Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts. Jung, A., Frotscher, R., & Staat, M. In Owen, R., de Borst, R., Reese, J., & Pearce, C., editors, 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), pages 859–869, Glasgow, 2018. International Center for Numerical Methods in Engineering (CIMNE) Barcelona, Spain. ZSCC: NoCitationData[s0]
Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts [pdf]Paper  abstract   bibtex   
The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stressin the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.

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