@article{RN151,
   author = {Jansen, J. F. and Schoder, H. and Lee, N. Y. and Stambuk, H. E. and Wang, Y. and Fury, M. G. and Patel, S. G. and Pfister, D. G. and Shah, J. P. and Koutcher, J. A. and Shukla-Dave, A.},
   title = {Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET},
   journal = {Int J Radiat Oncol Biol Phys},
   volume = {82},
   number = {1},
   pages = {299-307},
   note = {Jansen, Jacobus F A
Schoder, Heiko
Lee, Nancy Y
Stambuk, Hilda E
Wang, Ya
Fury, Matthew G
Patel, Snehal G
Pfister, David G
Shah, Jatin P
Koutcher, Jason A
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-05/CA/NCI NIH HHS/
1R01CA-115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
2011/01/18 06:00
Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):299-307. doi: 10.1016/j.ijrobp.2010.11.022. Epub 2011 Jan 13.},
   abstract = {PURPOSE: To correlate proton magnetic resonance spectroscopy ((1)H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and (18)F-labeled fluorodeoxyglucose positron emission tomography ([(18)F]FDG PET) of nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging was evaluated for its efficacy in predicting short-term response to treatment. METHODS AND MATERIALS: Metastatic neck nodes were imaged with (1)H-MRS, DCE-MRI, and [(18)F]FDG PET in 16 patients with newly diagnosed HNSCC, before treatment. Short-term patient radiological response was evaluated at 3 to 4 months. Correlations among (1)H-MRS (choline concentration relative to water [Cho/W]), DCE-MRI (volume transfer constant [K(trans)]; volume fraction of the extravascular extracellular space [v(e)]; and redistribution rate constant [k(ep)]), and [(18)F]FDG PET (standard uptake value [SUV] and total lesion glycolysis [TLG]) were calculated using nonparametric Spearman rank correlation. To predict short-term responses, logistic regression analysis was performed. RESULTS: A significant positive correlation was found between Cho/W and TLG (rho = 0.599; p = 0.031). Cho/W correlated negatively with heterogeneity measures of standard deviation std(v(e)) (rho = -0.691; p = 0.004) and std(k(ep)) (rho = -0.704; p = 0.003). Maximum SUV (SUVmax) values correlated strongly with MRI tumor volume (rho = 0.643; p = 0.007). Logistic regression indicated that std(K(trans)) and SUVmean were significant predictors of short-term response (p < 0.07). CONCLUSION: Pretreatment multimodality imaging using (1)H-MRS, DCE-MRI, and [(18)F]FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and [(18)F]FDG PET parameters were predictive of short-term response to treatment.},
   keywords = {Adult
Aged
Antibodies, Monoclonal, Humanized/therapeutic use
Antineoplastic Agents/therapeutic use
Bevacizumab
Carcinoma, Squamous Cell/*metabolism/secondary/therapy
Chemoradiotherapy/methods
Choline/metabolism
Cisplatin/therapeutic use
Contrast Media
Diagnostic Imaging/*methods
Extracellular Space/metabolism
Feasibility Studies
Female
Fluorodeoxyglucose F18/pharmacokinetics
Fluorouracil/therapeutic use
Gadolinium DTPA
Glucose/metabolism
Glycolysis
Head and Neck Neoplasms/*metabolism/pathology/therapy
Humans
Lymphatic Metastasis
Magnetic Resonance Imaging/methods
Magnetic Resonance Spectroscopy/methods
Male
Middle Aged
Nasopharyngeal Neoplasms/metabolism/pathology/therapy
Positron-Emission Tomography/methods
Prospective Studies
Radiopharmaceuticals/pharmacokinetics
Regression Analysis
Statistics, Nonparametric
Tongue Neoplasms/metabolism/pathology/therapy
Tonsillar Neoplasms/metabolism/pathology/therapy},
   ISSN = {1879-355X (Electronic)
0360-3016 (Linking)},
   DOI = {10.1016/j.ijrobp.2010.11.022},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/21236594
https://www.redjournal.org/article/S0360-3016(10)03570-4/pdf},
   year = {2012},
   type = {Journal Article}
}

{"_id":"cwQaQC5uNFnKBECN7","bibbaseid":"jansen-schoder-lee-stambuk-wang-fury-patel-pfister-etal-tumormetabolismandperfusioninheadandnecksquamouscellcarcinomapretreatmentmultimodalityimagingwith1hmagneticresonancespectroscopydynamiccontrastenhancedmriand18ffdgpet-2012","authorIDs":["TEAWLnKpXtQE8hs6C"],"author_short":["Jansen, J. F.","Schoder, H.","Lee, N. Y.","Stambuk, H. E.","Wang, Y.","Fury, M. G.","Patel, S. G.","Pfister, D. G.","Shah, J. P.","Koutcher, J. A.","Shukla-Dave, A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Schoder"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["N.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Stambuk"],"firstnames":["H.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Fury"],"firstnames":["M.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["S.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Pfister"],"firstnames":["D.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Shah"],"firstnames":["J.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Koutcher"],"firstnames":["J.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Shukla-Dave"],"firstnames":["A."],"suffixes":[]}],"title":"Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET","journal":"Int J Radiat Oncol Biol Phys","volume":"82","number":"1","pages":"299-307","note":"Jansen, Jacobus F A Schoder, Heiko Lee, Nancy Y Stambuk, Hilda E Wang, Ya Fury, Matthew G Patel, Snehal G Pfister, David G Shah, Jatin P Koutcher, Jason A Shukla-Dave, Amita eng R01 CA115895/CA/NCI NIH HHS/ R01 CA115895-05/CA/NCI NIH HHS/ 1R01CA-115895/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural 2011/01/18 06:00 Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):299-307. doi: 10.1016/j.ijrobp.2010.11.022. Epub 2011 Jan 13.","abstract":"PURPOSE: To correlate proton magnetic resonance spectroscopy ((1)H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and (18)F-labeled fluorodeoxyglucose positron emission tomography ([(18)F]FDG PET) of nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging was evaluated for its efficacy in predicting short-term response to treatment. METHODS AND MATERIALS: Metastatic neck nodes were imaged with (1)H-MRS, DCE-MRI, and [(18)F]FDG PET in 16 patients with newly diagnosed HNSCC, before treatment. Short-term patient radiological response was evaluated at 3 to 4 months. Correlations among (1)H-MRS (choline concentration relative to water [Cho/W]), DCE-MRI (volume transfer constant [K(trans)]; volume fraction of the extravascular extracellular space [v(e)]; and redistribution rate constant [k(ep)]), and [(18)F]FDG PET (standard uptake value [SUV] and total lesion glycolysis [TLG]) were calculated using nonparametric Spearman rank correlation. To predict short-term responses, logistic regression analysis was performed. RESULTS: A significant positive correlation was found between Cho/W and TLG (rho = 0.599; p = 0.031). Cho/W correlated negatively with heterogeneity measures of standard deviation std(v(e)) (rho = -0.691; p = 0.004) and std(k(ep)) (rho = -0.704; p = 0.003). Maximum SUV (SUVmax) values correlated strongly with MRI tumor volume (rho = 0.643; p = 0.007). Logistic regression indicated that std(K(trans)) and SUVmean were significant predictors of short-term response (p < 0.07). CONCLUSION: Pretreatment multimodality imaging using (1)H-MRS, DCE-MRI, and [(18)F]FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and [(18)F]FDG PET parameters were predictive of short-term response to treatment.","keywords":"Adult Aged Antibodies, Monoclonal, Humanized/therapeutic use Antineoplastic Agents/therapeutic use Bevacizumab Carcinoma, Squamous Cell/*metabolism/secondary/therapy Chemoradiotherapy/methods Choline/metabolism Cisplatin/therapeutic use Contrast Media Diagnostic Imaging/*methods Extracellular Space/metabolism Feasibility Studies Female Fluorodeoxyglucose F18/pharmacokinetics Fluorouracil/therapeutic use Gadolinium DTPA Glucose/metabolism Glycolysis Head and Neck Neoplasms/*metabolism/pathology/therapy Humans Lymphatic Metastasis Magnetic Resonance Imaging/methods Magnetic Resonance Spectroscopy/methods Male Middle Aged Nasopharyngeal Neoplasms/metabolism/pathology/therapy Positron-Emission Tomography/methods Prospective Studies Radiopharmaceuticals/pharmacokinetics Regression Analysis Statistics, Nonparametric Tongue Neoplasms/metabolism/pathology/therapy Tonsillar Neoplasms/metabolism/pathology/therapy","issn":"1879-355X (Electronic) 0360-3016 (Linking)","doi":"10.1016/j.ijrobp.2010.11.022","url":"http://www.ncbi.nlm.nih.gov/pubmed/21236594 https://www.redjournal.org/article/S0360-3016(10)03570-4/pdf","year":"2012","bibtex":"@article{RN151,\n author = {Jansen, J. F. and Schoder, H. and Lee, N. Y. and Stambuk, H. E. and Wang, Y. and Fury, M. G. and Patel, S. G. and Pfister, D. G. and Shah, J. P. and Koutcher, J. A. and Shukla-Dave, A.},\n title = {Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET},\n journal = {Int J Radiat Oncol Biol Phys},\n volume = {82},\n number = {1},\n pages = {299-307},\n note = {Jansen, Jacobus F A\nSchoder, Heiko\nLee, Nancy Y\nStambuk, Hilda E\nWang, Ya\nFury, Matthew G\nPatel, Snehal G\nPfister, David G\nShah, Jatin P\nKoutcher, Jason A\nShukla-Dave, Amita\neng\nR01 CA115895/CA/NCI NIH HHS/\nR01 CA115895-05/CA/NCI NIH HHS/\n1R01CA-115895/CA/NCI NIH HHS/\nResearch Support, N.I.H., Extramural\n2011/01/18 06:00\nInt J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):299-307. doi: 10.1016/j.ijrobp.2010.11.022. Epub 2011 Jan 13.},\n abstract = {PURPOSE: To correlate proton magnetic resonance spectroscopy ((1)H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and (18)F-labeled fluorodeoxyglucose positron emission tomography ([(18)F]FDG PET) of nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging was evaluated for its efficacy in predicting short-term response to treatment. METHODS AND MATERIALS: Metastatic neck nodes were imaged with (1)H-MRS, DCE-MRI, and [(18)F]FDG PET in 16 patients with newly diagnosed HNSCC, before treatment. Short-term patient radiological response was evaluated at 3 to 4 months. Correlations among (1)H-MRS (choline concentration relative to water [Cho/W]), DCE-MRI (volume transfer constant [K(trans)]; volume fraction of the extravascular extracellular space [v(e)]; and redistribution rate constant [k(ep)]), and [(18)F]FDG PET (standard uptake value [SUV] and total lesion glycolysis [TLG]) were calculated using nonparametric Spearman rank correlation. To predict short-term responses, logistic regression analysis was performed. RESULTS: A significant positive correlation was found between Cho/W and TLG (rho = 0.599; p = 0.031). Cho/W correlated negatively with heterogeneity measures of standard deviation std(v(e)) (rho = -0.691; p = 0.004) and std(k(ep)) (rho = -0.704; p = 0.003). Maximum SUV (SUVmax) values correlated strongly with MRI tumor volume (rho = 0.643; p = 0.007). Logistic regression indicated that std(K(trans)) and SUVmean were significant predictors of short-term response (p < 0.07). CONCLUSION: Pretreatment multimodality imaging using (1)H-MRS, DCE-MRI, and [(18)F]FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and [(18)F]FDG PET parameters were predictive of short-term response to treatment.},\n keywords = {Adult\nAged\nAntibodies, Monoclonal, Humanized/therapeutic use\nAntineoplastic Agents/therapeutic use\nBevacizumab\nCarcinoma, Squamous Cell/*metabolism/secondary/therapy\nChemoradiotherapy/methods\nCholine/metabolism\nCisplatin/therapeutic use\nContrast Media\nDiagnostic Imaging/*methods\nExtracellular Space/metabolism\nFeasibility Studies\nFemale\nFluorodeoxyglucose F18/pharmacokinetics\nFluorouracil/therapeutic use\nGadolinium DTPA\nGlucose/metabolism\nGlycolysis\nHead and Neck Neoplasms/*metabolism/pathology/therapy\nHumans\nLymphatic Metastasis\nMagnetic Resonance Imaging/methods\nMagnetic Resonance Spectroscopy/methods\nMale\nMiddle Aged\nNasopharyngeal Neoplasms/metabolism/pathology/therapy\nPositron-Emission Tomography/methods\nProspective Studies\nRadiopharmaceuticals/pharmacokinetics\nRegression Analysis\nStatistics, Nonparametric\nTongue Neoplasms/metabolism/pathology/therapy\nTonsillar Neoplasms/metabolism/pathology/therapy},\n ISSN = {1879-355X (Electronic)\n0360-3016 (Linking)},\n DOI = {10.1016/j.ijrobp.2010.11.022},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/21236594\nhttps://www.redjournal.org/article/S0360-3016(10)03570-4/pdf},\n year = {2012},\n type = {Journal Article}\n}\n\n","author_short":["Jansen, J. F.","Schoder, H.","Lee, N. Y.","Stambuk, H. E.","Wang, Y.","Fury, M. G.","Patel, S. G.","Pfister, D. G.","Shah, J. P.","Koutcher, J. 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