@article{ kafkafi_see_2003,
  title = {{SEE} locomotor behavior test discriminates C57BL/6J and {DBA}/2J mouse inbred strains across laboratories and protocol conditions.},
  volume = {117},
  issn = {0735-7044},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/12802875},
  abstract = {Conventional tests of behavioral phenotyping frequently have difficulties differentiating certain genotypes and replicating these differences across laboratories and protocol conditions. This study explores the hypothesis that automated tests can be designed to quantify ethologically relevant behavior patterns that more readily characterize heritable and replicable phenotypes. It used {SEE} (Strategy for the Exploration of Exploration) to phenotype the locomotor behavior of the C57BL/6 and {DBA}/2 mouse inbred strains across 3 laboratories. The 2 genotypes differed in 15 different measures of behavior, none of which had a significant genotype-laboratory interaction. Within the same laboratory, most of these differences were replicated in additional experiments despite the test photoperiod phase being changed and saline being injected. Results suggest that well-designed tests may considerably enhance replicability across laboratories.},
  number = {3},
  journal = {Behavioral neuroscience},
  author = {Kafkafi, Neri and Lipkind, Dina and Benjamini, Yoav and Mayo, Cheryl L and Elmer, Gregory I and Golani, Ilan},
  month = {June},
  year = {2003},
  pmid = {12802875},
  keywords = {Animals, Exploratory Behavior, Exploratory Behavior: physiology, Genotype, Inbred C57BL, Inbred C57BL: physiology, Inbred {DBA}, Inbred {DBA}: physiology, Laboratories, Laboratories: standards, Laboratories: statistics \& numerical data, Male, Mice, Motor Activity, Motor Activity: physiology, Research Design, Research Design: standards, Research Design: statistics \& numerical data, Species Specificity},
  pages = {464–77}
}

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This study explores the hypothesis that automated tests can be designed to quantify ethologically relevant behavior patterns that more readily characterize heritable and replicable phenotypes. It used {SEE} (Strategy for the Exploration of Exploration) to phenotype the locomotor behavior of the C57BL/6 and {DBA}/2 mouse inbred strains across 3 laboratories. The 2 genotypes differed in 15 different measures of behavior, none of which had a significant genotype-laboratory interaction. Within the same laboratory, most of these differences were replicated in additional experiments despite the test photoperiod phase being changed and saline being injected. Results suggest that well-designed tests may considerably enhance replicability across laboratories.},\n number = {3},\n journal = {Behavioral neuroscience},\n author = {Kafkafi, Neri and Lipkind, Dina and Benjamini, Yoav and Mayo, Cheryl L and Elmer, Gregory I and Golani, Ilan},\n month = {June},\n year = {2003},\n pmid = {12802875},\n keywords = {Animals, Exploratory Behavior, Exploratory Behavior: physiology, Genotype, Inbred C57BL, Inbred C57BL: physiology, Inbred {DBA}, Inbred {DBA}: physiology, Laboratories, Laboratories: standards, Laboratories: statistics \\& numerical data, Male, Mice, Motor Activity, Motor Activity: physiology, Research Design, Research Design: standards, Research Design: statistics \\& numerical data, Species Specificity},\n pages = {464–77}\n}","author_short":["Kafkafi, N.","Lipkind, D.","Benjamini, Y.","Mayo","L, C.","Elmer","I, G.","Golani, I."],"author":["Kafkafi, Neri","Lipkind, Dina","Benjamini, Yoav","Mayo","L, Cheryl","Elmer","I, Gregory","Golani, Ilan"],"abstract":"Conventional tests of behavioral phenotyping frequently have difficulties differentiating certain genotypes and replicating these differences across laboratories and protocol conditions. This study explores the hypothesis that automated tests can be designed to quantify ethologically relevant behavior patterns that more readily characterize heritable and replicable phenotypes. It used SEE (Strategy for the Exploration of Exploration) to phenotype the locomotor behavior of the C57BL/6 and DBA/2 mouse inbred strains across 3 laboratories. The 2 genotypes differed in 15 different measures of behavior, none of which had a significant genotype-laboratory interaction. Within the same laboratory, most of these differences were replicated in additional experiments despite the test photoperiod phase being changed and saline being injected. Results suggest that well-designed tests may considerably enhance replicability across laboratories."},"bibtype":"article","biburl":"https://api.zotero.org/users/1299170/collections/3KFSEJFF/items?key=o62IKmNhu30JYmECcfJ7pnUa&format=bibtex&limit=100","creationDate":"2014-08-27T17:59:17.078Z","downloads":0,"keywords":["animals","exploratory behavior","exploratory behavior: physiology","genotype","inbred c57bl","inbred c57bl: physiology","inbred dba","inbred dba: physiology","laboratories","laboratories: standards","laboratories: statistics \\& numerical data","male","mice","motor activity","motor activity: physiology","research design","research design: standards","research design: statistics \\& numerical data","species specificity"],"search_terms":["see","locomotor","behavior","test","discriminates","c57bl","dba","mouse","inbred","strains","laboratories","protocol","conditions","kafkafi","lipkind","benjamini","mayo","l","elmer","i","golani"],"title":"SEE locomotor behavior test discriminates C57BL/6J and DBA/2J mouse inbred strains across laboratories and protocol conditions.","year":2003,"dataSources":["xtb3Ei2zXJcbQ7KZF"]}