Principles of connectivity among morphologically defined cell types in adult neocortex. Jiang, X., Shen, S., Cadwell, C. R., Berens, P., Sinz, F., Ecker, A. S., Patel, S., & Tolias, A. S. Science, 350(6264):aac9462, November, 2015. ![Principles of connectivity among morphologically defined cell types in adult neocortex [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Since the work of Ramón y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.
@article{jiang2015,
title = {Principles of connectivity among morphologically defined cell types in adult neocortex},
volume = {350},
url = {https://www.science.org/doi/10.1126/science.aac9462},
doi = {10.1126/science.aac9462},
abstract = {Since the work of Ramón y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.},
number = {6264},
urldate = {2025-06-17},
journal = {Science},
author = {Jiang, Xiaolong and Shen, Shan and Cadwell, Cathryn R. and Berens, Philipp and Sinz, Fabian and Ecker, Alexander S. and Patel, Saumil and Tolias, Andreas S.},
month = nov,
year = {2015},
pages = {aac9462},
file = {Accepted Version:/Users/lcneuro/Zotero/storage/YAI23BXW/Jiang et al. - 2015 - Principles of connectivity among morphologically d.pdf:application/pdf},
}
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