@article{RN150,
   author = {Jansen, J. F. and Carlson, D. L. and Lu, Y. and Stambuk, H. E. and Moreira, A. L. and Singh, B. and Patel, S. G. and Kraus, D. H. and Wong, R. J. and Shaha, A. R. and Shah, J. P. and Shukla-Dave, A.},
   title = {Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis},
   journal = {Oral Oncol},
   volume = {48},
   number = {8},
   pages = {717-22},
   note = {Jansen, Jacobus F A
Carlson, Diane L
Lu, Yonggang
Stambuk, Hilda E
Moreira, Andre L
Singh, Bhuvanesh
Patel, Snehal G
Kraus, Dennis H
Wong, Richard J
Shaha, Ashok R
Shah, Jatin P
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-05/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
England
2012/03/01 06:00
Oral Oncol. 2012 Aug;48(8):717-22. doi: 10.1016/j.oraloncology.2012.02.001. Epub 2012 Feb 25.},
   abstract = {The aim of the present study is to correlate non-invasive, pretreatment biological imaging (dynamic contrast enhanced-MRI [DCE-MRI] and proton magnetic resonance spectroscopy [(1)H-MRS]) findings with specific molecular marker data in neck nodal metastases of head and neck squamous cell carcinoma (HNSCC) patients. Pretreatment DCE-MRI and (1)H-MRS were performed on neck nodal metastases of 12 patients who underwent surgery. Surgical specimens were analyzed with immunohistochemistry (IHC) assays for: Ki-67 (reflecting cellular proliferation), vascular endothelial growth factor (VEGF) (the "endogenous marker" of tumor vessel growth), carbonic anhydrase (CAIX), hypoxia inducible transcription factor (HIF-1alpha), and human papillomavirus (HPV). Additionally, necrosis was estimated based on H&E staining. The Spearman correlation was used to compare DCE-MRI, (1)H-MRS, and molecular marker data. A significant correlation was observed between DCE-MRI parameter std(k(ep)) and VEGF IHC expression level (rho=0.81, p=0.0001). Furthermore, IHC expression levels of Ki-67 inversely correlated with std(K(trans)) and std(v(e)) (rho=-0.71; p=0.004, and rho=-0.73; p=0.003, respectively). Other DCE-MRI, (1)H-MRS and IHC values did not show significant correlation. The results of this preliminary study indicate that the level of heterogeneity of perfusion in metastatic HNSCC seems positively correlated with angiogenesis, and inversely correlated with proliferation. These results are preliminary in nature and are indicative, and not definitive, trends portrayed in HNSCC patients with nodal disease. Future studies with larger patient populations need to be carried out to validate and clarify our preliminary findings.},
   keywords = {Adult
Aged
Biomarkers, Tumor/metabolism
Carbonic Anhydrases/metabolism
Carcinoma, Squamous Cell/*diagnosis/metabolism/secondary
Contrast Media
Female
Human papillomavirus 16/metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Ki-67 Antigen/metabolism
Lymph Nodes/*pathology
Lymphatic Metastasis
Magnetic Resonance Imaging/*methods
Magnetic Resonance Spectroscopy/*methods
Male
Middle Aged
Mouth Neoplasms/*diagnosis/metabolism/pathology
Neck
Vascular Endothelial Growth Factor A/metabolism},
   ISSN = {1879-0593 (Electronic)
1368-8375 (Linking)},
   DOI = {10.1016/j.oraloncology.2012.02.001},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22366441
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368067/pdf/nihms355666.pdf},
   year = {2012},
   type = {Journal Article}
}

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P.","Shukla-Dave, A."],"year":2012,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Carlson"],"firstnames":["D.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Lu"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Stambuk"],"firstnames":["H.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Moreira"],"firstnames":["A.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Singh"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["S.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Kraus"],"firstnames":["D.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Wong"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Shaha"],"firstnames":["A.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Shah"],"firstnames":["J.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Shukla-Dave"],"firstnames":["A."],"suffixes":[]}],"title":"Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis","journal":"Oral Oncol","volume":"48","number":"8","pages":"717-22","note":"Jansen, Jacobus F A Carlson, Diane L Lu, Yonggang Stambuk, Hilda E Moreira, Andre L Singh, Bhuvanesh Patel, Snehal G Kraus, Dennis H Wong, Richard J Shaha, Ashok R Shah, Jatin P Shukla-Dave, Amita eng R01 CA115895/CA/NCI NIH HHS/ R01 CA115895-05/CA/NCI NIH HHS/ 1 R01 CA115895/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural England 2012/03/01 06:00 Oral Oncol. 2012 Aug;48(8):717-22. doi: 10.1016/j.oraloncology.2012.02.001. Epub 2012 Feb 25.","abstract":"The aim of the present study is to correlate non-invasive, pretreatment biological imaging (dynamic contrast enhanced-MRI [DCE-MRI] and proton magnetic resonance spectroscopy [(1)H-MRS]) findings with specific molecular marker data in neck nodal metastases of head and neck squamous cell carcinoma (HNSCC) patients. Pretreatment DCE-MRI and (1)H-MRS were performed on neck nodal metastases of 12 patients who underwent surgery. Surgical specimens were analyzed with immunohistochemistry (IHC) assays for: Ki-67 (reflecting cellular proliferation), vascular endothelial growth factor (VEGF) (the \"endogenous marker\" of tumor vessel growth), carbonic anhydrase (CAIX), hypoxia inducible transcription factor (HIF-1alpha), and human papillomavirus (HPV). Additionally, necrosis was estimated based on H&E staining. The Spearman correlation was used to compare DCE-MRI, (1)H-MRS, and molecular marker data. A significant correlation was observed between DCE-MRI parameter std(k(ep)) and VEGF IHC expression level (rho=0.81, p=0.0001). Furthermore, IHC expression levels of Ki-67 inversely correlated with std(K(trans)) and std(v(e)) (rho=-0.71; p=0.004, and rho=-0.73; p=0.003, respectively). Other DCE-MRI, (1)H-MRS and IHC values did not show significant correlation. The results of this preliminary study indicate that the level of heterogeneity of perfusion in metastatic HNSCC seems positively correlated with angiogenesis, and inversely correlated with proliferation. These results are preliminary in nature and are indicative, and not definitive, trends portrayed in HNSCC patients with nodal disease. Future studies with larger patient populations need to be carried out to validate and clarify our preliminary findings.","keywords":"Adult Aged Biomarkers, Tumor/metabolism Carbonic Anhydrases/metabolism Carcinoma, Squamous Cell/*diagnosis/metabolism/secondary Contrast Media Female Human papillomavirus 16/metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit/metabolism Ki-67 Antigen/metabolism Lymph Nodes/*pathology Lymphatic Metastasis Magnetic Resonance Imaging/*methods Magnetic Resonance Spectroscopy/*methods Male Middle Aged Mouth Neoplasms/*diagnosis/metabolism/pathology Neck Vascular Endothelial Growth Factor A/metabolism","issn":"1879-0593 (Electronic) 1368-8375 (Linking)","doi":"10.1016/j.oraloncology.2012.02.001","url":"http://www.ncbi.nlm.nih.gov/pubmed/22366441 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368067/pdf/nihms355666.pdf","year":"2012","bibtex":"@article{RN150,\n author = {Jansen, J. F. and Carlson, D. L. and Lu, Y. and Stambuk, H. E. and Moreira, A. L. and Singh, B. and Patel, S. G. and Kraus, D. H. and Wong, R. J. and Shaha, A. R. and Shah, J. P. and Shukla-Dave, A.},\n title = {Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis},\n journal = {Oral Oncol},\n volume = {48},\n number = {8},\n pages = {717-22},\n note = {Jansen, Jacobus F A\nCarlson, Diane L\nLu, Yonggang\nStambuk, Hilda E\nMoreira, Andre L\nSingh, Bhuvanesh\nPatel, Snehal G\nKraus, Dennis H\nWong, Richard J\nShaha, Ashok R\nShah, Jatin P\nShukla-Dave, Amita\neng\nR01 CA115895/CA/NCI NIH HHS/\nR01 CA115895-05/CA/NCI NIH HHS/\n1 R01 CA115895/CA/NCI NIH HHS/\nResearch Support, N.I.H., Extramural\nEngland\n2012/03/01 06:00\nOral Oncol. 2012 Aug;48(8):717-22. doi: 10.1016/j.oraloncology.2012.02.001. Epub 2012 Feb 25.},\n abstract = {The aim of the present study is to correlate non-invasive, pretreatment biological imaging (dynamic contrast enhanced-MRI [DCE-MRI] and proton magnetic resonance spectroscopy [(1)H-MRS]) findings with specific molecular marker data in neck nodal metastases of head and neck squamous cell carcinoma (HNSCC) patients. Pretreatment DCE-MRI and (1)H-MRS were performed on neck nodal metastases of 12 patients who underwent surgery. Surgical specimens were analyzed with immunohistochemistry (IHC) assays for: Ki-67 (reflecting cellular proliferation), vascular endothelial growth factor (VEGF) (the \"endogenous marker\" of tumor vessel growth), carbonic anhydrase (CAIX), hypoxia inducible transcription factor (HIF-1alpha), and human papillomavirus (HPV). Additionally, necrosis was estimated based on H&E staining. The Spearman correlation was used to compare DCE-MRI, (1)H-MRS, and molecular marker data. A significant correlation was observed between DCE-MRI parameter std(k(ep)) and VEGF IHC expression level (rho=0.81, p=0.0001). Furthermore, IHC expression levels of Ki-67 inversely correlated with std(K(trans)) and std(v(e)) (rho=-0.71; p=0.004, and rho=-0.73; p=0.003, respectively). Other DCE-MRI, (1)H-MRS and IHC values did not show significant correlation. The results of this preliminary study indicate that the level of heterogeneity of perfusion in metastatic HNSCC seems positively correlated with angiogenesis, and inversely correlated with proliferation. These results are preliminary in nature and are indicative, and not definitive, trends portrayed in HNSCC patients with nodal disease. Future studies with larger patient populations need to be carried out to validate and clarify our preliminary findings.},\n keywords = {Adult\nAged\nBiomarkers, Tumor/metabolism\nCarbonic Anhydrases/metabolism\nCarcinoma, Squamous Cell/*diagnosis/metabolism/secondary\nContrast Media\nFemale\nHuman papillomavirus 16/metabolism\nHumans\nHypoxia-Inducible Factor 1, alpha Subunit/metabolism\nKi-67 Antigen/metabolism\nLymph Nodes/*pathology\nLymphatic Metastasis\nMagnetic Resonance Imaging/*methods\nMagnetic Resonance Spectroscopy/*methods\nMale\nMiddle Aged\nMouth Neoplasms/*diagnosis/metabolism/pathology\nNeck\nVascular Endothelial Growth Factor A/metabolism},\n ISSN = {1879-0593 (Electronic)\n1368-8375 (Linking)},\n DOI = {10.1016/j.oraloncology.2012.02.001},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/22366441\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368067/pdf/nihms355666.pdf},\n year = {2012},\n type = {Journal Article}\n}\n\n","author_short":["Jansen, J. F.","Carlson, D. 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