Effect of breast-feeding on seroresponse of infants to oral poliovirus vaccination. John, T J, Devarajan, L V, Luther, L, & Vijayarathnam, P Pediatrics, 57(1):47–53, January, 1976. ![Effect of breast-feeding on seroresponse of infants to oral poliovirus vaccination [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Three hundred Indian infants between 6 and 51 weeks of age were divided into six groups and given three doses of trivalent oral polio vaccine (OPV) of known adequate potency. One group was on unrestricted breast-feeding with mandatory breast-feed during the interval between 30 minutes before and 15 minutes after each dose of OPV. In four groups of infants breast-feeding was withheld for three, four, five, and six hours both before and after each dose of OPV. The sixth group was bottle-fed. Samples of blood were collected from all infants before vaccination and from 227 infants further samples were collected four weeks after the first and/or third doses of OPV. Antibody responses to poliovirus types 1, 2, and 3 were determined following one dose and three doses of OPV, and the rates of response were found to be approximately equal in all groups of breast-fed infants irrespective of their feeding schedules, as well as in bottle-fed infants. Thus breast-feeding is shown to have no inhibitory effect on antibody response of infants beyond the newborn period to OPV.
@article{john_effect_1976,
title = {Effect of breast-feeding on seroresponse of infants to oral poliovirus vaccination},
volume = {57},
issn = {0031-4005},
url = {http://www.ncbi.nlm.nih.gov/pubmed/174056},
abstract = {Three hundred Indian infants between 6 and 51 weeks of age were divided into six groups and given three doses of trivalent oral polio vaccine (OPV) of known adequate potency. One group was on unrestricted breast-feeding with mandatory breast-feed during the interval between 30 minutes before and 15 minutes after each dose of OPV. In four groups of infants breast-feeding was withheld for three, four, five, and six hours both before and after each dose of OPV. The sixth group was bottle-fed. Samples of blood were collected from all infants before vaccination and from 227 infants further samples were collected four weeks after the first and/or third doses of OPV. Antibody responses to poliovirus types 1, 2, and 3 were determined following one dose and three doses of OPV, and the rates of response were found to be approximately equal in all groups of breast-fed infants irrespective of their feeding schedules, as well as in bottle-fed infants. Thus breast-feeding is shown to have no inhibitory effect on antibody response of infants beyond the newborn period to OPV.},
number = {1},
urldate = {2011-06-08},
journal = {Pediatrics},
author = {John, T J and Devarajan, L V and Luther, L and Vijayarathnam, P},
month = jan,
year = {1976},
pmid = {174056},
keywords = {Antibodies, Viral, Antibody Formation, Bottle Feeding, Breast Feeding, Humans, Immunity, Immunization, India, Infant, Poliovirus, Poliovirus Vaccine, Oral},
pages = {47--53},
}
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