Determinants and implications of mRNA poly(A) tail size – Does this protein make my tail look big?. Jalkanen, A. L., Coleman, S. J., & Wilusz, J. Seminars in Cell & Developmental Biology, 34:24–32, oct, 2014. Paper doi abstract bibtex While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than a simple static entity that marks the 3' end of an mRNA. This could open up new angles of regulation in the post-transcriptional control of gene expression throughout development, differentiation and cancer.
@article{Jalkanen2014,
abstract = {While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than a simple static entity that marks the 3' end of an mRNA. This could open up new angles of regulation in the post-transcriptional control of gene expression throughout development, differentiation and cancer.},
author = {Jalkanen, Aimee L. and Coleman, Stephen J. and Wilusz, Jeffrey},
doi = {10.1016/j.semcdb.2014.05.018},
issn = {10849521},
journal = {Seminars in Cell & Developmental Biology},
keywords = {Deadenylation,Hyperadenylation,MRNA 3' end processing,Poly(A) tail,Polyadenylation},
month = {oct},
pages = {24--32},
pmid = {24910447},
title = {{Determinants and implications of mRNA poly(A) tail size – Does this protein make my tail look big?}},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1084952114001736},
volume = {34},
year = {2014}
}
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