Accumulation of α-hexabromocyclododecane (α-HBCDD) in tissues of fast- and slow-growing broilers (Gallus domesticus). Jondreville, C., Cariou, R., Méda, B., Dominguez-Romero, E., Omer, E., Dervilly-Pinel, G., Le Bizec, B., Travel, A., & Baéza, E. 178:424–431.
Accumulation of α-hexabromocyclododecane (α-HBCDD) in tissues of fast- and slow-growing broilers (Gallus domesticus) [link]Paper  doi  abstract   bibtex   
The aim of the current study was to describe the fate of ingested a-hexabromocyclododecane (a-HBCDD) in fast-growing (FG) and slow-growing (SG) broilers, through an exposure to a dietary concentration of 50 ng a-HBCDD gÀ1 feed during 42 and 84 days, respectively. Depuration parameters were assessed in SG broilers successively exposed during 42 days and depurated during 42 days. At market age, SG broilers had ingested 42% more feed than FG broilers, while their body weight gain per g of feed ingested was 34% lower. No isomerization of a- to b- or g-HBCDD forms occurred, while OH-HBCDD was identified as a product of a-HBCDD metabolism. Irrespective of the strain, abdominal fat displayed the highest a-HBCDD concentration on a lipid weight basis, followed leg muscles and then breast muscle, liver and plasma. The accumulation ratios of a-HBCDD were slightly higher in SG (6.7, 2.1, 2.6 and 9.9 in leg muscles, breast muscle, liver and abdominal fat, respectively) than in FG broilers (5.2, 2.2, 1.1 and 8.4, respectively). The elimination half-lives in SG broilers were 20, 12 and 19 d in leg muscles, breast muscle and abdominal fat, respectively, to which dilution through growth contributed for around 50%. The overall assimilation efficiency of a-HBCDD was estimated at 58 and 50% in FG and SG broilers, respectively, while 22 and 17% of a-HBCDD ingested were estimated to be eliminated in excreta as metabolites.
@article{jondreville_accumulation_2017,
	title = {Accumulation of α-hexabromocyclododecane (α-{HBCDD}) in tissues of fast- and slow-growing broilers (Gallus domesticus)},
	volume = {178},
	issn = {00456535},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0045653517304277},
	doi = {10.1016/j.chemosphere.2017.03.064},
	abstract = {The aim of the current study was to describe the fate of ingested a-hexabromocyclododecane (a-{HBCDD}) in fast-growing ({FG}) and slow-growing ({SG}) broilers, through an exposure to a dietary concentration of 50 ng a-{HBCDD} {gÀ}1 feed during 42 and 84 days, respectively. Depuration parameters were assessed in {SG} broilers successively exposed during 42 days and depurated during 42 days. At market age, {SG} broilers had ingested 42\% more feed than {FG} broilers, while their body weight gain per g of feed ingested was 34\% lower. No isomerization of a- to b- or g-{HBCDD} forms occurred, while {OH}-{HBCDD} was identified as a product of a-{HBCDD} metabolism. Irrespective of the strain, abdominal fat displayed the highest a-{HBCDD} concentration on a lipid weight basis, followed leg muscles and then breast muscle, liver and plasma. The accumulation ratios of a-{HBCDD} were slightly higher in {SG} (6.7, 2.1, 2.6 and 9.9 in leg muscles, breast muscle, liver and abdominal fat, respectively) than in {FG} broilers (5.2, 2.2, 1.1 and 8.4, respectively). The elimination half-lives in {SG} broilers were 20, 12 and 19 d in leg muscles, breast muscle and abdominal fat, respectively, to which dilution through growth contributed for around 50\%. The overall assimilation efficiency of a-{HBCDD} was estimated at 58 and 50\% in {FG} and {SG} broilers, respectively, while 22 and 17\% of a-{HBCDD} ingested were estimated to be eliminated in excreta as metabolites.},
	pages = {424--431},
	journaltitle = {Chemosphere},
	author = {Jondreville, Catherine and Cariou, Ronan and Méda, Bertrand and Dominguez-Romero, Elena and Omer, Elsa and Dervilly-Pinel, Gaud and Le Bizec, Bruno and Travel, Angélique and Baéza, Elisabeth},
	urldate = {2019-03-29},
	date = {2017-07},
	langid = {english},
	file = {Jondreville et al. - 2017 - Accumulation of α-hexabromocyclododecane (α-HBCDD).pdf:C\:\\Users\\ygu\\Documents\\PCPOR066_YGU\\YGU\\Zotero\\storage\\7ESXNDVV\\Jondreville et al. - 2017 - Accumulation of α-hexabromocyclododecane (α-HBCDD).pdf:application/pdf}
}
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