Engineering Biocompatible Quantum Dots for Ultrasensitive, Real-Time Biological Imaging and Detection. Jiang, W., Singhal, A., Fischer, H., Mardyani, S., & Chan, W. C. W. In Ferrari, M., Desai, T., & Bhatia, S., editors, BioMEMS and Biomedical Nanotechnology: Volume III Therapeutic Micro/Nanotechnology, pages 137–156. Springer US, Boston, MA, 2007. ![Engineering Biocompatible Quantum Dots for Ultrasensitive, Real-Time Biological Imaging and Detection [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Advances in the design of optical probes have played a central role in the emergence of photon-based microscopy techniques for biological imaging and detection [1, 2, 3, 4, 5, 6]. These advances have led to the elucidation of the biological function and activity of many proteins, nucleic acids, and other molecules in living cells, tissues, and animals. Currently, the molecular architecture of greater than 70% of all optical probes consists of an “optical emitter” attached to a “targeting molecule” [4]. The targeting molecule directs the optical emitter to specific biological sites where the optical emitter can then be used to detect the activities of biomolecules. The most popular optical probes have been traditionally designed from organic-based molecules; for instance, probes for the imaging of cellular cytoskeleton are based on the conjugation of red-fluorescent molecule Texas Red to the small targeting organic molecule phalloidin (for labeling actin fibers) and green-fluorescent Alexa Fluor 488 to a recognition antibody (for labeling microtubules) [4]. Hundreds of different types of organic-based fluorescent probes are commercially available. These probes can be used in numerous applications, including the staining of DNA and proteins, detection of subtle differences in the ionic content in living cells, or detection of protein structures [4, 7, 8, 9, 10]. Due to their complex molecular structures, however, organic fluorophores often exhibit unfavorable absorption and emission properties, such as photobleaching, environmental quenching, broad and asymmetric emission spectra, and the inability to excite multiple fluorophores of more than 2–3 colors at a single wavelength [10, 11].
@incollection{jiang_engineering_2007,
address = {Boston, MA},
title = {Engineering {Biocompatible} {Quantum} {Dots} for {Ultrasensitive}, {Real}-{Time} {Biological} {Imaging} and {Detection}},
isbn = {978-0-387-25844-7},
url = {https://doi.org/10.1007/978-0-387-25844-7_8},
abstract = {Advances in the design of optical probes have played a central role in the emergence of photon-based microscopy techniques for biological imaging and detection [1, 2, 3, 4, 5, 6]. These advances have led to the elucidation of the biological function and activity of many proteins, nucleic acids, and other molecules in living cells, tissues, and animals. Currently, the molecular architecture of greater than 70\% of all optical probes consists of an “optical emitter” attached to a “targeting molecule” [4]. The targeting molecule directs the optical emitter to specific biological sites where the optical emitter can then be used to detect the activities of biomolecules. The most popular optical probes have been traditionally designed from organic-based molecules; for instance, probes for the imaging of cellular cytoskeleton are based on the conjugation of red-fluorescent molecule Texas Red to the small targeting organic molecule phalloidin (for labeling actin fibers) and green-fluorescent Alexa Fluor 488 to a recognition antibody (for labeling microtubules) [4]. Hundreds of different types of organic-based fluorescent probes are commercially available. These probes can be used in numerous applications, including the staining of DNA and proteins, detection of subtle differences in the ionic content in living cells, or detection of protein structures [4, 7, 8, 9, 10]. Due to their complex molecular structures, however, organic fluorophores often exhibit unfavorable absorption and emission properties, such as photobleaching, environmental quenching, broad and asymmetric emission spectra, and the inability to excite multiple fluorophores of more than 2–3 colors at a single wavelength [10, 11].},
language = {en},
urldate = {2021-11-06},
booktitle = {{BioMEMS} and {Biomedical} {Nanotechnology}: {Volume} {III} {Therapeutic} {Micro}/{Nanotechnology}},
publisher = {Springer US},
author = {Jiang, Wen and Singhal, Anupam and Fischer, Hans and Mardyani, Sawitri and Chan, Warren C. W.},
editor = {Ferrari, Mauro and Desai, Tejal and Bhatia, Sangeeta},
year = {2007},
doi = {10.1007/978-0-387-25844-7_8},
keywords = {CdSe Nanocrystals, Maltose Binding Protein, Optical Probe, Sentinel Lymph Node, Sentinel Lymph Node Mapping},
pages = {137--156},
file = {Springer Full Text PDF:files/2244/Jiang et al. - 2007 - Engineering Biocompatible Quantum Dots for Ultrase.pdf:application/pdf},
}
Downloads: 0
{"_id":"6egTGaLHuAJxnxX2G","bibbaseid":"jiang-singhal-fischer-mardyani-chan-engineeringbiocompatiblequantumdotsforultrasensitiverealtimebiologicalimaginganddetection-2007","author_short":["Jiang, W.","Singhal, A.","Fischer, H.","Mardyani, S.","Chan, W. C. W."],"bibdata":{"bibtype":"incollection","type":"incollection","address":"Boston, MA","title":"Engineering Biocompatible Quantum Dots for Ultrasensitive, Real-Time Biological Imaging and Detection","isbn":"978-0-387-25844-7","url":"https://doi.org/10.1007/978-0-387-25844-7_8","abstract":"Advances in the design of optical probes have played a central role in the emergence of photon-based microscopy techniques for biological imaging and detection [1, 2, 3, 4, 5, 6]. These advances have led to the elucidation of the biological function and activity of many proteins, nucleic acids, and other molecules in living cells, tissues, and animals. Currently, the molecular architecture of greater than 70% of all optical probes consists of an “optical emitter” attached to a “targeting molecule” [4]. The targeting molecule directs the optical emitter to specific biological sites where the optical emitter can then be used to detect the activities of biomolecules. The most popular optical probes have been traditionally designed from organic-based molecules; for instance, probes for the imaging of cellular cytoskeleton are based on the conjugation of red-fluorescent molecule Texas Red to the small targeting organic molecule phalloidin (for labeling actin fibers) and green-fluorescent Alexa Fluor 488 to a recognition antibody (for labeling microtubules) [4]. Hundreds of different types of organic-based fluorescent probes are commercially available. These probes can be used in numerous applications, including the staining of DNA and proteins, detection of subtle differences in the ionic content in living cells, or detection of protein structures [4, 7, 8, 9, 10]. Due to their complex molecular structures, however, organic fluorophores often exhibit unfavorable absorption and emission properties, such as photobleaching, environmental quenching, broad and asymmetric emission spectra, and the inability to excite multiple fluorophores of more than 2–3 colors at a single wavelength [10, 11].","language":"en","urldate":"2021-11-06","booktitle":"BioMEMS and Biomedical Nanotechnology: Volume III Therapeutic Micro/Nanotechnology","publisher":"Springer US","author":[{"propositions":[],"lastnames":["Jiang"],"firstnames":["Wen"],"suffixes":[]},{"propositions":[],"lastnames":["Singhal"],"firstnames":["Anupam"],"suffixes":[]},{"propositions":[],"lastnames":["Fischer"],"firstnames":["Hans"],"suffixes":[]},{"propositions":[],"lastnames":["Mardyani"],"firstnames":["Sawitri"],"suffixes":[]},{"propositions":[],"lastnames":["Chan"],"firstnames":["Warren","C.","W."],"suffixes":[]}],"editor":[{"propositions":[],"lastnames":["Ferrari"],"firstnames":["Mauro"],"suffixes":[]},{"propositions":[],"lastnames":["Desai"],"firstnames":["Tejal"],"suffixes":[]},{"propositions":[],"lastnames":["Bhatia"],"firstnames":["Sangeeta"],"suffixes":[]}],"year":"2007","doi":"10.1007/978-0-387-25844-7_8","keywords":"CdSe Nanocrystals, Maltose Binding Protein, Optical Probe, Sentinel Lymph Node, Sentinel Lymph Node Mapping","pages":"137–156","file":"Springer Full Text PDF:files/2244/Jiang et al. - 2007 - Engineering Biocompatible Quantum Dots for Ultrase.pdf:application/pdf","bibtex":"@incollection{jiang_engineering_2007,\n\taddress = {Boston, MA},\n\ttitle = {Engineering {Biocompatible} {Quantum} {Dots} for {Ultrasensitive}, {Real}-{Time} {Biological} {Imaging} and {Detection}},\n\tisbn = {978-0-387-25844-7},\n\turl = {https://doi.org/10.1007/978-0-387-25844-7_8},\n\tabstract = {Advances in the design of optical probes have played a central role in the emergence of photon-based microscopy techniques for biological imaging and detection [1, 2, 3, 4, 5, 6]. These advances have led to the elucidation of the biological function and activity of many proteins, nucleic acids, and other molecules in living cells, tissues, and animals. Currently, the molecular architecture of greater than 70\\% of all optical probes consists of an “optical emitter” attached to a “targeting molecule” [4]. The targeting molecule directs the optical emitter to specific biological sites where the optical emitter can then be used to detect the activities of biomolecules. The most popular optical probes have been traditionally designed from organic-based molecules; for instance, probes for the imaging of cellular cytoskeleton are based on the conjugation of red-fluorescent molecule Texas Red to the small targeting organic molecule phalloidin (for labeling actin fibers) and green-fluorescent Alexa Fluor 488 to a recognition antibody (for labeling microtubules) [4]. Hundreds of different types of organic-based fluorescent probes are commercially available. These probes can be used in numerous applications, including the staining of DNA and proteins, detection of subtle differences in the ionic content in living cells, or detection of protein structures [4, 7, 8, 9, 10]. Due to their complex molecular structures, however, organic fluorophores often exhibit unfavorable absorption and emission properties, such as photobleaching, environmental quenching, broad and asymmetric emission spectra, and the inability to excite multiple fluorophores of more than 2–3 colors at a single wavelength [10, 11].},\n\tlanguage = {en},\n\turldate = {2021-11-06},\n\tbooktitle = {{BioMEMS} and {Biomedical} {Nanotechnology}: {Volume} {III} {Therapeutic} {Micro}/{Nanotechnology}},\n\tpublisher = {Springer US},\n\tauthor = {Jiang, Wen and Singhal, Anupam and Fischer, Hans and Mardyani, Sawitri and Chan, Warren C. W.},\n\teditor = {Ferrari, Mauro and Desai, Tejal and Bhatia, Sangeeta},\n\tyear = {2007},\n\tdoi = {10.1007/978-0-387-25844-7_8},\n\tkeywords = {CdSe Nanocrystals, Maltose Binding Protein, Optical Probe, Sentinel Lymph Node, Sentinel Lymph Node Mapping},\n\tpages = {137--156},\n\tfile = {Springer Full Text PDF:files/2244/Jiang et al. - 2007 - Engineering Biocompatible Quantum Dots for Ultrase.pdf:application/pdf},\n}\n\n","author_short":["Jiang, W.","Singhal, A.","Fischer, H.","Mardyani, S.","Chan, W. C. W."],"editor_short":["Ferrari, M.","Desai, T.","Bhatia, S."],"key":"jiang_engineering_2007","id":"jiang_engineering_2007","bibbaseid":"jiang-singhal-fischer-mardyani-chan-engineeringbiocompatiblequantumdotsforultrasensitiverealtimebiologicalimaginganddetection-2007","role":"author","urls":{"Paper":"https://doi.org/10.1007/978-0-387-25844-7_8"},"keyword":["CdSe Nanocrystals","Maltose Binding Protein","Optical Probe","Sentinel Lymph Node","Sentinel Lymph Node Mapping"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"incollection","biburl":"https://inbslab.com//wp-content/uploads/2024/03/Chan-2024_03-14.txt","dataSources":["zb3p4i4Fd9wXynbkF","pF7M3AvRzd8m3Nc5t","BqtRhZTYdfYNLhWzp","sBWiDMMhfDHZnN93b","zkBeHFgTXc62hytzj","s3xwaPmQ7EjjEcMSb","5npqWkz6DHBZLyn3J","yc5dXnBwovT8YvCrt","nLduyq7S9B96QB8B5","JiWrSgLBTKbDLqiYi"],"keywords":["cdse nanocrystals","maltose binding protein","optical probe","sentinel lymph node","sentinel lymph node mapping"],"search_terms":["engineering","biocompatible","quantum","dots","ultrasensitive","real","time","biological","imaging","detection","jiang","singhal","fischer","mardyani","chan"],"title":"Engineering Biocompatible Quantum Dots for Ultrasensitive, Real-Time Biological Imaging and Detection","year":2007}