Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events: a cohort study. Jick, H., Derby, L. E., García Rodríguez, L. A., Jick, S. S., & Dean, A. D. Pharmacotherapy, 13(3):212--217, June, 1993.
abstract   bibtex   
We performed a population-based study of over 100,000 users of diclofenac, naproxen, or piroxicam to identify cases of important blood, skin, central nervous system, kidney, pancreas, or pulmonary disorders caused by these drugs. In three cases a causal relation seemed likely; one of hemolytic anemia attributed to diclofenac, one of neutropenia attributed to naproxen, and one of pancreatitis attributed to piroxicam. In 13 additional cases a causal connection seemed unlikely but could not be fully ruled out. We conclude that such illnesses are uncommonly caused by the three agents studied.
@article{jick_nonsteroidal_1993,
	title = {Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events: a cohort study},
	volume = {13},
	issn = {0277-0008},
	shorttitle = {Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events},
	abstract = {We performed a population-based study of over 100,000 users of diclofenac, naproxen, or piroxicam to identify cases of important blood, skin, central nervous system, kidney, pancreas, or pulmonary disorders caused by these drugs. In three cases a causal relation seemed likely; one of hemolytic anemia attributed to diclofenac, one of neutropenia attributed to naproxen, and one of pancreatitis attributed to piroxicam. In 13 additional cases a causal connection seemed unlikely but could not be fully ruled out. We conclude that such illnesses are uncommonly caused by the three agents studied.},
	language = {eng},
	number = {3},
	journal = {Pharmacotherapy},
	author = {Jick, H. and Derby, L. E. and García Rodríguez, L. A. and Jick, S. S. and Dean, A. D.},
	month = jun,
	year = {1993},
	pmid = {8321735},
	keywords = {Adult, Aged, Aged, 80 and over, Anemia, Hemolytic, Anti-Inflammatory Agents, Non-Steroidal, Cohort Studies, Diclofenac, Female, Humans, Male, Naproxen, Neutropenia, Pancreatitis, Piroxicam, Thrombocytopenia},
	pages = {212--217}
}

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