Effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery. Jácomo, A. D N, Carmona, F., Matsuno, A. K, Manso, P. H, & Carlotti, A. P C P Infection Control & Hospital Epidemiology, 32(6):591–596, June, 2011. ![Effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OBJECTIVE:To evaluate the effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia and ventilator-associated pneumonia (VAP) in children undergoing cardiac surgery. DESIGN:Prospective, randomized, double-blind, placebo-controlled trial. SETTING:Pediatric intensive care unit (PICU) at a tertiary care hospital. PATIENTS:One hundred sixty children undergoing surgery for congenital heart disease, randomized into 2 groups: chlorhexidine (n = 87) and control (n = 73). INTERVENTIONS:Oral hygiene with 0.12% chlorhexidine gluconate or placebo preoperatively and twice a day postoperatively until PICU discharge or death. RESULTS:Patients in experimental and control groups had similar ages (median, 12.2 vs 10.8 months; P = .72) and risk adjustment for congenital heart surgery 1 score distribution (66% in category 1 or 2 in both groups; P = .17). The incidence of nosocomial pneumonia was 29.8% versus 24.6% (P = .46) and the incidence of VAP was 18.3% versus 15% (P = .57) in the chlorhexidine and the control group, respectively. There was no difference in intubation time (P = .34), need for reintubation (P = .37), time interval between hospitalization and nosocomial pneumonia diagnosis (P = .63), time interval between surgery and nosocomial pneumonia diagnosis (P = .10), and time on antibiotics (P = .77) and vasoactive drugs (P = .16) between groups. Median length of PICU stay (3 vs 4 days; P = .53), median length of hospital stay (12 vs 11 days; P = .67), and 28-day mortality (5.7% vs 6.8%; P = .77) were also similar in the chlorhexidine and the control group. CONCLUSIONS:Oral hygiene with 0.12% chlorhexidine gluconate did not reduce the incidence of nosocomial pneumonia and VAP in children undergoing cardiac surgery. TRIAL REGISTRATION:ClinicalTrials.gov identifier: NCT00829842 .
@article{jacomo_effect_2011,
title = {Effect of oral hygiene with 0.12\% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery},
volume = {32},
url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21558772&retmode=ref&cmd=prlinks},
doi = {10.1086/660018},
abstract = {OBJECTIVE:To evaluate the effect of oral hygiene with 0.12\% chlorhexidine gluconate on the incidence of nosocomial pneumonia and ventilator-associated pneumonia (VAP) in children undergoing cardiac surgery. DESIGN:Prospective, randomized, double-blind, placebo-controlled trial. SETTING:Pediatric intensive care unit (PICU) at a tertiary care hospital. PATIENTS:One hundred sixty children undergoing surgery for congenital heart disease, randomized into 2 groups: chlorhexidine (n = 87) and control (n = 73). INTERVENTIONS:Oral hygiene with 0.12\% chlorhexidine gluconate or placebo preoperatively and twice a day postoperatively until PICU discharge or death. RESULTS:Patients in experimental and control groups had similar ages (median, 12.2 vs 10.8 months; P = .72) and risk adjustment for congenital heart surgery 1 score distribution (66\% in category 1 or 2 in both groups; P = .17). The incidence of nosocomial pneumonia was 29.8\% versus 24.6\% (P = .46) and the incidence of VAP was 18.3\% versus 15\% (P = .57) in the chlorhexidine and the control group, respectively. There was no difference in intubation time (P = .34), need for reintubation (P = .37), time interval between hospitalization and nosocomial pneumonia diagnosis (P = .63), time interval between surgery and nosocomial pneumonia diagnosis (P = .10), and time on antibiotics (P = .77) and vasoactive drugs (P = .16) between groups. Median length of PICU stay (3 vs 4 days; P = .53), median length of hospital stay (12 vs 11 days; P = .67), and 28-day mortality (5.7\% vs 6.8\%; P = .77) were also similar in the chlorhexidine and the control group. CONCLUSIONS:Oral hygiene with 0.12\% chlorhexidine gluconate did not reduce the incidence of nosocomial pneumonia and VAP in children undergoing cardiac surgery. TRIAL REGISTRATION:ClinicalTrials.gov identifier: NCT00829842 .},
number = {6},
journal = {Infection Control \& Hospital Epidemiology},
author = {Jácomo, Andréa D N and Carmona, Fabio and Matsuno, Alessandra K and Manso, Paulo H and Carlotti, Ana P C P},
month = jun,
year = {2011},
pages = {591--596},
}
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P C P"],"year":2011,"bibtype":"article","biburl":"http://bibbase.org/zotero-group/gxu917/1345589","bibdata":{"bibtype":"article","type":"article","title":"Effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery","volume":"32","url":"http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21558772&retmode=ref&cmd=prlinks","doi":"10.1086/660018","abstract":"OBJECTIVE:To evaluate the effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia and ventilator-associated pneumonia (VAP) in children undergoing cardiac surgery. DESIGN:Prospective, randomized, double-blind, placebo-controlled trial. SETTING:Pediatric intensive care unit (PICU) at a tertiary care hospital. PATIENTS:One hundred sixty children undergoing surgery for congenital heart disease, randomized into 2 groups: chlorhexidine (n = 87) and control (n = 73). INTERVENTIONS:Oral hygiene with 0.12% chlorhexidine gluconate or placebo preoperatively and twice a day postoperatively until PICU discharge or death. RESULTS:Patients in experimental and control groups had similar ages (median, 12.2 vs 10.8 months; P = .72) and risk adjustment for congenital heart surgery 1 score distribution (66% in category 1 or 2 in both groups; P = .17). The incidence of nosocomial pneumonia was 29.8% versus 24.6% (P = .46) and the incidence of VAP was 18.3% versus 15% (P = .57) in the chlorhexidine and the control group, respectively. There was no difference in intubation time (P = .34), need for reintubation (P = .37), time interval between hospitalization and nosocomial pneumonia diagnosis (P = .63), time interval between surgery and nosocomial pneumonia diagnosis (P = .10), and time on antibiotics (P = .77) and vasoactive drugs (P = .16) between groups. Median length of PICU stay (3 vs 4 days; P = .53), median length of hospital stay (12 vs 11 days; P = .67), and 28-day mortality (5.7% vs 6.8%; P = .77) were also similar in the chlorhexidine and the control group. CONCLUSIONS:Oral hygiene with 0.12% chlorhexidine gluconate did not reduce the incidence of nosocomial pneumonia and VAP in children undergoing cardiac surgery. TRIAL REGISTRATION:ClinicalTrials.gov identifier: NCT00829842 .","number":"6","journal":"Infection Control & Hospital Epidemiology","author":[{"propositions":[],"lastnames":["Jácomo"],"firstnames":["Andréa","D","N"],"suffixes":[]},{"propositions":[],"lastnames":["Carmona"],"firstnames":["Fabio"],"suffixes":[]},{"propositions":[],"lastnames":["Matsuno"],"firstnames":["Alessandra","K"],"suffixes":[]},{"propositions":[],"lastnames":["Manso"],"firstnames":["Paulo","H"],"suffixes":[]},{"propositions":[],"lastnames":["Carlotti"],"firstnames":["Ana","P","C","P"],"suffixes":[]}],"month":"June","year":"2011","pages":"591–596","bibtex":"@article{jacomo_effect_2011,\n\ttitle = {Effect of oral hygiene with 0.12\\% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery},\n\tvolume = {32},\n\turl = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21558772&retmode=ref&cmd=prlinks},\n\tdoi = {10.1086/660018},\n\tabstract = {OBJECTIVE:To evaluate the effect of oral hygiene with 0.12\\% chlorhexidine gluconate on the incidence of nosocomial pneumonia and ventilator-associated pneumonia (VAP) in children undergoing cardiac surgery. DESIGN:Prospective, randomized, double-blind, placebo-controlled trial. SETTING:Pediatric intensive care unit (PICU) at a tertiary care hospital. PATIENTS:One hundred sixty children undergoing surgery for congenital heart disease, randomized into 2 groups: chlorhexidine (n = 87) and control (n = 73). INTERVENTIONS:Oral hygiene with 0.12\\% chlorhexidine gluconate or placebo preoperatively and twice a day postoperatively until PICU discharge or death. RESULTS:Patients in experimental and control groups had similar ages (median, 12.2 vs 10.8 months; P = .72) and risk adjustment for congenital heart surgery 1 score distribution (66\\% in category 1 or 2 in both groups; P = .17). The incidence of nosocomial pneumonia was 29.8\\% versus 24.6\\% (P = .46) and the incidence of VAP was 18.3\\% versus 15\\% (P = .57) in the chlorhexidine and the control group, respectively. There was no difference in intubation time (P = .34), need for reintubation (P = .37), time interval between hospitalization and nosocomial pneumonia diagnosis (P = .63), time interval between surgery and nosocomial pneumonia diagnosis (P = .10), and time on antibiotics (P = .77) and vasoactive drugs (P = .16) between groups. Median length of PICU stay (3 vs 4 days; P = .53), median length of hospital stay (12 vs 11 days; P = .67), and 28-day mortality (5.7\\% vs 6.8\\%; P = .77) were also similar in the chlorhexidine and the control group. CONCLUSIONS:Oral hygiene with 0.12\\% chlorhexidine gluconate did not reduce the incidence of nosocomial pneumonia and VAP in children undergoing cardiac surgery. 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