@article{RN189,
   author = {Jiang, C. and Davalos, R. V. and Bischof, J. C.},
   title = {A review of basic to clinical studies of irreversible electroporation therapy},
   journal = {IEEE Trans Biomed Eng},
   volume = {62},
   number = {1},
   pages = {4-20},
   note = {1558-2531
Jiang, Chunlan
Davalos, Rafael V
Bischof, John C
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
United States
2014/11/13
IEEE Trans Biomed Eng. 2015 Jan;62(1):4-20. doi: 10.1109/TBME.2014.2367543.},
   abstract = {The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over the past decade. As a nonthermal therapy, IRE offers several potential benefits over other focal therapies, which include 1) short treatment delivery time, 2) reduced collateral thermal injury, and 3) the ability to treat tumors adjacent to major blood vessels. These advantages have stimulated widespread interest in basic through clinical studies of IRE. For instance, many in vitro and in vivo studies now identify treatment planning protocols (IRE threshold, pulse parameters, etc.), electrode delivery (electrode design, placement, intraoperative imaging methods, etc.), injury evaluation (methods and timing), and treatment efficacy in different cancer models. Therefore, this study reviews the in vitro, translational, and clinical studies of IRE cancer therapy based on major experimental studies particularly within the past decade. Further, this study provides organized data and facts to assist further research, optimization, and clinical applications of IRE.},
   keywords = {Animals
Cell Membrane Permeability/*radiation effects
Electric Stimulation Therapy/methods
Electrochemotherapy/*methods
Electromagnetic Fields
Evidence-Based Medicine
Humans
Models, Biological
Neoplasms/pathology/*physiopathology/*therapy
Neovascularization, Pathologic/*pathology/physiopathology/*therapy
Treatment Outcome},
   ISSN = {0018-9294},
   DOI = {10.1109/tbme.2014.2367543},
   year = {2015},
   type = {Journal Article}
}

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Review United States 2014/11/13 IEEE Trans Biomed Eng. 2015 Jan;62(1):4-20. doi: 10.1109/TBME.2014.2367543.","abstract":"The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over the past decade. As a nonthermal therapy, IRE offers several potential benefits over other focal therapies, which include 1) short treatment delivery time, 2) reduced collateral thermal injury, and 3) the ability to treat tumors adjacent to major blood vessels. These advantages have stimulated widespread interest in basic through clinical studies of IRE. For instance, many in vitro and in vivo studies now identify treatment planning protocols (IRE threshold, pulse parameters, etc.), electrode delivery (electrode design, placement, intraoperative imaging methods, etc.), injury evaluation (methods and timing), and treatment efficacy in different cancer models. Therefore, this study reviews the in vitro, translational, and clinical studies of IRE cancer therapy based on major experimental studies particularly within the past decade. Further, this study provides organized data and facts to assist further research, optimization, and clinical applications of IRE.","keywords":"Animals Cell Membrane Permeability/*radiation effects Electric Stimulation Therapy/methods Electrochemotherapy/*methods Electromagnetic Fields Evidence-Based Medicine Humans Models, Biological Neoplasms/pathology/*physiopathology/*therapy Neovascularization, Pathologic/*pathology/physiopathology/*therapy Treatment Outcome","issn":"0018-9294","doi":"10.1109/tbme.2014.2367543","year":"2015","bibtex":"@article{RN189,\n author = {Jiang, C. and Davalos, R. V. and Bischof, J. C.},\n title = {A review of basic to clinical studies of irreversible electroporation therapy},\n journal = {IEEE Trans Biomed Eng},\n volume = {62},\n number = {1},\n pages = {4-20},\n note = {1558-2531\nJiang, Chunlan\nDavalos, Rafael V\nBischof, John C\nJournal Article\nResearch Support, Non-U.S. Gov't\nResearch Support, U.S. Gov't, Non-P.H.S.\nReview\nUnited States\n2014/11/13\nIEEE Trans Biomed Eng. 2015 Jan;62(1):4-20. doi: 10.1109/TBME.2014.2367543.},\n abstract = {The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over the past decade. As a nonthermal therapy, IRE offers several potential benefits over other focal therapies, which include 1) short treatment delivery time, 2) reduced collateral thermal injury, and 3) the ability to treat tumors adjacent to major blood vessels. These advantages have stimulated widespread interest in basic through clinical studies of IRE. For instance, many in vitro and in vivo studies now identify treatment planning protocols (IRE threshold, pulse parameters, etc.), electrode delivery (electrode design, placement, intraoperative imaging methods, etc.), injury evaluation (methods and timing), and treatment efficacy in different cancer models. Therefore, this study reviews the in vitro, translational, and clinical studies of IRE cancer therapy based on major experimental studies particularly within the past decade. 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