Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice. Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso, M., Rauvala, H., Swartz, M., Fukumura, D., Jain, R. K., & Alitalo, K. Science, 276(5317):1423–1425, May, 1997.
Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice [link]Paper  doi  abstract   bibtex   
No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but not vascular, endothelial proliferation and vessel enlargement. Thus, VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis. VEGF-C may play a role in disorders involving the lymphatic system and may be of potential use in therapeutic lymphangiogenesis.
@article{jeltsch_hyperplasia_1997,
	title = {Hyperplasia of {Lymphatic} {Vessels} in {VEGF}-{C} {Transgenic} {Mice}},
	volume = {276},
	issn = {0036-8075, 1095-9203},
	url = {http://dx.doi.org/10.1126/science.276.5317.1423},
	doi = {10.1126/science.276.5317.1423},
	abstract = {No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but not vascular, endothelial proliferation and vessel enlargement. Thus, VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis. VEGF-C may play a role in disorders involving the lymphatic system and may be of potential use in therapeutic lymphangiogenesis.},
	language = {en},
	number = {5317},
	urldate = {2012-09-22},
	journal = {Science},
	author = {Jeltsch, Michael and Kaipainen, Arja and Joukov, Vladimir and Meng, Xiaojuan and Lakso, Merja and Rauvala, Heikki and Swartz, Melody and Fukumura, Dai and Jain, Rakesh K. and Alitalo, Kari},
	month = may,
	year = {1997},
	pages = {1423--1425},
}

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