Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease. Jhun, E. H., Hu, X., Sadhu, N., Yao, Y., He, Y., Wilkie, D. J., Molokie, R. E., & Wang, Z. J. Pharmacogenomics, 19(5):401–411, April, 2018. MAG ID: 2795485534doi abstract bibtex Aim: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genesTRPV1 and TRPA1with pain in SCD patients.
@article{jhun_transient_2018,
title = {Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease.},
volume = {19},
doi = {10.2217/pgs-2017-0198},
abstract = {Aim:
Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genesTRPV1 and TRPA1with pain in SCD patients.},
number = {5},
journal = {Pharmacogenomics},
author = {Jhun, Ellie H. and Hu, Xiaoyu and Sadhu, Nilanjana and Yao, Yingwei and He, Ying and Wilkie, Diana J. and Molokie, Robert E. and Wang, Zaijie Jim},
month = apr,
year = {2018},
doi = {10.2217/pgs-2017-0198},
pmcid = {6275563},
pmid = {29620434},
note = {MAG ID: 2795485534},
pages = {401--411},
}
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