Do puerperal psychotic episodes identify a more familial subtype of bipolar disorder? Results of a family history study. Jones, I. & Craddock, N. Psychiatric Genetics, 12(3):177–180, September, 2002. doi abstract bibtex Bipolar women have a marked vulnerability to puerperal psychosis, an episode of mania or psychosis following childbirth. We have conducted a family history study to examine the question of whether a vulnerability to puerperal episodes of illness is a marker for a more familial form of bipolar disorder. A consecutive series of 103 bipolar disorder probands were recruited in a lithium clinic and given a semi-structured interview, including a detailed family history. For the 52 female probands, information was also obtained about the relationship of episodes to childbirth. The morbid risk of affective disorder in first-degree relatives of bipolar women who had suffered an episode of mania, hypomania or schizoaffective mania with onset within 6 weeks of childbirth was significantly higher than that in relatives of parous bipolar women with no episodes in relation to childbirth (P = 0.0077). Despite relatively small numbers, this study provides evidence to support the hypothesis that puerperal episodes identify a more familial subtype of bipolar disorder. © 2002 Lippincott Williams & Wilkins.
@article{jones_puerperal_2002,
title = {Do puerperal psychotic episodes identify a more familial subtype of bipolar disorder? {Results} of a family history study},
volume = {12},
doi = {10.1097/00041444-200209000-00011},
abstract = {Bipolar women have a marked vulnerability to puerperal psychosis, an episode of mania or psychosis following childbirth. We have conducted a family history study to examine the question of whether a vulnerability to puerperal episodes of illness is a marker for a more familial form of bipolar disorder. A consecutive series of 103 bipolar disorder probands were recruited in a lithium clinic and given a semi-structured interview, including a detailed family history. For the 52 female probands, information was also obtained about the relationship of episodes to childbirth. The morbid risk of affective disorder in first-degree relatives of bipolar women who had suffered an episode of mania, hypomania or schizoaffective mania with onset within 6 weeks of childbirth was significantly higher than that in relatives of parous bipolar women with no episodes in relation to childbirth (P = 0.0077). Despite relatively small numbers, this study provides evidence to support the hypothesis that puerperal episodes identify a more familial subtype of bipolar disorder. © 2002 Lippincott Williams \& Wilkins.},
number = {3},
urldate = {2021-09-07},
journal = {Psychiatric Genetics},
author = {Jones, Ian and Craddock, Nick},
month = sep,
year = {2002},
keywords = {Affective disorder, Bipolar, Family study, Genetics, Perinatal, Postnatal, Puerperal psychosis},
pages = {177--180},
}
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