Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy. Jansen, J. F., Aldenkamp, A. P., Marian Majoie, H. J., Reijs, R. P., de Krom, M. C., Hofman, P. A., Eline Kooi, M., Nicolay, K., & Backes, W. H. Epilepsy Behav, 9(1):181-5, 2006. Jansen, Jacobus F A Aldenkamp, Albert P Marian Majoie, H J Reijs, Rianne P de Krom, Marc C T F M Hofman, Paul A M Eline Kooi, M Nicolay, Klaas Backes, Walter H eng 2006/06/24 09:00 Epilepsy Behav. 2006 Aug;9(1):181-5. doi: 10.1016/j.yebeh.2006.05.004. Epub 2006 Jun 21.
Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy [link]Paper  doi  abstract   bibtex   
Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.

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