Molecular evolution of Dmrt1 accompanies change of sex-determining mechanisms in reptilia. Janes, D E, Organ, C L, Stiglec, R, O'Meally, D, Sarre, S D, Georges, A, Graves, J A, Valenzuela, N, Literman, R A, Rutherford, K, Gemmell, N, Iverson, J B, Tamplin, J W, Edwards, S V, & Ezaz, T Biol Lett, 10(12):20140809-20140809, December, 2014. ![Molecular evolution of Dmrt1 accompanies change of sex-determining mechanisms in reptilia [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex In reptiles, sex-determining mechanisms have evolved repeatedly and reversibly between genotypic and temperature-dependent sex determination. The gene Dmrt1 directs male determination in chicken (and presumably other birds), and regulates sex differentiation in animals as distantly related as fruit flies, nematodes and humans. Here, we show a consistent molecular difference in Dmrt1 between reptiles with genotypic and temperature-dependent sex determination. Among 34 non-avian reptiles, a convergently evolved pair of amino acids encoded by sequence within exon 2 near the DM-binding domain of Dmrt1 distinguishes species with either type of sex determination. We suggest that this amino acid shift accompanied the evolution of genotypic sex determination from an ancestral condition of temperature-dependent sex determination at least three times among reptiles, as evident in turtles, birds and squamates. This novel hypothesis describes the evolution of sex-determining mechanisms as turnover events accompanied by one or two small mutations.
@article{janes2014molecular,
abstract = {In reptiles, sex-determining mechanisms have evolved repeatedly and reversibly between genotypic and temperature-dependent sex determination. The gene Dmrt1 directs male determination in chicken (and presumably other birds), and regulates sex differentiation in animals as distantly related as fruit flies, nematodes and humans. Here, we show a consistent molecular difference in Dmrt1 between reptiles with genotypic and temperature-dependent sex determination. Among 34 non-avian reptiles, a convergently evolved pair of amino acids encoded by sequence within exon 2 near the DM-binding domain of Dmrt1 distinguishes species with either type of sex determination. We suggest that this amino acid shift accompanied the evolution of genotypic sex determination from an ancestral condition of temperature-dependent sex determination at least three times among reptiles, as evident in turtles, birds and squamates. This novel hypothesis describes the evolution of sex-determining mechanisms as turnover events accompanied by one or two small mutations.},
added-at = {2015-06-19T17:31:06.000+0200},
author = {Janes, D E and Organ, C L and Stiglec, R and O'Meally, D and Sarre, S D and Georges, A and Graves, J A and Valenzuela, N and Literman, R A and Rutherford, K and Gemmell, N and Iverson, J B and Tamplin, J W and Edwards, S V and Ezaz, T},
biburl = {https://www.bibsonomy.org/bibtex/2b5dd3a94e3d263f884ffe941858c5e22/peter.ralph},
doi = {10.1098/rsbl.2014.0809},
interhash = {9facb4de1cc7a3812191e992acdcd4c2},
intrahash = {b5dd3a94e3d263f884ffe941858c5e22},
journal = {Biol Lett},
keywords = {Dmrt1 sex_determination convergent_evolution environmental_sex_determination},
month = dec,
number = 12,
pages = {20140809-20140809},
pmid = {25540158},
timestamp = {2015-06-19T17:31:06.000+0200},
title = {Molecular evolution of {Dmrt1} accompanies change of sex-determining mechanisms in reptilia},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25540158},
volume = 10,
year = 2014
}
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Among 34 non-avian reptiles, a convergently evolved pair of amino acids encoded by sequence within exon 2 near the DM-binding domain of Dmrt1 distinguishes species with either type of sex determination. We suggest that this amino acid shift accompanied the evolution of genotypic sex determination from an ancestral condition of temperature-dependent sex determination at least three times among reptiles, as evident in turtles, birds and squamates. 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