Late-onset cytomegalovirus reactivation in critically ill renal transplant patients. Jochimsen, F., Westhoff, T., Engelmann, E., Schafer, J., Offermann, G., & Zidek, W. Transplantation, 76(2):430--432, July, 2003. doi abstract bibtex BACKGROUND: Cytomegalovirus (CMV) reactivation occurs frequently in the first months after renal transplantation. However, reports concerning long-term kidney transplant recipients are rare and have always pertained to symptomatic CMV disease. METHODS: We report four cases of late-onset asymptomatic CMV reactivation in critically ill renal transplant patients who suffered from severe bacterial infections and in whom CMV antigenemia was observed. RESULTS AND CONCLUSION: CMV reactivation in these patients might indicate an additional disturbance in the patients' immune defenses at the time of critical illness, possibly even necessitating a temporary reduction in immunosuppressive therapy. Prospective, controlled trials are needed to define the role of CMV antigenemia in critically ill patients, including the role of antiviral therapy for asymptomatic reactivations.
@article{jochimsen_late-onset_2003,
title = {Late-onset cytomegalovirus reactivation in critically ill renal transplant patients.},
volume = {76},
issn = {0041-1337 0041-1337},
doi = {10.1097/01.TP.0000075091.80548.5B},
abstract = {BACKGROUND: Cytomegalovirus (CMV) reactivation occurs frequently in the first months after renal transplantation. However, reports concerning long-term kidney transplant recipients are rare and have always pertained to symptomatic CMV disease. METHODS: We report four cases of late-onset asymptomatic CMV reactivation in critically ill renal transplant patients who suffered from severe bacterial infections and in whom CMV antigenemia was observed. RESULTS AND CONCLUSION: CMV reactivation in these patients might indicate an additional disturbance in the patients' immune defenses at the time of critical illness, possibly even necessitating a temporary reduction in immunosuppressive therapy. Prospective, controlled trials are needed to define the role of CMV antigenemia in critically ill patients, including the role of antiviral therapy for asymptomatic reactivations.},
language = {eng},
number = {2},
journal = {Transplantation},
author = {Jochimsen, Friederike and Westhoff, Timm and Engelmann, Elisabeth and Schafer, Jurgen-Heiner and Offermann, Gerd and Zidek, Walter},
month = jul,
year = {2003},
pmid = {12883206},
keywords = {*Kidney Transplantation, Acute Disease, Aged, Antiviral Agents/administration \& dosage, Bacterial Infections/*complications, Critical Illness, Cytomegalovirus Infections/*complications/drug therapy, Female, Ganciclovir/administration \& dosage, Humans, Middle Aged, Neutrophils/virology, Phosphoproteins/analysis, Recurrence, Superinfection/complications, Time Factors, Viral Matrix Proteins/analysis},
pages = {430--432}
}
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However, reports concerning long-term kidney transplant recipients are rare and have always pertained to symptomatic CMV disease. METHODS: We report four cases of late-onset asymptomatic CMV reactivation in critically ill renal transplant patients who suffered from severe bacterial infections and in whom CMV antigenemia was observed. RESULTS AND CONCLUSION: CMV reactivation in these patients might indicate an additional disturbance in the patients' immune defenses at the time of critical illness, possibly even necessitating a temporary reduction in immunosuppressive therapy. Prospective, controlled trials are needed to define the role of CMV antigenemia in critically ill patients, including the role of antiviral therapy for asymptomatic reactivations.","language":"eng","number":"2","journal":"Transplantation","author":[{"propositions":[],"lastnames":["Jochimsen"],"firstnames":["Friederike"],"suffixes":[]},{"propositions":[],"lastnames":["Westhoff"],"firstnames":["Timm"],"suffixes":[]},{"propositions":[],"lastnames":["Engelmann"],"firstnames":["Elisabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Schafer"],"firstnames":["Jurgen-Heiner"],"suffixes":[]},{"propositions":[],"lastnames":["Offermann"],"firstnames":["Gerd"],"suffixes":[]},{"propositions":[],"lastnames":["Zidek"],"firstnames":["Walter"],"suffixes":[]}],"month":"July","year":"2003","pmid":"12883206","keywords":"*Kidney Transplantation, Acute Disease, Aged, Antiviral Agents/administration & dosage, Bacterial Infections/*complications, Critical Illness, Cytomegalovirus Infections/*complications/drug therapy, Female, Ganciclovir/administration & dosage, Humans, Middle Aged, Neutrophils/virology, Phosphoproteins/analysis, Recurrence, Superinfection/complications, Time Factors, Viral Matrix Proteins/analysis","pages":"430--432","bibtex":"@article{jochimsen_late-onset_2003,\n\ttitle = {Late-onset cytomegalovirus reactivation in critically ill renal transplant patients.},\n\tvolume = {76},\n\tissn = {0041-1337 0041-1337},\n\tdoi = {10.1097/01.TP.0000075091.80548.5B},\n\tabstract = {BACKGROUND: Cytomegalovirus (CMV) reactivation occurs frequently in the first months after renal transplantation. However, reports concerning long-term kidney transplant recipients are rare and have always pertained to symptomatic CMV disease. METHODS: We report four cases of late-onset asymptomatic CMV reactivation in critically ill renal transplant patients who suffered from severe bacterial infections and in whom CMV antigenemia was observed. RESULTS AND CONCLUSION: CMV reactivation in these patients might indicate an additional disturbance in the patients' immune defenses at the time of critical illness, possibly even necessitating a temporary reduction in immunosuppressive therapy. 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