1H MR spectroscopy of the brain: absolute quantification of metabolites

1H MR spectroscopy of the brain: absolute quantification of metabolites. Jansen, J. F., Backes, W. H., Nicolay, K., & Kooi, M. E. Radiology, 240(2):318-32, 2006. Jansen, Jacobus F A Backes, Walter H Nicolay, Klaas Kooi, M Eline eng Review 2006/07/26 09:00 Radiology. 2006 Aug;240(2):318-32. doi: 10.1148/radiol.2402050314.

Paper doi abstract bibtex

Hydrogen 1 (1H) magnetic resonance (MR) spectroscopy enables noninvasive in vivo quantification of metabolite concentrations in the brain. Currently, metabolite concentrations are most often presented as ratios (eg, relative to creatine) rather than as absolute concentrations. Despite the success of this approach, it has recently been suggested that relative quantification may introduce substantial errors and can lead to misinterpretation of spectral data and to erroneous metabolite values. The present review discusses relevant methods to obtain absolute metabolite concentrations with a clinical MR system by using single-voxel spectroscopy or chemical shift imaging. Important methodological aspects in an absolute quantification strategy are addressed, including radiofrequency coil properties, calibration procedures, spectral fitting methods, cerebrospinal fluid content correction, macromolecule suppression, and spectral editing. Techniques to obtain absolute concentrations are now available and can be successfully applied in clinical practice. Although the present review is focused on 1H MR spectroscopy of the brain, a large part of the methodology described can be applied to other tissues as well.

@article{RN125,
   author = {Jansen, J. F. and Backes, W. H. and Nicolay, K. and Kooi, M. E.},
   title = {1H MR spectroscopy of the brain: absolute quantification of metabolites},
   journal = {Radiology},
   volume = {240},
   number = {2},
   pages = {318-32},
   note = {Jansen, Jacobus F A
Backes, Walter H
Nicolay, Klaas
Kooi, M Eline
eng
Review
2006/07/26 09:00
Radiology. 2006 Aug;240(2):318-32. doi: 10.1148/radiol.2402050314.},
   abstract = {Hydrogen 1 (1H) magnetic resonance (MR) spectroscopy enables noninvasive in vivo quantification of metabolite concentrations in the brain. Currently, metabolite concentrations are most often presented as ratios (eg, relative to creatine) rather than as absolute concentrations. Despite the success of this approach, it has recently been suggested that relative quantification may introduce substantial errors and can lead to misinterpretation of spectral data and to erroneous metabolite values. The present review discusses relevant methods to obtain absolute metabolite concentrations with a clinical MR system by using single-voxel spectroscopy or chemical shift imaging. Important methodological aspects in an absolute quantification strategy are addressed, including radiofrequency coil properties, calibration procedures, spectral fitting methods, cerebrospinal fluid content correction, macromolecule suppression, and spectral editing. Techniques to obtain absolute concentrations are now available and can be successfully applied in clinical practice. Although the present review is focused on 1H MR spectroscopy of the brain, a large part of the methodology described can be applied to other tissues as well.},
   keywords = {Brain/*metabolism
*Brain Chemistry
Calibration
Humans
Magnetic Resonance Spectroscopy/instrumentation/*methods
Signal Processing, Computer-Assisted
Statistics as Topic},
   ISSN = {0033-8419 (Print)
0033-8419 (Linking)},
   DOI = {10.1148/radiol.2402050314},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/16864664},
   year = {2006},
   type = {Journal Article}
}

Downloads: 0

{"_id":"hunvkS2StamdS5gDa","bibbaseid":"jansen-backes-nicolay-kooi-1hmrspectroscopyofthebrainabsolutequantificationofmetabolites-2006","downloads":0,"creationDate":"2017-09-02T18:10:13.584Z","title":"1H MR spectroscopy of the brain: absolute quantification of metabolites","author_short":["Jansen, J. F.","Backes, W. H.","Nicolay, K.","Kooi, M. E."],"year":2006,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Nicolay"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Kooi"],"firstnames":["M.","E."],"suffixes":[]}],"title":"1H MR spectroscopy of the brain: absolute quantification of metabolites","journal":"Radiology","volume":"240","number":"2","pages":"318-32","note":"Jansen, Jacobus F A Backes, Walter H Nicolay, Klaas Kooi, M Eline eng Review 2006/07/26 09:00 Radiology. 2006 Aug;240(2):318-32. doi: 10.1148/radiol.2402050314.","abstract":"Hydrogen 1 (1H) magnetic resonance (MR) spectroscopy enables noninvasive in vivo quantification of metabolite concentrations in the brain. Currently, metabolite concentrations are most often presented as ratios (eg, relative to creatine) rather than as absolute concentrations. Despite the success of this approach, it has recently been suggested that relative quantification may introduce substantial errors and can lead to misinterpretation of spectral data and to erroneous metabolite values. The present review discusses relevant methods to obtain absolute metabolite concentrations with a clinical MR system by using single-voxel spectroscopy or chemical shift imaging. Important methodological aspects in an absolute quantification strategy are addressed, including radiofrequency coil properties, calibration procedures, spectral fitting methods, cerebrospinal fluid content correction, macromolecule suppression, and spectral editing. Techniques to obtain absolute concentrations are now available and can be successfully applied in clinical practice. Although the present review is focused on 1H MR spectroscopy of the brain, a large part of the methodology described can be applied to other tissues as well.","keywords":"Brain/*metabolism *Brain Chemistry Calibration Humans Magnetic Resonance Spectroscopy/instrumentation/*methods Signal Processing, Computer-Assisted Statistics as Topic","issn":"0033-8419 (Print) 0033-8419 (Linking)","doi":"10.1148/radiol.2402050314","url":"http://www.ncbi.nlm.nih.gov/pubmed/16864664","year":"2006","bibtex":"@article{RN125,\n author = {Jansen, J. F. and Backes, W. H. and Nicolay, K. and Kooi, M. E.},\n title = {1H MR spectroscopy of the brain: absolute quantification of metabolites},\n journal = {Radiology},\n volume = {240},\n number = {2},\n pages = {318-32},\n note = {Jansen, Jacobus F A\nBackes, Walter H\nNicolay, Klaas\nKooi, M Eline\neng\nReview\n2006/07/26 09:00\nRadiology. 2006 Aug;240(2):318-32. doi: 10.1148/radiol.2402050314.},\n abstract = {Hydrogen 1 (1H) magnetic resonance (MR) spectroscopy enables noninvasive in vivo quantification of metabolite concentrations in the brain. Currently, metabolite concentrations are most often presented as ratios (eg, relative to creatine) rather than as absolute concentrations. Despite the success of this approach, it has recently been suggested that relative quantification may introduce substantial errors and can lead to misinterpretation of spectral data and to erroneous metabolite values. The present review discusses relevant methods to obtain absolute metabolite concentrations with a clinical MR system by using single-voxel spectroscopy or chemical shift imaging. Important methodological aspects in an absolute quantification strategy are addressed, including radiofrequency coil properties, calibration procedures, spectral fitting methods, cerebrospinal fluid content correction, macromolecule suppression, and spectral editing. Techniques to obtain absolute concentrations are now available and can be successfully applied in clinical practice. Although the present review is focused on 1H MR spectroscopy of the brain, a large part of the methodology described can be applied to other tissues as well.},\n keywords = {Brain/*metabolism\n*Brain Chemistry\nCalibration\nHumans\nMagnetic Resonance Spectroscopy/instrumentation/*methods\nSignal Processing, Computer-Assisted\nStatistics as Topic},\n ISSN = {0033-8419 (Print)\n0033-8419 (Linking)},\n DOI = {10.1148/radiol.2402050314},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/16864664},\n year = {2006},\n type = {Journal Article}\n}\n\n","author_short":["Jansen, J. F.","Backes, W. H.","Nicolay, K.","Kooi, M. E."],"key":"RN125","id":"RN125","bibbaseid":"jansen-backes-nicolay-kooi-1hmrspectroscopyofthebrainabsolutequantificationofmetabolites-2006","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/16864664"},"keyword":["Brain/*metabolism *Brain Chemistry Calibration Humans Magnetic Resonance Spectroscopy/instrumentation/*methods Signal Processing","Computer-Assisted Statistics as Topic"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["spectroscopy","brain","absolute","quantification","metabolites","jansen","backes","nicolay","kooi"],"keywords":["brain/*metabolism *brain chemistry calibration humans magnetic resonance spectroscopy/instrumentation/*methods signal processing","computer-assisted statistics as topic"],"authorIDs":["59aae01e5ead235c6f00001d","5df1707557cfb4de0100001d","5e024e386ffa15df0100007a","5e47cbe8af70c7de0100001a","5e4ea88f64b624de01000110","5e685fc7149172de01000144","9uYiZAT4SGYEdwuhG","CHX5tw5dNmS7tFMt9","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","H6wbK4u5jYRFL8LDs","Jeci2sNzJiMSDeJvc","QqoDaykDZWJd9YuAu","RLbGKAvkbQAw2q2pz","TCejZCDssndxpTcJg","TEAWLnKpXtQE8hs6C","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","gxe8DkJ5qKbznZgZq","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","rQrciQZhPyL9ovwM8","ryLRyF5HAWnpncbbr","sFGhcvCCManvCwLHz","zTR82AHQxLXLWt4wi"],"dataSources":["TCkfRWJAZvbLAZi29"]}