Effect of adenine moiety on DNA binding property of copper(ii)-terpyridine complexes. Jiang, Q., Wu, Z., Zhang, Y., Hotze, A. C G, Hannon, M. J, & Guo, Z. Dalton Transactions, 2008. ![Effect of adenine moiety on DNA binding property of copper(ii)-terpyridine complexes [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Two novel copper(ii) terpyridine complexes, [Cu(atpy)(NO3)(H2O)](NO3)[middle dot]3H2O (1) and [Cu(ttpy)(NO3)2] (2) (atpy = 4[prime or minute]-p-N9-adeninylmethylphenyl-2,2[prime or minute]:6,2[double prime]-terpyridine; ttpy = 4[prime or minute]-p-tolyl-2,2[prime or minute]:6,2[double prime]-terpyridine) have been prepared and structurally characterized by X-ray crystallography. Both complexes show a CuN3O2 coordination in a square pyramidal (4 + 1) geometry with terpyridine acting as an equatorial ligand. For complex 1, intermolecular AA base pairing interaction is observed between N6 and N1 of adjacent adenines with N6N1 of 3.027(7) A. A molecular dynamics simulation of the DNA binding of two complexes showed that the adenine moiety plays an important role in the intercalation of 1 into DNA. This is verified by UV, fluorescence, circular dichroism and flow linear dichroism studies. The promotional effect from the adenine moiety to the intracellular DNA binding of complex 1 is also confirmed by the inductively coupled plasma mass (ICP-MS) spectrometry data which showed a significant higher copper content in DNA isolated from complex 1 treated MCF-7 and HeLa cells.
@article{Jiang2008,
title = {Effect of adenine moiety on {DNA} binding property of copper(ii)-terpyridine complexes},
url = {http://dx.doi.org/10.1039/b719010g},
doi = {10.1039/b719010g},
abstract = {Two novel copper(ii) terpyridine complexes, [Cu(atpy)(NO3)(H2O)](NO3)[middle dot]3H2O (1) and [Cu(ttpy)(NO3)2] (2) (atpy = 4[prime or minute]-p-N9-adeninylmethylphenyl-2,2[prime or minute]:6,2[double prime]-terpyridine; ttpy = 4[prime or minute]-p-tolyl-2,2[prime or minute]:6,2[double prime]-terpyridine) have been prepared and structurally characterized by X-ray crystallography. Both complexes show a CuN3O2 coordination in a square pyramidal (4 + 1) geometry with terpyridine acting as an equatorial ligand. For complex 1, intermolecular AA base pairing interaction is observed between N6 and N1 of adjacent adenines with N6N1 of 3.027(7) A. A molecular dynamics simulation of the DNA binding of two complexes showed that the adenine moiety plays an important role in the intercalation of 1 into DNA. This is verified by UV, fluorescence, circular dichroism and flow linear dichroism studies. The promotional effect from the adenine moiety to the intracellular DNA binding of complex 1 is also confirmed by the inductively coupled plasma mass (ICP-MS) spectrometry data which showed a significant higher copper content in DNA isolated from complex 1 treated MCF-7 and HeLa cells.},
number = {23},
journal = {Dalton Transactions},
author = {Jiang, Qin and Wu, Zhengyi and Zhang, Yangmiao and Hotze, Anna C G and Hannon, Michael J and Guo, Zijian},
year = {2008},
keywords = {\#nosource},
pages = {3054--3060 ST -- Effect of adenine moiety on DNA bi},
}
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