Interaction of G-quadruplexes with nonintercalating duplex-DNA minor groove binding ligands. Jain, A. K & Bhattacharya, S. Bioconjugate chemistry, 22(12):2355–68, December, 2011. ![Interaction of G-quadruplexes with nonintercalating duplex-DNA minor groove binding ligands. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The enzyme telomerase synthesizes the G-rich DNA strands of the telomere and its activity is often associated with cancer. The telomerase may be therefore responsible for the ability of a cancer cell to escape apoptosis. The G-rich DNA sequences often adopt tetra-stranded structure, known as the G-quadruplex DNA (G4-DNA). The stabilization of the telomeric DNA into the G4-DNA structures by small molecules has been the focus of many researchers for the design and development of new anticancer agents. The compounds which stabilize the G-quadruplex in the telomere inhibit the telomerase activity. Besides telomeres, the G4-DNA forming sequences are present in the genomic regions of biological significance including the transcriptional regulatory and promoter regions of several oncogenes. Inducing a G-quadruplex structure within the G-rich promoter sequences is a potential way of achieving selective gene regulation. Several G-quadruplex stabilizing ligands are known. Minor groove binding ligands (MGBLs) interact with the double-helical DNA through the minor grooves sequence-specifically and interfere with several DNA associated processes. These MGBLs when suitably modified switch their preference sometimes from the duplex DNA to G4-DNA and stabilize the G4-DNA as well. Herein, we focus on the recent advances in understanding the G-quadruplex structures, particularly made by the human telomeric ends, and review the results of various investigations of the interaction of designed organic ligands with the G-quadruplex DNA while highlighting the importance of MGBL-G-quadruplex interactions.
@article{Jain2011,
title = {Interaction of {G}-quadruplexes with nonintercalating duplex-{DNA} minor groove binding ligands.},
volume = {22},
issn = {1520-4812},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22074555},
doi = {10.1021/bc200268a},
abstract = {The enzyme telomerase synthesizes the G-rich DNA strands of the telomere and its activity is often associated with cancer. The telomerase may be therefore responsible for the ability of a cancer cell to escape apoptosis. The G-rich DNA sequences often adopt tetra-stranded structure, known as the G-quadruplex DNA (G4-DNA). The stabilization of the telomeric DNA into the G4-DNA structures by small molecules has been the focus of many researchers for the design and development of new anticancer agents. The compounds which stabilize the G-quadruplex in the telomere inhibit the telomerase activity. Besides telomeres, the G4-DNA forming sequences are present in the genomic regions of biological significance including the transcriptional regulatory and promoter regions of several oncogenes. Inducing a G-quadruplex structure within the G-rich promoter sequences is a potential way of achieving selective gene regulation. Several G-quadruplex stabilizing ligands are known. Minor groove binding ligands (MGBLs) interact with the double-helical DNA through the minor grooves sequence-specifically and interfere with several DNA associated processes. These MGBLs when suitably modified switch their preference sometimes from the duplex DNA to G4-DNA and stabilize the G4-DNA as well. Herein, we focus on the recent advances in understanding the G-quadruplex structures, particularly made by the human telomeric ends, and review the results of various investigations of the interaction of designed organic ligands with the G-quadruplex DNA while highlighting the importance of MGBL-G-quadruplex interactions.},
number = {12},
journal = {Bioconjugate chemistry},
author = {Jain, Akash K and Bhattacharya, Santanu},
month = dec,
year = {2011},
pmid = {22074555},
keywords = {\#nosource, Animals, Binding Sites, DNA, DNA: chemistry, DNA: metabolism, G-Quadruplexes, Humans, Ligands, Models, Molecular, Telomere, Telomere: chemistry, Telomere: metabolism},
pages = {2355--68},
}
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