Immunoglobulin M in health and diseases: how far have we come and what next?. Jones, K., Savulescu, A. F., Brombacher, F., & Hadebe, S. Frontiers in Immunology, 11:595535, Frontiers, oct, 2020. ![Immunoglobulin M in health and diseases: how far have we come and what next? [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex B lymphocytes are important in secreting antibodies that protect against invading pathogens such as viruses, bacteria, parasites, and also in mediating pathogenesis of allergic diseases and autoimmunity. B lymphocytes develop in the bone marrow and contain heavy and light chains, which upon ligation form an immunoglobulin M (IgM) B cell receptor (BCR) expressed on the surface of naïve immature B cells. Naïve B cells expressing either IgM or IgD isotypes are thought to play interchangeable functions in antibody responses to T cell-dependent and T cell-independent antigens. IgM short-lived plasma cells (SLPCs) and antigen-specific IgM memory B cells (MBCs-M) are critical in the first few days of infection, as well as long-term memory induced by vaccination, respectively. At mucosal surfaces, IgM is thought to play a critical part in promoting mucosal tolerance and shaping microbiota together with IgA. In this review, we explore how IgM structure and BCR signaling shapes B cell development, self and non-self-antigen-specific antibody responses, responses to infectious (such as viruses, parasites, and fungal) and non-communicable diseases (such as autoimmunity and allergic asthma). We also explore how metabolism could influence other B cell functions such as mucosal tolerance and class switching. Finally, we discuss some of the outstanding critical research questions in both experimental and clinical settings targeting IgM.
@article{Jones2020,
abstract = {B lymphocytes are important in secreting antibodies that protect against invading pathogens such as viruses, bacteria, parasites, and also in mediating pathogenesis of allergic diseases and autoimmunity. B lymphocytes develop in the bone marrow and contain heavy and light chains, which upon ligation form an immunoglobulin M (IgM) B cell receptor (BCR) expressed on the surface of na{\"{i}}ve immature B cells. Na{\"{i}}ve B cells expressing either IgM or IgD isotypes are thought to play interchangeable functions in antibody responses to T cell-dependent and T cell-independent antigens. IgM short-lived plasma cells (SLPCs) and antigen-specific IgM memory B cells (MBCs-M) are critical in the first few days of infection, as well as long-term memory induced by vaccination, respectively. At mucosal surfaces, IgM is thought to play a critical part in promoting mucosal tolerance and shaping microbiota together with IgA. In this review, we explore how IgM structure and BCR signaling shapes B cell development, self and non-self-antigen-specific antibody responses, responses to infectious (such as viruses, parasites, and fungal) and non-communicable diseases (such as autoimmunity and allergic asthma). We also explore how metabolism could influence other B cell functions such as mucosal tolerance and class switching. Finally, we discuss some of the outstanding critical research questions in both experimental and clinical settings targeting IgM.},
author = {Jones, Katelyn and Savulescu, Anca F. and Brombacher, Frank and Hadebe, Sabelo},
doi = {10.3389/fimmu.2020.595535},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Jones et al. - 2020 - Immunoglobulin M in health and diseases how far have we come and what next.pdf:pdf},
issn = {1664-3224},
journal = {Frontiers in Immunology},
keywords = {B cell development,OA,OA{\_}PMC,fund{\_}ack,immunoglobulin M (IgM),long-lived plasma cell (LLPC),memory B cell (MBC),review,short-lived plasma cell (SLPC)},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,review},
month = {oct},
pages = {595535},
pmid = {33193450},
publisher = {Frontiers},
title = {{Immunoglobulin M in health and diseases: how far have we come and what next?}},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2020.595535/full},
volume = {11},
year = {2020}
}
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