S.cerevisiae Complex Function Prediction with Modular Multi-Relational Framework. Jimenez, B. G., Ledezma, A., & Sanchis., A. In García-Pedrajas, N., Herrera, F., Fyfe, C., Benítez, J. M., & Ali, M., editors, Trends in Applied Intelligent Systems. Proceedings of the 23rd International Conference on Industrial, Engineering & Other Applications of Applied Intelligent Systems (IEA-AIE 10)., volume 6098, of Lecture Notes in Artificial Intelligence, pages 82-91, June, 2010. Springer. abstract bibtex Gene functions is an essential knowledge for understanding how metabolism works and designing treatments for solving malfunctions. The Modular Multi-Relational Framework (MMRF) is able to predict gene group functions. Since genes working together, it is focused on group functions rather than isolated gene functions. The approach of MMRF is flexible in several aspects, such as the kind of groups, the integration of different data sources, the organism and the knowledge representation. Besides, this framework takes advantages of the intrinsic relational structure of biological data, giving an easily biological interpretable and unique relational decision tree predicting N functions at once. This research work presents a group function prediction of S.cerevisiae (i.e.Yeast) genes grouped by protein complexes using MMRF. The results show that the predictions are restricted by the shortage of examples per class. Also, they assert that the knowledge representation is very determinant to exploit the available relational information richness, and therefore, to improve both the quantitative results and their biological interpretability.
@INPROCEEDINGS{Garcia_et.al._iea-aie10,
author = {Beatriz García Jimenez and Agapito Ledezma and Araceli Sanchis.},
title = {S.cerevisiae Complex Function Prediction with Modular Multi-Relational
Framework.},
booktitle = {Trends in Applied Intelligent Systems. Proceedings of the 23rd International
Conference on Industrial, Engineering \& Other Applications of Applied
Intelligent Systems (IEA-AIE 10).},
year = {2010},
editor = {Nicol\'{a}s Garc\'{\i}a-Pedrajas and Francisco Herrera and Colin
Fyfe and Jos\'{e} Manuel Ben\'{\i}tez and Moonis Ali},
volume = {6098},
series = {Lecture Notes in Artificial Intelligence},
pages = {82-91},
month = {June},
publisher = {Springer},
abstract = {Gene functions is an essential knowledge for understanding how metabolism
works and designing treatments for solving malfunctions. The Modular
Multi-Relational Framework (MMRF) is able to predict gene group functions.
Since genes working together, it is focused on group functions rather
than isolated gene functions. The approach of MMRF is flexible in
several aspects, such as the kind of groups, the integration of different
data sources, the organism and the knowledge representation. Besides,
this framework takes advantages of the intrinsic relational structure
of biological data, giving an easily biological interpretable and
unique relational decision tree predicting N functions at once. This
research work presents a group function prediction of S.cerevisiae
(i.e.Yeast) genes grouped by protein complexes using MMRF. The results
show that the predictions are restricted by the shortage of examples
per class. Also, they assert that the knowledge representation is
very determinant to exploit the available relational information
richness, and therefore, to improve both the quantitative results
and their biological interpretability.},
isbn = {978-3-642-13032-8},
location = {Cordoba, Spain}
}
Downloads: 0
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Proceedings of the 23rd International\n\tConference on Industrial, Engineering \\& Other Applications of Applied\n\tIntelligent Systems (IEA-AIE 10).},\n year = {2010},\n editor = {Nicol\\'{a}s Garc\\'{\\i}a-Pedrajas and Francisco Herrera and Colin\n\tFyfe and Jos\\'{e} Manuel Ben\\'{\\i}tez and Moonis Ali},\n volume = {6098},\n series = {Lecture Notes in Artificial Intelligence},\n pages = {82-91},\n month = {June},\n publisher = {Springer},\n abstract = {Gene functions is an essential knowledge for understanding how metabolism\n\tworks and designing treatments for solving malfunctions. The Modular\n\tMulti-Relational Framework (MMRF) is able to predict gene group functions.\n\tSince genes working together, it is focused on group functions rather\n\tthan isolated gene functions. The approach of MMRF is flexible in\n\tseveral aspects, such as the kind of groups, the integration of different\n\tdata sources, the organism and the knowledge representation. 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