. atrial model was developed to simulate paced activation and simulated AF. Unipolar electrograms were computed using a current source approximation at 256 sites in right atrium, to simulate a mapping array. The results show the following: (1) In a homogeneous and isotropic tissue, the presence of highly asymmetric electrograms is rare (<2%), although there is a marked variability in amplitude and symmetry. (2) The introduction of anisotropy increases this variability in symmetry and amplitude of the, electrograms especially for propagation across fibers. The percentage of highly asymmetric electrograms increases to 12% to 15% for anisotropy ratios greater than 3:1. (3) Multiphasic and fractionated electrograms are rarely seen in the model with uniform properties but are more common (15%-17%) in a model including regions with abrupt changes in conductivity. Beat-to-beat variations in the occurrence of multiphasic signals are possible with fixed anatomic heterogeneity, due to beat-to-beat variations in the direction of the wavefront relative to the heterogeneity. CONCLUSION: Analysis of the amplitude and symmetry of unipolar atrial electrograms can provide information about the electrophysiologic substrate maintaining AF.","bibdate":"Mon Nov 20 07:50:07 2006","bibtex":"@Article{RSM:Jac2003,\n author = \"V. Jacquemet and N. Virag and Z. Ihara and L. Dang and\n O. Blanc and S. Zozor and J.M. Vesin and L.\n Kappenberger and C.S. Henriquez\",\n title = \"Study of unipolar electrogram morphology in a computer\n model of atrial fibrillation.\",\n journal = j-JCE,\n year = \"2003\",\n volume = \"14\",\n number = \"10 Suppl\",\n pages = \"S172--S179\",\n robnote = \"INTRODUCTION: In this study, data from computer models\n were studied to relate features of the signals to the\n underlying dynamics and tissue substrate. METHODS AND\n RESULTS: A computer model of entire human atria with a\n gross fiber architecture based on histology and\n membrane kinetics based on the Courtemanche et al.\n atrial model was developed to simulate paced activation\n and simulated AF. Unipolar electrograms were computed\n using a current source approximation at 256 sites in\n right atrium, to simulate a mapping array. The results\n show the following: (1) In a homogeneous and isotropic\n tissue, the presence of highly asymmetric electrograms\n is rare (<2\\%), although there is a marked variability\n in amplitude and symmetry. (2) The introduction of\n anisotropy increases this variability in symmetry and\n amplitude of the, electrograms especially for\n propagation across fibers. The percentage of highly\n asymmetric electrograms increases to 12\\% to 15\\% for\n anisotropy ratios greater than 3:1. (3) Multiphasic and\n fractionated electrograms are rarely seen in the model\n with uniform properties but are more common (15\\%-17\\%)\n in a model including regions with abrupt changes in\n conductivity. Beat-to-beat variations in the occurrence\n of multiphasic signals are possible with fixed anatomic\n heterogeneity, due to beat-to-beat variations in the\n direction of the wavefront relative to the\n heterogeneity. CONCLUSION: Analysis of the amplitude\n and symmetry of unipolar atrial electrograms can\n provide information about the electrophysiologic\n substrate maintaining AF.\",\n bibdate = \"Mon Nov 20 07:50:07 2006\",\n}\n\n","author_short":["Jacquemet, V.","Virag, N.","Ihara, Z.","Dang, L.","Blanc, O.","Zozor, S.","Vesin, J.","Kappenberger, L.","Henriquez, C."],"key":"RSM:Jac2003","id":"RSM:Jac2003","bibbaseid":"jacquemet-virag-ihara-dang-blanc-zozor-vesin-kappenberger-etal-studyofunipolarelectrogrammorphologyinacomputermodelofatrialfibrillation-2003","role":"author","urls":{},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"search_terms":["study","unipolar","electrogram","morphology","computer","model","atrial","fibrillation","jacquemet","virag","ihara","dang","blanc","zozor","vesin","kappenberger","henriquez"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}