@article{RN331,
   author = {James, G. and Collin, E. and Lawrance, M. and Mueller, A. and Podhorna, J. and Zaremba-Pechmann, L. and Rijnbeek, P. and van der Lei, J. and Avillach, P. and Pedersen, L. and Ansell, D. and Pasqua, A. and Mosseveld, M. and Grosdidier, S. and Gungabissoon, U. and Egger, P. and Stewart, R. and Celis-Morales, C. and Alexander, M. and Novak, G. and Gordon, M. F.},
   title = {Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe},
   journal = {Soc Psychiatry Psychiatr Epidemiol},
   volume = {56},
   number = {3},
   pages = {409-416},
   note = {1433-9285 James, Glen Orcid: 0000-0003-0080-3156 Collin, Estelle Lawrance, Marcus Mueller, Achim Podhorna, Jana Zaremba-Pechmann, Liliana Rijnbeek, Peter van der Lei, Johan Avillach, Paul Pedersen, Lars Ansell, David Pasqua, Alessandro Mosseveld, Mees Grosdidier, Solène Gungabissoon, Usha Egger, Peter Stewart, Robert Celis-Morales, Carlos Alexander, Myriam Novak, Gerald Gordon, Mark Forrest MC_PC_17214/MRC_/Medical Research Council/United Kingdom 115372/emif/ Journal Article Germany 2020/06/05 Soc Psychiatry Psychiatr Epidemiol. 2021 Mar;56(3):409-416. doi: 10.1007/s00127-020-01872-2. Epub 2020 Jun 3.},
   abstract = {PURPOSE: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer's Disease. METHODS: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. RESULTS: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer's disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-D-aspartate blocker memantine in AUH. CONCLUSION: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer's Disease patients from across Europe.},
   keywords = {*Alzheimer Disease/diagnosis/drug therapy
*Electronic Health Records
Europe
Galantamine
Humans
Indans
Italy
Netherlands
Phenylcarbamates
Piperidines
Retrospective Studies
Alzheimer’s disease
Dementia
Epidemiology
Real-world data ,
ISSN = 0933-7954 ,
DOI = 10.1007/s00127-020-01872-2},
   year = {2021},
   type = {Journal Article}
}

{"_id":"NwzuZYetLWyAgBMsK","bibbaseid":"james-collin-lawrance-mueller-podhorna-zarembapechmann-rijnbeek-vanderlei-etal-treatmentpathwayanalysisofnewlydiagnoseddementiapatientsinfourelectronichealthrecorddatabasesineurope-2021","author_short":["James, G.","Collin, E.","Lawrance, M.","Mueller, A.","Podhorna, J.","Zaremba-Pechmann, L.","Rijnbeek, P.","van der Lei, J.","Avillach, P.","Pedersen, L.","Ansell, D.","Pasqua, A.","Mosseveld, M.","Grosdidier, S.","Gungabissoon, U.","Egger, P.","Stewart, R.","Celis-Morales, C.","Alexander, M.","Novak, G.","Gordon, M. F."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["James"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Collin"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Lawrance"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Mueller"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Podhorna"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Zaremba-Pechmann"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Rijnbeek"],"firstnames":["P."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Lei"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Avillach"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Pedersen"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Ansell"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Pasqua"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Mosseveld"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Grosdidier"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Gungabissoon"],"firstnames":["U."],"suffixes":[]},{"propositions":[],"lastnames":["Egger"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Stewart"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Celis-Morales"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Alexander"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Novak"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Gordon"],"firstnames":["M.","F."],"suffixes":[]}],"title":"Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe","journal":"Soc Psychiatry Psychiatr Epidemiol","volume":"56","number":"3","pages":"409-416","note":"1433-9285 James, Glen Orcid: 0000-0003-0080-3156 Collin, Estelle Lawrance, Marcus Mueller, Achim Podhorna, Jana Zaremba-Pechmann, Liliana Rijnbeek, Peter van der Lei, Johan Avillach, Paul Pedersen, Lars Ansell, David Pasqua, Alessandro Mosseveld, Mees Grosdidier, Solène Gungabissoon, Usha Egger, Peter Stewart, Robert Celis-Morales, Carlos Alexander, Myriam Novak, Gerald Gordon, Mark Forrest MC_PC_17214/MRC_/Medical Research Council/United Kingdom 115372/emif/ Journal Article Germany 2020/06/05 Soc Psychiatry Psychiatr Epidemiol. 2021 Mar;56(3):409-416. doi: 10.1007/s00127-020-01872-2. Epub 2020 Jun 3.","abstract":"PURPOSE: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer's Disease. METHODS: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. RESULTS: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer's disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-D-aspartate blocker memantine in AUH. CONCLUSION: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer's Disease patients from across Europe.","keywords":"*Alzheimer Disease/diagnosis/drug therapy *Electronic Health Records Europe Galantamine Humans Indans Italy Netherlands Phenylcarbamates Piperidines Retrospective Studies Alzheimer’s disease Dementia Epidemiology Real-world data , ISSN = 0933-7954 , DOI = 10.1007/s00127-020-01872-2","year":"2021","bibtex":"@article{RN331,\r\n author = {James, G. and Collin, E. and Lawrance, M. and Mueller, A. and Podhorna, J. and Zaremba-Pechmann, L. and Rijnbeek, P. and van der Lei, J. and Avillach, P. and Pedersen, L. and Ansell, D. and Pasqua, A. and Mosseveld, M. and Grosdidier, S. and Gungabissoon, U. and Egger, P. and Stewart, R. and Celis-Morales, C. and Alexander, M. and Novak, G. and Gordon, M. F.},\r\n title = {Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe},\r\n journal = {Soc Psychiatry Psychiatr Epidemiol},\r\n volume = {56},\r\n number = {3},\r\n pages = {409-416},\r\n note = {1433-9285 James, Glen Orcid: 0000-0003-0080-3156 Collin, Estelle Lawrance, Marcus Mueller, Achim Podhorna, Jana Zaremba-Pechmann, Liliana Rijnbeek, Peter van der Lei, Johan Avillach, Paul Pedersen, Lars Ansell, David Pasqua, Alessandro Mosseveld, Mees Grosdidier, Solène Gungabissoon, Usha Egger, Peter Stewart, Robert Celis-Morales, Carlos Alexander, Myriam Novak, Gerald Gordon, Mark Forrest MC_PC_17214/MRC_/Medical Research Council/United Kingdom 115372/emif/ Journal Article Germany 2020/06/05 Soc Psychiatry Psychiatr Epidemiol. 2021 Mar;56(3):409-416. doi: 10.1007/s00127-020-01872-2. Epub 2020 Jun 3.},\r\n abstract = {PURPOSE: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer's Disease. METHODS: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. RESULTS: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer's disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-D-aspartate blocker memantine in AUH. CONCLUSION: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer's Disease patients from across Europe.},\r\n keywords = {*Alzheimer Disease/diagnosis/drug therapy\r\n*Electronic Health Records\r\nEurope\r\nGalantamine\r\nHumans\r\nIndans\r\nItaly\r\nNetherlands\r\nPhenylcarbamates\r\nPiperidines\r\nRetrospective Studies\r\nAlzheimer’s disease\r\nDementia\r\nEpidemiology\r\nReal-world data ,\r\nISSN = 0933-7954 ,\r\nDOI = 10.1007/s00127-020-01872-2},\r\n year = {2021},\r\n type = {Journal Article}\r\n}\r\n\r\n","author_short":["James, G.","Collin, E.","Lawrance, M.","Mueller, A.","Podhorna, J.","Zaremba-Pechmann, L.","Rijnbeek, P.","van der Lei, J.","Avillach, P.","Pedersen, L.","Ansell, D.","Pasqua, A.","Mosseveld, M.","Grosdidier, S.","Gungabissoon, U.","Egger, P.","Stewart, R.","Celis-Morales, C.","Alexander, M.","Novak, G.","Gordon, M. 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