@article{jansen_first_2011,
	title = {First study of oral {Artenimol}-{R} in advanced cervical cancer: clinical benefit, tolerability and tumor markers},
	volume = {31},
	issn = {1791-7530},
	shorttitle = {First study of oral {Artenimol}-{R} in advanced cervical cancer},
	abstract = {BACKGROUND/AIM: Artenimol-R is cytotoxic in transformed cervical cells and safety in humans is yet to be established. The present study investigates the clinical benefits, safety and the tumor marker effect of orally administered Artenimol-R in patients with advanced cervix carcinoma.
PATIENTS AND METHODS: Ten patients were treated with Artenimol-R for 28 days. Clinical symptoms, vaginal discharge and pain were followed-up. Adverse events were recorded. Biopsy samples were analyzed by immunohistochemistry for the expression of relevant tumor markers.
RESULTS: Artenimol-R treatment induced clinical remission with a median time for the disappearance of the symptoms being 7 days. No adverse events of grade 3 or 4 occurred. The expression of p53, Epidermal growth factor receptor (EGFR), and antigen Ki-67 as a cellular marker of proliferation, as well as the number of blood vessels stained by the CD31 antibody decreased, whereas the expression of transferrin receptor protein 1 (CD71) increased.
CONCLUSION: The current pilot study provides evidence on the improvement of the clinical symptoms and the good tolerability of Artenimol-R in patients with advanced carcinoma of the cervix uteri. A survival trial with Artenimol-R in advanced patients is warranted.},
	language = {eng},
	number = {12},
	journal = {Anticancer Research},
	author = {Jansen, Frans Herwig and Adoubi, Innocent and J C, Kouassi Comoe and DE Cnodder, Tinne and Jansen, Nicolas and Tschulakow, Alexander and Efferth, Thomas},
	month = dec,
	year = {2011},
	pmid = {22199309},
	keywords = {Administration, Oral, Adult, Aged, Antigens, CD, Antineoplastic Agents, Artemisinins, Biomarkers, Tumor, Carcinoma, ErbB Receptors, Female, Follow-Up Studies, Humans, Immunohistochemistry, Ki-67 Antigen, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1, Receptors, Transferrin, Remission Induction, Treatment Outcome, Uterine Cervical Neoplasms},
	pages = {4417--4422},
}

{"_id":"DRYneR8QHiJx7qjM3","bibbaseid":"jansen-adoubi-jc-decnodder-jansen-tschulakow-efferth-firststudyoforalartenimolrinadvancedcervicalcancerclinicalbenefittolerabilityandtumormarkers-2011","author_short":["Jansen, F. H.","Adoubi, I.","J C, K. C.","DE Cnodder, T.","Jansen, N.","Tschulakow, A.","Efferth, T."],"bibdata":{"bibtype":"article","type":"article","title":"First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers","volume":"31","issn":"1791-7530","shorttitle":"First study of oral Artenimol-R in advanced cervical cancer","abstract":"BACKGROUND/AIM: Artenimol-R is cytotoxic in transformed cervical cells and safety in humans is yet to be established. The present study investigates the clinical benefits, safety and the tumor marker effect of orally administered Artenimol-R in patients with advanced cervix carcinoma. PATIENTS AND METHODS: Ten patients were treated with Artenimol-R for 28 days. Clinical symptoms, vaginal discharge and pain were followed-up. Adverse events were recorded. Biopsy samples were analyzed by immunohistochemistry for the expression of relevant tumor markers. RESULTS: Artenimol-R treatment induced clinical remission with a median time for the disappearance of the symptoms being 7 days. No adverse events of grade 3 or 4 occurred. The expression of p53, Epidermal growth factor receptor (EGFR), and antigen Ki-67 as a cellular marker of proliferation, as well as the number of blood vessels stained by the CD31 antibody decreased, whereas the expression of transferrin receptor protein 1 (CD71) increased. CONCLUSION: The current pilot study provides evidence on the improvement of the clinical symptoms and the good tolerability of Artenimol-R in patients with advanced carcinoma of the cervix uteri. A survival trial with Artenimol-R in advanced patients is warranted.","language":"eng","number":"12","journal":"Anticancer Research","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["Frans","Herwig"],"suffixes":[]},{"propositions":[],"lastnames":["Adoubi"],"firstnames":["Innocent"],"suffixes":[]},{"propositions":[],"lastnames":["J","C"],"firstnames":["Kouassi","Comoe"],"suffixes":[]},{"propositions":[],"lastnames":["DE","Cnodder"],"firstnames":["Tinne"],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["Nicolas"],"suffixes":[]},{"propositions":[],"lastnames":["Tschulakow"],"firstnames":["Alexander"],"suffixes":[]},{"propositions":[],"lastnames":["Efferth"],"firstnames":["Thomas"],"suffixes":[]}],"month":"December","year":"2011","pmid":"22199309","keywords":"Administration, Oral, Adult, Aged, Antigens, CD, Antineoplastic Agents, Artemisinins, Biomarkers, Tumor, Carcinoma, ErbB Receptors, Female, Follow-Up Studies, Humans, Immunohistochemistry, Ki-67 Antigen, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1, Receptors, Transferrin, Remission Induction, Treatment Outcome, Uterine Cervical Neoplasms","pages":"4417–4422","bibtex":"@article{jansen_first_2011,\n\ttitle = {First study of oral {Artenimol}-{R} in advanced cervical cancer: clinical benefit, tolerability and tumor markers},\n\tvolume = {31},\n\tissn = {1791-7530},\n\tshorttitle = {First study of oral {Artenimol}-{R} in advanced cervical cancer},\n\tabstract = {BACKGROUND/AIM: Artenimol-R is cytotoxic in transformed cervical cells and safety in humans is yet to be established. The present study investigates the clinical benefits, safety and the tumor marker effect of orally administered Artenimol-R in patients with advanced cervix carcinoma.\nPATIENTS AND METHODS: Ten patients were treated with Artenimol-R for 28 days. Clinical symptoms, vaginal discharge and pain were followed-up. Adverse events were recorded. Biopsy samples were analyzed by immunohistochemistry for the expression of relevant tumor markers.\nRESULTS: Artenimol-R treatment induced clinical remission with a median time for the disappearance of the symptoms being 7 days. No adverse events of grade 3 or 4 occurred. The expression of p53, Epidermal growth factor receptor (EGFR), and antigen Ki-67 as a cellular marker of proliferation, as well as the number of blood vessels stained by the CD31 antibody decreased, whereas the expression of transferrin receptor protein 1 (CD71) increased.\nCONCLUSION: The current pilot study provides evidence on the improvement of the clinical symptoms and the good tolerability of Artenimol-R in patients with advanced carcinoma of the cervix uteri. A survival trial with Artenimol-R in advanced patients is warranted.},\n\tlanguage = {eng},\n\tnumber = {12},\n\tjournal = {Anticancer Research},\n\tauthor = {Jansen, Frans Herwig and Adoubi, Innocent and J C, Kouassi Comoe and DE Cnodder, Tinne and Jansen, Nicolas and Tschulakow, Alexander and Efferth, Thomas},\n\tmonth = dec,\n\tyear = {2011},\n\tpmid = {22199309},\n\tkeywords = {Administration, Oral, Adult, Aged, Antigens, CD, Antineoplastic Agents, Artemisinins, Biomarkers, Tumor, Carcinoma, ErbB Receptors, Female, Follow-Up Studies, Humans, Immunohistochemistry, Ki-67 Antigen, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1, Receptors, Transferrin, Remission Induction, Treatment Outcome, Uterine Cervical Neoplasms},\n\tpages = {4417--4422},\n}\n\n","author_short":["Jansen, F. H.","Adoubi, I.","J C, K. 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