@article{RN132,
   author = {Jansen, J. F. and Vlooswijk, M. C. and de Baets, M. H. and de Krom, M. C. and Rieckmann, P. and Backes, W. H. and Aldenkamp, A. P. and Group, Segaed Study},
   title = {Cognitive fMRI and soluble telencephalin assessment in patients with localization-related epilepsy},
   journal = {Acta Neurol Scand},
   volume = {118},
   number = {4},
   pages = {232-9},
   note = {Jansen, J F A
Vlooswijk, M C G
de Baets, M H
de Krom, M C T F M
Rieckmann, P
Backes, W H
Aldenkamp, A P
eng
Denmark
2008/05/08 09:00
Acta Neurol Scand. 2008 Oct;118(4):232-9. doi: 10.1111/j.1600-0404.2008.01005.x. Epub 2008 Apr 30.},
   abstract = {Objectives - The use of telencephalin as a possible marker for altered cortical function as demonstrated by functional MRI was investigated in a pilot study with 16 patients with localization-related epilepsy and secondarily generalized seizures. Materials and methods - Functional MRI of verbal working memory performance (Sternberg paradigm) and self-regulatory control processes (Stroop paradigm) was used to examine cortical activation in 16 patients with localization-related epilepsy and secondarily generalized seizures. Additionally, blood serum concentrations of soluble telencephalin (marker for neuronal damage) were determined. Results - In three patients (one temporal and two frontal focus), telencephalin was detected. All three patients had lower functional MRI activation in the frontotemporal region (P = 0.04), but not in other regions (P > 0.35) compared with patients without detectable telencephalin. Additionally, an association of levetiracetam and frontotemporal activation was observed. Conclusions - These preliminary data in a heterogeneous group suggest an association between decreased frontotemporal activation on fMRI and both detectable telencephalin serum levels and levetiracetam use. Future longitudinal studies with larger patient groups are required to confirm these observations. It is hypothesized that altered local function of the frontotemporal cortex in localization-related epilepsy might be better predicted by the biochemical marker telencephalin than epilepsy characteristics such as seizure focus.},
   keywords = {Adult
Anticonvulsants/therapeutic use
Biomarkers/blood
Brain/drug effects/*pathology
Cell Adhesion Molecules/*blood
Epilepsies, Partial/*blood/drug therapy/*pathology
Female
Humans
Levetiracetam
*Magnetic Resonance Imaging
Male
Middle Aged
Nerve Tissue Proteins/*blood
Neuropsychological Tests
Pilot Projects
Piracetam/analogs & derivatives/therapeutic use},
   ISSN = {1600-0404 (Electronic)
0001-6314 (Linking)},
   DOI = {10.1111/j.1600-0404.2008.01005.x},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18460045
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0404.2008.01005.x},
   year = {2008},
   type = {Journal Article}
}

{"_id":"WQhwnGYzLMT5RtxBT","bibbaseid":"jansen-vlooswijk-debaets-dekrom-rieckmann-backes-aldenkamp-group-cognitivefmriandsolubletelencephalinassessmentinpatientswithlocalizationrelatedepilepsy-2008","downloads":0,"creationDate":"2018-08-03T14:29:50.126Z","title":"Cognitive fMRI and soluble telencephalin assessment in patients with localization-related epilepsy","author_short":["Jansen, J. F.","Vlooswijk, M. C.","de Baets, M. H.","de Krom, M. C.","Rieckmann, P.","Backes, W. H.","Aldenkamp, A. P.","Group, S. S."],"year":2008,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":["de"],"lastnames":["Baets"],"firstnames":["M.","H."],"suffixes":[]},{"propositions":["de"],"lastnames":["Krom"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Rieckmann"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Group"],"firstnames":["Segaed","Study"],"suffixes":[]}],"title":"Cognitive fMRI and soluble telencephalin assessment in patients with localization-related epilepsy","journal":"Acta Neurol Scand","volume":"118","number":"4","pages":"232-9","note":"Jansen, J F A Vlooswijk, M C G de Baets, M H de Krom, M C T F M Rieckmann, P Backes, W H Aldenkamp, A P eng Denmark 2008/05/08 09:00 Acta Neurol Scand. 2008 Oct;118(4):232-9. doi: 10.1111/j.1600-0404.2008.01005.x. Epub 2008 Apr 30.","abstract":"Objectives - The use of telencephalin as a possible marker for altered cortical function as demonstrated by functional MRI was investigated in a pilot study with 16 patients with localization-related epilepsy and secondarily generalized seizures. Materials and methods - Functional MRI of verbal working memory performance (Sternberg paradigm) and self-regulatory control processes (Stroop paradigm) was used to examine cortical activation in 16 patients with localization-related epilepsy and secondarily generalized seizures. Additionally, blood serum concentrations of soluble telencephalin (marker for neuronal damage) were determined. Results - In three patients (one temporal and two frontal focus), telencephalin was detected. All three patients had lower functional MRI activation in the frontotemporal region (P = 0.04), but not in other regions (P > 0.35) compared with patients without detectable telencephalin. Additionally, an association of levetiracetam and frontotemporal activation was observed. Conclusions - These preliminary data in a heterogeneous group suggest an association between decreased frontotemporal activation on fMRI and both detectable telencephalin serum levels and levetiracetam use. Future longitudinal studies with larger patient groups are required to confirm these observations. It is hypothesized that altered local function of the frontotemporal cortex in localization-related epilepsy might be better predicted by the biochemical marker telencephalin than epilepsy characteristics such as seizure focus.","keywords":"Adult Anticonvulsants/therapeutic use Biomarkers/blood Brain/drug effects/*pathology Cell Adhesion Molecules/*blood Epilepsies, Partial/*blood/drug therapy/*pathology Female Humans Levetiracetam *Magnetic Resonance Imaging Male Middle Aged Nerve Tissue Proteins/*blood Neuropsychological Tests Pilot Projects Piracetam/analogs & derivatives/therapeutic use","issn":"1600-0404 (Electronic) 0001-6314 (Linking)","doi":"10.1111/j.1600-0404.2008.01005.x","url":"http://www.ncbi.nlm.nih.gov/pubmed/18460045 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0404.2008.01005.x","year":"2008","bibtex":"@article{RN132,\n author = {Jansen, J. F. and Vlooswijk, M. C. and de Baets, M. H. and de Krom, M. C. and Rieckmann, P. and Backes, W. H. and Aldenkamp, A. P. and Group, Segaed Study},\n title = {Cognitive fMRI and soluble telencephalin assessment in patients with localization-related epilepsy},\n journal = {Acta Neurol Scand},\n volume = {118},\n number = {4},\n pages = {232-9},\n note = {Jansen, J F A\nVlooswijk, M C G\nde Baets, M H\nde Krom, M C T F M\nRieckmann, P\nBackes, W H\nAldenkamp, A P\neng\nDenmark\n2008/05/08 09:00\nActa Neurol Scand. 2008 Oct;118(4):232-9. doi: 10.1111/j.1600-0404.2008.01005.x. Epub 2008 Apr 30.},\n abstract = {Objectives - The use of telencephalin as a possible marker for altered cortical function as demonstrated by functional MRI was investigated in a pilot study with 16 patients with localization-related epilepsy and secondarily generalized seizures. Materials and methods - Functional MRI of verbal working memory performance (Sternberg paradigm) and self-regulatory control processes (Stroop paradigm) was used to examine cortical activation in 16 patients with localization-related epilepsy and secondarily generalized seizures. Additionally, blood serum concentrations of soluble telencephalin (marker for neuronal damage) were determined. Results - In three patients (one temporal and two frontal focus), telencephalin was detected. All three patients had lower functional MRI activation in the frontotemporal region (P = 0.04), but not in other regions (P > 0.35) compared with patients without detectable telencephalin. Additionally, an association of levetiracetam and frontotemporal activation was observed. Conclusions - These preliminary data in a heterogeneous group suggest an association between decreased frontotemporal activation on fMRI and both detectable telencephalin serum levels and levetiracetam use. Future longitudinal studies with larger patient groups are required to confirm these observations. It is hypothesized that altered local function of the frontotemporal cortex in localization-related epilepsy might be better predicted by the biochemical marker telencephalin than epilepsy characteristics such as seizure focus.},\n keywords = {Adult\nAnticonvulsants/therapeutic use\nBiomarkers/blood\nBrain/drug effects/*pathology\nCell Adhesion Molecules/*blood\nEpilepsies, Partial/*blood/drug therapy/*pathology\nFemale\nHumans\nLevetiracetam\n*Magnetic Resonance Imaging\nMale\nMiddle Aged\nNerve Tissue Proteins/*blood\nNeuropsychological Tests\nPilot Projects\nPiracetam/analogs & derivatives/therapeutic use},\n ISSN = {1600-0404 (Electronic)\n0001-6314 (Linking)},\n DOI = {10.1111/j.1600-0404.2008.01005.x},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/18460045\nhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0404.2008.01005.x},\n year = {2008},\n type = {Journal Article}\n}\n\n","author_short":["Jansen, J. F.","Vlooswijk, M. C.","de Baets, M. H.","de Krom, M. 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