@article{RN182,
   author = {Jansen, J. F. and van Bussel, F. C. and van de Haar, H. J. and van Osch, M. J. and Hofman, P. A. and van Boxtel, M. P. and van Oostenbrugge, R. J. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Backes, W. H.},
   title = {Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus},
   journal = {Sci Rep},
   volume = {6},
   number = {1},
   pages = {10},
   note = {Jansen, Jacobus F A
van Bussel, Frank C G
van de Haar, Harm J
van Osch, Matthias J P
Hofman, Paul A M
van Boxtel, Martin P J
van Oostenbrugge, Robert J
Schram, Miranda T
Stehouwer, Coen D A
Wildberger, Joachim E
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
England
2016/12/07 06:00
Sci Rep. 2016 Dec 5;6(1):10. doi: 10.1038/s41598-016-0003-6.},
   abstract = {We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.},
   keywords = {Aged
Anthropometry
*Cerebrovascular Circulation
*Cognition
Diabetes Mellitus, Type 2/*pathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged},
   ISSN = {2045-2322 (Electronic)
2045-2322 (Linking)},
   DOI = {10.1038/s41598-016-0003-6},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27920431
https://www.nature.com/articles/s41598-016-0003-6.pdf},
   year = {2016},
   type = {Journal Article}
}

{"_id":"tafob7Qi8B7aiAwFT","bibbaseid":"jansen-vanbussel-vandehaar-vanosch-hofman-vanboxtel-vanoostenbrugge-schram-etal-cerebralbloodflowbloodsupplyandcognitionintype2diabetesmellitus-2016","downloads":0,"creationDate":"2017-09-02T18:10:13.437Z","title":"Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus","author_short":["Jansen, J. F.","van Bussel, F. C.","van de Haar, H. J.","van Osch, M. J.","Hofman, P. A.","van Boxtel, M. P.","van Oostenbrugge, R. J.","Schram, M. T.","Stehouwer, C. D.","Wildberger, J. E.","Backes, W. H."],"year":2016,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":["van"],"lastnames":["Bussel"],"firstnames":["F.","C."],"suffixes":[]},{"propositions":["van","de"],"lastnames":["Haar"],"firstnames":["H.","J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Osch"],"firstnames":["M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Wildberger"],"firstnames":["J.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus","journal":"Sci Rep","volume":"6","number":"1","pages":"10","note":"Jansen, Jacobus F A van Bussel, Frank C G van de Haar, Harm J van Osch, Matthias J P Hofman, Paul A M van Boxtel, Martin P J van Oostenbrugge, Robert J Schram, Miranda T Stehouwer, Coen D A Wildberger, Joachim E Backes, Walter H eng Research Support, Non-U.S. Gov't England 2016/12/07 06:00 Sci Rep. 2016 Dec 5;6(1):10. doi: 10.1038/s41598-016-0003-6.","abstract":"We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.","keywords":"Aged Anthropometry *Cerebrovascular Circulation *Cognition Diabetes Mellitus, Type 2/*pathology Female Humans Magnetic Resonance Imaging Male Middle Aged","issn":"2045-2322 (Electronic) 2045-2322 (Linking)","doi":"10.1038/s41598-016-0003-6","url":"http://www.ncbi.nlm.nih.gov/pubmed/27920431 https://www.nature.com/articles/s41598-016-0003-6.pdf","year":"2016","bibtex":"@article{RN182,\n author = {Jansen, J. F. and van Bussel, F. C. and van de Haar, H. J. and van Osch, M. J. and Hofman, P. A. and van Boxtel, M. P. and van Oostenbrugge, R. J. and Schram, M. T. and Stehouwer, C. D. and Wildberger, J. E. and Backes, W. H.},\n title = {Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus},\n journal = {Sci Rep},\n volume = {6},\n number = {1},\n pages = {10},\n note = {Jansen, Jacobus F A\nvan Bussel, Frank C G\nvan de Haar, Harm J\nvan Osch, Matthias J P\nHofman, Paul A M\nvan Boxtel, Martin P J\nvan Oostenbrugge, Robert J\nSchram, Miranda T\nStehouwer, Coen D A\nWildberger, Joachim E\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\nEngland\n2016/12/07 06:00\nSci Rep. 2016 Dec 5;6(1):10. doi: 10.1038/s41598-016-0003-6.},\n abstract = {We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.},\n keywords = {Aged\nAnthropometry\n*Cerebrovascular Circulation\n*Cognition\nDiabetes Mellitus, Type 2/*pathology\nFemale\nHumans\nMagnetic Resonance Imaging\nMale\nMiddle Aged},\n ISSN = {2045-2322 (Electronic)\n2045-2322 (Linking)},\n DOI = {10.1038/s41598-016-0003-6},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/27920431\nhttps://www.nature.com/articles/s41598-016-0003-6.pdf},\n year = {2016},\n type = {Journal Article}\n}\n\n","author_short":["Jansen, J. F.","van Bussel, F. C.","van de Haar, H. J.","van Osch, M. J.","Hofman, P. 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