Short- and long-term limbic abnormalities after experimental febrile seizures. Jansen, J. F., Lemmens, E. M., Strijkers, G. J., Prompers, J. J., Schijns, O. E., Kooi, M. E., Beuls, E. A., Nicolay, K., Backes, W. H., & Hoogland, G. Neurobiol Dis, 32(2):293-301, 2008. Jansen, Jacobus F A Lemmens, Evi M P Strijkers, Gustav J Prompers, Jeanine J Schijns, Olaf E M G Kooi, M Eline Beuls, Emile A M Nicolay, Klaas Backes, Walter H Hoogland, Govert eng 2008/08/19 09:00 Neurobiol Dis. 2008 Nov;32(2):293-301. doi: 10.1016/j.nbd.2008.07.010. Epub 2008 Jul 27.![Short- and long-term limbic abnormalities after experimental febrile seizures [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations.
@article{RN131,
author = {Jansen, J. F. and Lemmens, E. M. and Strijkers, G. J. and Prompers, J. J. and Schijns, O. E. and Kooi, M. E. and Beuls, E. A. and Nicolay, K. and Backes, W. H. and Hoogland, G.},
title = {Short- and long-term limbic abnormalities after experimental febrile seizures},
journal = {Neurobiol Dis},
volume = {32},
number = {2},
pages = {293-301},
note = {Jansen, Jacobus F A
Lemmens, Evi M P
Strijkers, Gustav J
Prompers, Jeanine J
Schijns, Olaf E M G
Kooi, M Eline
Beuls, Emile A M
Nicolay, Klaas
Backes, Walter H
Hoogland, Govert
eng
2008/08/19 09:00
Neurobiol Dis. 2008 Nov;32(2):293-301. doi: 10.1016/j.nbd.2008.07.010. Epub 2008 Jul 27.},
abstract = {Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations.},
keywords = {Animals
Diffusion Magnetic Resonance Imaging/methods
Disease Models, Animal
Follow-Up Studies
Hippocampus/*pathology/*physiopathology
Hyperthermia, Induced/adverse effects
Image Processing, Computer-Assisted
Magnetic Resonance Imaging/methods
Magnetic Resonance Spectroscopy
Neural Pathways/pathology
Protons
Rats
Rats, Sprague-Dawley
Seizures, Febrile/etiology/metabolism/*pathology
Time Factors},
ISSN = {1095-953X (Electronic)
0969-9961 (Linking)},
DOI = {10.1016/j.nbd.2008.07.010},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18707002
https://www.sciencedirect.com/science/article/abs/pii/S0969996108001666?via%3Dihub},
year = {2008},
type = {Journal Article}
}
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H. and Hoogland, G.},\n title = {Short- and long-term limbic abnormalities after experimental febrile seizures},\n journal = {Neurobiol Dis},\n volume = {32},\n number = {2},\n pages = {293-301},\n note = {Jansen, Jacobus F A\nLemmens, Evi M P\nStrijkers, Gustav J\nPrompers, Jeanine J\nSchijns, Olaf E M G\nKooi, M Eline\nBeuls, Emile A M\nNicolay, Klaas\nBackes, Walter H\nHoogland, Govert\neng\n2008/08/19 09:00\nNeurobiol Dis. 2008 Nov;32(2):293-301. doi: 10.1016/j.nbd.2008.07.010. Epub 2008 Jul 27.},\n abstract = {Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. 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