@article{RN139,
   author = {Jansen, J. F. and Schoder, H. and Lee, N. Y. and Wang, Y. and Pfister, D. G. and Fury, M. G. and Stambuk, H. E. and Humm, J. L. and Koutcher, J. A. and Shukla-Dave, A.},
   title = {Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases},
   journal = {Int J Radiat Oncol Biol Phys},
   volume = {77},
   number = {5},
   pages = {1403-10},
   note = {Jansen, Jacobus F A
Schoder, Heiko
Lee, Nancy Y
Wang, Ya
Pfister, David G
Fury, Matthew G
Stambuk, Hilda E
Humm, John L
Koutcher, Jason A
Shukla-Dave, Amita
eng
R01 CA115895/CA/NCI NIH HHS/
R01 CA115895-04/CA/NCI NIH HHS/
1 R01 CA115895/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
2009/11/13 06:00
Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1403-10. doi: 10.1016/j.ijrobp.2009.07.009. Epub 2009 Nov 10.},
   abstract = {PURPOSE: To assess noninvasively the tumor microenvironment of neck nodal metastases in patients with head-and-neck cancer by investigating the relationship between tumor perfusion measured using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and hypoxia measured by (18)F-fluoromisonidazole ((18)F-FMISO) positron emission tomography (PET). METHODS AND MATERIALS: Thirteen newly diagnosed head-and-neck cancer patients with metastatic neck nodes underwent DCE-MRI and (18)F-FMISO PET imaging before chemotherapy and radiotherapy. The matched regions of interests from both modalities were analyzed. To examine the correlations between DCE-MRI parameters and standard uptake value (SUV) measurements from (18)F-FMISO PET, the nonparametric Spearman correlation coefficient was calculated. Furthermore, DCE-MRI parameters were compared between nodes with (18)F-FMISO uptake and nodes with no (18)F-FMISO uptake using Mann-Whitney U tests. RESULTS: For the 13 patients, a total of 18 nodes were analyzed. The nodal size strongly correlated with the (18)F-FMISO SUV (rho = 0.74, p < 0.001). There was a strong negative correlation between the median k(ep) (redistribution rate constant) value (rho = -0.58, p = 0.042) and the (18)F-FMISO SUV. Hypoxic nodes (moderate to severe (18)F-FMISO uptake) had significantly lower median K(trans) (volume transfer constant) (p = 0.049) and median k(ep) (p = 0.027) values than did nonhypoxic nodes (no (18)F-FMISO uptake). CONCLUSION: This initial evaluation of the preliminary results support the hypothesis that in metastatic neck lymph nodes, hypoxic nodes are poorly perfused (i.e., have significantly lower K(trans) and k(ep) values) compared with nonhypoxic nodes.},
   keywords = {Aged
Aged, 80 and over
*Carcinoma, Squamous Cell/diagnostic imaging/metabolism/pathology
*Cell Hypoxia/physiology
Female
*Head and Neck Neoplasms/diagnostic imaging/metabolism/pathology
Humans
*Lymph Nodes/diagnostic imaging/metabolism/pathology
Lymphatic Metastasis
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Misonidazole/analogs & derivatives/pharmacokinetics
Positron-Emission Tomography/*methods
Radiopharmaceuticals/pharmacokinetics
Retrospective Studies
Statistics, Nonparametric},
   ISSN = {1879-355X (Electronic)
0360-3016 (Linking)},
   DOI = {10.1016/j.ijrobp.2009.07.009},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/19906496
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888682/pdf/nihms132225.pdf},
   year = {2010},
   type = {Journal Article}
}

{"_id":"e5XyrLJPCdoDMv6na","bibbaseid":"jansen-schoder-lee-wang-pfister-fury-stambuk-humm-etal-noninvasiveassessmentoftumormicroenvironmentusingdynamiccontrastenhancedmagneticresonanceimagingand18ffluoromisonidazolepositronemissiontomographyimaginginnecknodalmetastases-2010","downloads":0,"creationDate":"2018-08-03T14:29:50.114Z","title":"Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases","author_short":["Jansen, J. F.","Schoder, H.","Lee, N. Y.","Wang, Y.","Pfister, D. G.","Fury, M. G.","Stambuk, H. E.","Humm, J. L.","Koutcher, J. A.","Shukla-Dave, A."],"year":2010,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Schoder"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["N.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Pfister"],"firstnames":["D.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Fury"],"firstnames":["M.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Stambuk"],"firstnames":["H.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Humm"],"firstnames":["J.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Koutcher"],"firstnames":["J.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Shukla-Dave"],"firstnames":["A."],"suffixes":[]}],"title":"Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases","journal":"Int J Radiat Oncol Biol Phys","volume":"77","number":"5","pages":"1403-10","note":"Jansen, Jacobus F A Schoder, Heiko Lee, Nancy Y Wang, Ya Pfister, David G Fury, Matthew G Stambuk, Hilda E Humm, John L Koutcher, Jason A Shukla-Dave, Amita eng R01 CA115895/CA/NCI NIH HHS/ R01 CA115895-04/CA/NCI NIH HHS/ 1 R01 CA115895/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural 2009/11/13 06:00 Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1403-10. doi: 10.1016/j.ijrobp.2009.07.009. Epub 2009 Nov 10.","abstract":"PURPOSE: To assess noninvasively the tumor microenvironment of neck nodal metastases in patients with head-and-neck cancer by investigating the relationship between tumor perfusion measured using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and hypoxia measured by (18)F-fluoromisonidazole ((18)F-FMISO) positron emission tomography (PET). METHODS AND MATERIALS: Thirteen newly diagnosed head-and-neck cancer patients with metastatic neck nodes underwent DCE-MRI and (18)F-FMISO PET imaging before chemotherapy and radiotherapy. The matched regions of interests from both modalities were analyzed. To examine the correlations between DCE-MRI parameters and standard uptake value (SUV) measurements from (18)F-FMISO PET, the nonparametric Spearman correlation coefficient was calculated. Furthermore, DCE-MRI parameters were compared between nodes with (18)F-FMISO uptake and nodes with no (18)F-FMISO uptake using Mann-Whitney U tests. RESULTS: For the 13 patients, a total of 18 nodes were analyzed. The nodal size strongly correlated with the (18)F-FMISO SUV (rho = 0.74, p < 0.001). There was a strong negative correlation between the median k(ep) (redistribution rate constant) value (rho = -0.58, p = 0.042) and the (18)F-FMISO SUV. Hypoxic nodes (moderate to severe (18)F-FMISO uptake) had significantly lower median K(trans) (volume transfer constant) (p = 0.049) and median k(ep) (p = 0.027) values than did nonhypoxic nodes (no (18)F-FMISO uptake). CONCLUSION: This initial evaluation of the preliminary results support the hypothesis that in metastatic neck lymph nodes, hypoxic nodes are poorly perfused (i.e., have significantly lower K(trans) and k(ep) values) compared with nonhypoxic nodes.","keywords":"Aged Aged, 80 and over *Carcinoma, Squamous Cell/diagnostic imaging/metabolism/pathology *Cell Hypoxia/physiology Female *Head and Neck Neoplasms/diagnostic imaging/metabolism/pathology Humans *Lymph Nodes/diagnostic imaging/metabolism/pathology Lymphatic Metastasis Magnetic Resonance Imaging/*methods Male Middle Aged Misonidazole/analogs & derivatives/pharmacokinetics Positron-Emission Tomography/*methods Radiopharmaceuticals/pharmacokinetics Retrospective Studies Statistics, Nonparametric","issn":"1879-355X (Electronic) 0360-3016 (Linking)","doi":"10.1016/j.ijrobp.2009.07.009","url":"http://www.ncbi.nlm.nih.gov/pubmed/19906496 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888682/pdf/nihms132225.pdf","year":"2010","bibtex":"@article{RN139,\n author = {Jansen, J. F. and Schoder, H. and Lee, N. Y. and Wang, Y. and Pfister, D. G. and Fury, M. G. and Stambuk, H. E. and Humm, J. L. and Koutcher, J. A. and Shukla-Dave, A.},\n title = {Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases},\n journal = {Int J Radiat Oncol Biol Phys},\n volume = {77},\n number = {5},\n pages = {1403-10},\n note = {Jansen, Jacobus F A\nSchoder, Heiko\nLee, Nancy Y\nWang, Ya\nPfister, David G\nFury, Matthew G\nStambuk, Hilda E\nHumm, John L\nKoutcher, Jason A\nShukla-Dave, Amita\neng\nR01 CA115895/CA/NCI NIH HHS/\nR01 CA115895-04/CA/NCI NIH HHS/\n1 R01 CA115895/CA/NCI NIH HHS/\nResearch Support, N.I.H., Extramural\n2009/11/13 06:00\nInt J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1403-10. doi: 10.1016/j.ijrobp.2009.07.009. Epub 2009 Nov 10.},\n abstract = {PURPOSE: To assess noninvasively the tumor microenvironment of neck nodal metastases in patients with head-and-neck cancer by investigating the relationship between tumor perfusion measured using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and hypoxia measured by (18)F-fluoromisonidazole ((18)F-FMISO) positron emission tomography (PET). METHODS AND MATERIALS: Thirteen newly diagnosed head-and-neck cancer patients with metastatic neck nodes underwent DCE-MRI and (18)F-FMISO PET imaging before chemotherapy and radiotherapy. The matched regions of interests from both modalities were analyzed. To examine the correlations between DCE-MRI parameters and standard uptake value (SUV) measurements from (18)F-FMISO PET, the nonparametric Spearman correlation coefficient was calculated. Furthermore, DCE-MRI parameters were compared between nodes with (18)F-FMISO uptake and nodes with no (18)F-FMISO uptake using Mann-Whitney U tests. RESULTS: For the 13 patients, a total of 18 nodes were analyzed. The nodal size strongly correlated with the (18)F-FMISO SUV (rho = 0.74, p < 0.001). There was a strong negative correlation between the median k(ep) (redistribution rate constant) value (rho = -0.58, p = 0.042) and the (18)F-FMISO SUV. Hypoxic nodes (moderate to severe (18)F-FMISO uptake) had significantly lower median K(trans) (volume transfer constant) (p = 0.049) and median k(ep) (p = 0.027) values than did nonhypoxic nodes (no (18)F-FMISO uptake). CONCLUSION: This initial evaluation of the preliminary results support the hypothesis that in metastatic neck lymph nodes, hypoxic nodes are poorly perfused (i.e., have significantly lower K(trans) and k(ep) values) compared with nonhypoxic nodes.},\n keywords = {Aged\nAged, 80 and over\n*Carcinoma, Squamous Cell/diagnostic imaging/metabolism/pathology\n*Cell Hypoxia/physiology\nFemale\n*Head and Neck Neoplasms/diagnostic imaging/metabolism/pathology\nHumans\n*Lymph Nodes/diagnostic imaging/metabolism/pathology\nLymphatic Metastasis\nMagnetic Resonance Imaging/*methods\nMale\nMiddle Aged\nMisonidazole/analogs & derivatives/pharmacokinetics\nPositron-Emission Tomography/*methods\nRadiopharmaceuticals/pharmacokinetics\nRetrospective Studies\nStatistics, Nonparametric},\n ISSN = {1879-355X (Electronic)\n0360-3016 (Linking)},\n DOI = {10.1016/j.ijrobp.2009.07.009},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/19906496\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888682/pdf/nihms132225.pdf},\n year = {2010},\n type = {Journal Article}\n}\n\n","author_short":["Jansen, J. 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