Evolutionary Screening of Biomimetic Coatings for Selective Detection of Explosives

Evolutionary Screening of Biomimetic Coatings for Selective Detection of Explosives. Jaworski, J. W., Raorane, D., Huh, J. H., Majumdar, A., & Lee, S. Langmuir, 24:4938-4943, May 1, 2008, 2008.

Paper abstract bibtex

Susceptibility of chemical sensors to false positive signals remains a common drawback due to insufficient sensor coating selectivity. By mimicking biology, we have demonstrated the use of sequence-specific biopolymers to generate highly selective receptors for trinitrotoluene and 2,4-dinitrotoluene. Using mutational analysis, we show that the identified binding peptides recognize the target substrate through multivalent binding with key side chain amino acid elements. Additionally, our peptide-based receptors embedded in a hydrogel show selective binding to target molecules in the gas phase. These experiments demonstrate the technique of receptor screening in liquid to be translated to selective gas-phase target binding, potentially impacting the design of a new class of sensor coatings.

@article {565,
	title = {Evolutionary Screening of Biomimetic Coatings for Selective Detection of Explosives},
	journal = {Langmuir},
	volume = {24},
	year = {2008},
	month = {May 1, 2008},
	pages = {4938-4943},
	abstract = {Susceptibility of chemical sensors to false positive signals remains a common drawback due to insufficient sensor coating selectivity. By mimicking biology, we have demonstrated the use of sequence-specific biopolymers to generate highly selective receptors for trinitrotoluene and 2,4-dinitrotoluene. Using mutational analysis, we show that the identified binding peptides recognize the target substrate through multivalent binding with key side chain amino acid elements. Additionally, our peptide-based receptors embedded in a hydrogel show selective binding to target molecules in the gas phase. These experiments demonstrate the technique of receptor screening in liquid to be translated to selective gas-phase target binding, potentially impacting the design of a new class of sensor coatings.},
	isbn = {0743-7463},
	url = {http://dx.doi.org/10.1021/la7035289},
	author = {Jaworski, Justyn W. and Raorane, Digvijay and Huh, Jin H. and Majumdar, Arunava and Lee, Seung-Wuk}
}

Downloads: 0