@article{RN168,
   author = {Jansen, J. F. and van der Kruijs, S. J. and Vlooswijk, M. C. and Majoie, H. M. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Quantitative MR and cognitive impairment in cryptogenic localisation-related epilepsy},
   journal = {Epileptic Disord},
   volume = {16},
   number = {3},
   pages = {318-27},
   note = {Jansen, Jacobus Fa
van der Kruijs, Sylvie Jm
Vlooswijk, Marielle Cg
Majoie, Hj Marian
Hofman, Paul Am
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
France
2014/07/19 06:00
Epileptic Disord. 2014 Sep;16(3):318-27. doi: 10.1684/epd.2014.0665.},
   abstract = {For patients with chronic cryptogenic localisation-related epilepsy (CLRE), conventional MRI does not provide measures to discern between patients with or without cognitive complaints. We investigated, in a preliminary study, whether it is possible to detect cerebral biomarkers of cognitive impairment in patients with CLRE using sensitive quantitative MRI techniques. Neuropsychological assessment and quantitative 3.0 T MRI, comprising T2 relaxometry, diffusion tensor imaging, and spectroscopic imaging, were applied to 35 patients with CLRE and 21 healthy controls. Analysis included the left and right hippocampi, and frontal and temporal lobes. Differences between the groups and correlations with cognitive and clinical characteristics were assessed. Patients with epilepsy scored significantly worse on cognitive tasks compared to healthy controls. Significantly larger CSF fractions in the hippocampi and left temporal lobe, a longer T2 relaxation time in the left hippocampus, and a significantly higher concentration of glutamate/glutamine in the left frontal lobe were observed in patients with epilepsy. Moreover, poor memory performance was significantly correlated with larger CSF fractions in the right hippocampus and left temporal lobe in patients. In the temporal lobe, an association between subtle changes in morphology (indicative of atrophy) and memory performance was found, consistent with previous literature. These results may help to explain the alterations in brain functioning in patients with epilepsy.},
   keywords = {Adult
Cognition
Cognition Disorders/etiology/*pathology/psychology
Diffusion Tensor Imaging
Epilepsy/complications/*pathology/psychology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Spectroscopy
Male
Middle Aged
Neuropsychological Tests
MR spectroscopy
MRI-negative
localization-related epilepsy
memory},
   ISSN = {1294-9361 (Print)
1294-9361 (Linking)},
   DOI = {10.1684/epd.2014.0665},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25036856
http://www.jle.com/download/epd-302156-25932-quantitative_mr_and_cognitive_impairment_in_cryptogenic_localisation_related_epilepsy-a.pdf},
   year = {2014},
   type = {Journal Article}
}

{"_id":"p54nj5G9Hdogtdnf3","bibbaseid":"jansen-vanderkruijs-vlooswijk-majoie-hofman-aldenkamp-backes-quantitativemrandcognitiveimpairmentincryptogeniclocalisationrelatedepilepsy-2014","downloads":0,"creationDate":"2017-09-02T18:10:13.485Z","title":"Quantitative MR and cognitive impairment in cryptogenic localisation-related epilepsy","author_short":["Jansen, J. F.","van der Kruijs, S. J.","Vlooswijk, M. C.","Majoie, H. M.","Hofman, P. A.","Aldenkamp, A. P.","Backes, W. H."],"year":2014,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kruijs"],"firstnames":["S.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Majoie"],"firstnames":["H.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Quantitative MR and cognitive impairment in cryptogenic localisation-related epilepsy","journal":"Epileptic Disord","volume":"16","number":"3","pages":"318-27","note":"Jansen, Jacobus Fa van der Kruijs, Sylvie Jm Vlooswijk, Marielle Cg Majoie, Hj Marian Hofman, Paul Am Aldenkamp, Albert P Backes, Walter H eng Research Support, Non-U.S. Gov't France 2014/07/19 06:00 Epileptic Disord. 2014 Sep;16(3):318-27. doi: 10.1684/epd.2014.0665.","abstract":"For patients with chronic cryptogenic localisation-related epilepsy (CLRE), conventional MRI does not provide measures to discern between patients with or without cognitive complaints. We investigated, in a preliminary study, whether it is possible to detect cerebral biomarkers of cognitive impairment in patients with CLRE using sensitive quantitative MRI techniques. Neuropsychological assessment and quantitative 3.0 T MRI, comprising T2 relaxometry, diffusion tensor imaging, and spectroscopic imaging, were applied to 35 patients with CLRE and 21 healthy controls. Analysis included the left and right hippocampi, and frontal and temporal lobes. Differences between the groups and correlations with cognitive and clinical characteristics were assessed. Patients with epilepsy scored significantly worse on cognitive tasks compared to healthy controls. Significantly larger CSF fractions in the hippocampi and left temporal lobe, a longer T2 relaxation time in the left hippocampus, and a significantly higher concentration of glutamate/glutamine in the left frontal lobe were observed in patients with epilepsy. Moreover, poor memory performance was significantly correlated with larger CSF fractions in the right hippocampus and left temporal lobe in patients. In the temporal lobe, an association between subtle changes in morphology (indicative of atrophy) and memory performance was found, consistent with previous literature. These results may help to explain the alterations in brain functioning in patients with epilepsy.","keywords":"Adult Cognition Cognition Disorders/etiology/*pathology/psychology Diffusion Tensor Imaging Epilepsy/complications/*pathology/psychology Female Humans Image Processing, Computer-Assisted Magnetic Resonance Spectroscopy Male Middle Aged Neuropsychological Tests MR spectroscopy MRI-negative localization-related epilepsy memory","issn":"1294-9361 (Print) 1294-9361 (Linking)","doi":"10.1684/epd.2014.0665","url":"http://www.ncbi.nlm.nih.gov/pubmed/25036856 http://www.jle.com/download/epd-302156-25932-quantitative_mr_and_cognitive_impairment_in_cryptogenic_localisation_related_epilepsy-a.pdf","year":"2014","bibtex":"@article{RN168,\n author = {Jansen, J. F. and van der Kruijs, S. J. and Vlooswijk, M. C. and Majoie, H. M. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},\n title = {Quantitative MR and cognitive impairment in cryptogenic localisation-related epilepsy},\n journal = {Epileptic Disord},\n volume = {16},\n number = {3},\n pages = {318-27},\n note = {Jansen, Jacobus Fa\nvan der Kruijs, Sylvie Jm\nVlooswijk, Marielle Cg\nMajoie, Hj Marian\nHofman, Paul Am\nAldenkamp, Albert P\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\nFrance\n2014/07/19 06:00\nEpileptic Disord. 2014 Sep;16(3):318-27. doi: 10.1684/epd.2014.0665.},\n abstract = {For patients with chronic cryptogenic localisation-related epilepsy (CLRE), conventional MRI does not provide measures to discern between patients with or without cognitive complaints. We investigated, in a preliminary study, whether it is possible to detect cerebral biomarkers of cognitive impairment in patients with CLRE using sensitive quantitative MRI techniques. Neuropsychological assessment and quantitative 3.0 T MRI, comprising T2 relaxometry, diffusion tensor imaging, and spectroscopic imaging, were applied to 35 patients with CLRE and 21 healthy controls. Analysis included the left and right hippocampi, and frontal and temporal lobes. Differences between the groups and correlations with cognitive and clinical characteristics were assessed. Patients with epilepsy scored significantly worse on cognitive tasks compared to healthy controls. Significantly larger CSF fractions in the hippocampi and left temporal lobe, a longer T2 relaxation time in the left hippocampus, and a significantly higher concentration of glutamate/glutamine in the left frontal lobe were observed in patients with epilepsy. Moreover, poor memory performance was significantly correlated with larger CSF fractions in the right hippocampus and left temporal lobe in patients. In the temporal lobe, an association between subtle changes in morphology (indicative of atrophy) and memory performance was found, consistent with previous literature. These results may help to explain the alterations in brain functioning in patients with epilepsy.},\n keywords = {Adult\nCognition\nCognition Disorders/etiology/*pathology/psychology\nDiffusion Tensor Imaging\nEpilepsy/complications/*pathology/psychology\nFemale\nHumans\nImage Processing, Computer-Assisted\nMagnetic Resonance Spectroscopy\nMale\nMiddle Aged\nNeuropsychological Tests\nMR spectroscopy\nMRI-negative\nlocalization-related epilepsy\nmemory},\n ISSN = {1294-9361 (Print)\n1294-9361 (Linking)},\n DOI = {10.1684/epd.2014.0665},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/25036856\nhttp://www.jle.com/download/epd-302156-25932-quantitative_mr_and_cognitive_impairment_in_cryptogenic_localisation_related_epilepsy-a.pdf},\n year = {2014},\n type = {Journal Article}\n}\n\n","author_short":["Jansen, J. 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