Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands. Kamps, A., Runhaar, J., de Ridder, M. A. J., de Wilde, M., van der Lei, J., Zhang, W., Prieto-Alhambra, D., Englund, M., de Schepper, E. I. T., & Bierma-Zeinstra, S. M. A. Osteoarthritis and Cartilage, December, 2022. ![Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Objective To determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA). Design A cohort study was conducted using the Integrated Primary Care Information database, containing electronic health records of 2.5 million patients from the Netherlands. Adults at risk for OA were included. Diagnosis of knee or hip OA (=exposure) and 58 long-term comorbidities (=outcome) were defined by diagnostic codes following the International Classification of Primary Care coding system. Time between the start of follow-up and incident diagnosis of OA was defined as unexposed, and between diagnosis of OA and the end of follow-up as exposed. Age and sex adjusted hazard ratios (HRs) comparing comorbidity rates in exposed and unexposed patient time were estimated with 99.9% confidence intervals (CI). Results The study population consisted of 1,890,712 patients. For 30 of the 58 studied comorbidities, exposure to knee OA showed a HR larger than 1. Largest positive associations (HR with (99.9% CIs)) were found for obesity 2.55 (2.29–2.84) and fibromyalgia 2.06 (1.53–2.77). For two conditions a HR \textless 1 was found, other comorbidities showed no association with exposure to knee OA. For 26 comorbidities, exposure to hip OA showed a HR larger than 1. The largest were found for polymyalgia rheumatica 1.81 (1.41–2.32) and fibromyalgia 1.70 (1.10–2.63). All other comorbidities showed no associations with hip OA. Conclusion This study showed that many comorbidities were diagnosed more often in patients with knee or hip OA. This suggests that the management of OA should consider the risk of other long-term-conditions.
@article{kamps_occurrence_2022,
title = {Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the {Netherlands}},
issn = {1063-4584},
shorttitle = {Occurrence of comorbidity following osteoarthritis diagnosis},
url = {https://www.sciencedirect.com/science/article/pii/S1063458422009578},
doi = {10.1016/j.joca.2022.12.003},
abstract = {Objective
To determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA).
Design
A cohort study was conducted using the Integrated Primary Care Information database, containing electronic health records of 2.5 million patients from the Netherlands. Adults at risk for OA were included. Diagnosis of knee or hip OA (=exposure) and 58 long-term comorbidities (=outcome) were defined by diagnostic codes following the International Classification of Primary Care coding system. Time between the start of follow-up and incident diagnosis of OA was defined as unexposed, and between diagnosis of OA and the end of follow-up as exposed. Age and sex adjusted hazard ratios (HRs) comparing comorbidity rates in exposed and unexposed patient time were estimated with 99.9\% confidence intervals (CI).
Results
The study population consisted of 1,890,712 patients. For 30 of the 58 studied comorbidities, exposure to knee OA showed a HR larger than 1. Largest positive associations (HR with (99.9\% CIs)) were found for obesity 2.55 (2.29–2.84) and fibromyalgia 2.06 (1.53–2.77). For two conditions a HR {\textless} 1 was found, other comorbidities showed no association with exposure to knee OA. For 26 comorbidities, exposure to hip OA showed a HR larger than 1. The largest were found for polymyalgia rheumatica 1.81 (1.41–2.32) and fibromyalgia 1.70 (1.10–2.63). All other comorbidities showed no associations with hip OA.
Conclusion
This study showed that many comorbidities were diagnosed more often in patients with knee or hip OA. This suggests that the management of OA should consider the risk of other long-term-conditions.},
language = {en},
urldate = {2023-02-02},
journal = {Osteoarthritis and Cartilage},
author = {Kamps, A. and Runhaar, J. and de Ridder, M. A. J. and de Wilde, M. and van der Lei, J. and Zhang, W. and Prieto-Alhambra, D. and Englund, M. and de Schepper, E. I. T. and Bierma-Zeinstra, S. M. A.},
month = dec,
year = {2022},
keywords = {Comorbidity, Electronic health record (EHR), Osteoarthritis, Primary care},
}
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{"_id":"vrcrfHcrcptFcJBye","bibbaseid":"kamps-runhaar-deridder-dewilde-vanderlei-zhang-prietoalhambra-englund-etal-occurrenceofcomorbidityfollowingosteoarthritisdiagnosisacohortstudyinthenetherlands-2022","author_short":["Kamps, A.","Runhaar, J.","de Ridder, M. A. J.","de Wilde, M.","van der Lei, J.","Zhang, W.","Prieto-Alhambra, D.","Englund, M.","de Schepper, E. I. T.","Bierma-Zeinstra, S. M. A."],"bibdata":{"bibtype":"article","type":"article","title":"Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands","issn":"1063-4584","shorttitle":"Occurrence of comorbidity following osteoarthritis diagnosis","url":"https://www.sciencedirect.com/science/article/pii/S1063458422009578","doi":"10.1016/j.joca.2022.12.003","abstract":"Objective To determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA). Design A cohort study was conducted using the Integrated Primary Care Information database, containing electronic health records of 2.5 million patients from the Netherlands. Adults at risk for OA were included. Diagnosis of knee or hip OA (=exposure) and 58 long-term comorbidities (=outcome) were defined by diagnostic codes following the International Classification of Primary Care coding system. Time between the start of follow-up and incident diagnosis of OA was defined as unexposed, and between diagnosis of OA and the end of follow-up as exposed. Age and sex adjusted hazard ratios (HRs) comparing comorbidity rates in exposed and unexposed patient time were estimated with 99.9% confidence intervals (CI). Results The study population consisted of 1,890,712 patients. For 30 of the 58 studied comorbidities, exposure to knee OA showed a HR larger than 1. Largest positive associations (HR with (99.9% CIs)) were found for obesity 2.55 (2.29–2.84) and fibromyalgia 2.06 (1.53–2.77). For two conditions a HR \\textless 1 was found, other comorbidities showed no association with exposure to knee OA. For 26 comorbidities, exposure to hip OA showed a HR larger than 1. The largest were found for polymyalgia rheumatica 1.81 (1.41–2.32) and fibromyalgia 1.70 (1.10–2.63). All other comorbidities showed no associations with hip OA. Conclusion This study showed that many comorbidities were diagnosed more often in patients with knee or hip OA. This suggests that the management of OA should consider the risk of other long-term-conditions.","language":"en","urldate":"2023-02-02","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Kamps"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Runhaar"],"firstnames":["J."],"suffixes":[]},{"propositions":["de"],"lastnames":["Ridder"],"firstnames":["M.","A.","J."],"suffixes":[]},{"propositions":["de"],"lastnames":["Wilde"],"firstnames":["M."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Lei"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["W."],"suffixes":[]},{"propositions":[],"lastnames":["Prieto-Alhambra"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["M."],"suffixes":[]},{"propositions":["de"],"lastnames":["Schepper"],"firstnames":["E.","I.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Bierma-Zeinstra"],"firstnames":["S.","M.","A."],"suffixes":[]}],"month":"December","year":"2022","keywords":"Comorbidity, Electronic health record (EHR), Osteoarthritis, Primary care","bibtex":"@article{kamps_occurrence_2022,\n\ttitle = {Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the {Netherlands}},\n\tissn = {1063-4584},\n\tshorttitle = {Occurrence of comorbidity following osteoarthritis diagnosis},\n\turl = {https://www.sciencedirect.com/science/article/pii/S1063458422009578},\n\tdoi = {10.1016/j.joca.2022.12.003},\n\tabstract = {Objective\nTo determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA).\nDesign\nA cohort study was conducted using the Integrated Primary Care Information database, containing electronic health records of 2.5 million patients from the Netherlands. Adults at risk for OA were included. Diagnosis of knee or hip OA (=exposure) and 58 long-term comorbidities (=outcome) were defined by diagnostic codes following the International Classification of Primary Care coding system. Time between the start of follow-up and incident diagnosis of OA was defined as unexposed, and between diagnosis of OA and the end of follow-up as exposed. Age and sex adjusted hazard ratios (HRs) comparing comorbidity rates in exposed and unexposed patient time were estimated with 99.9\\% confidence intervals (CI).\nResults\nThe study population consisted of 1,890,712 patients. For 30 of the 58 studied comorbidities, exposure to knee OA showed a HR larger than 1. Largest positive associations (HR with (99.9\\% CIs)) were found for obesity 2.55 (2.29–2.84) and fibromyalgia 2.06 (1.53–2.77). For two conditions a HR {\\textless} 1 was found, other comorbidities showed no association with exposure to knee OA. For 26 comorbidities, exposure to hip OA showed a HR larger than 1. The largest were found for polymyalgia rheumatica 1.81 (1.41–2.32) and fibromyalgia 1.70 (1.10–2.63). All other comorbidities showed no associations with hip OA.\nConclusion\nThis study showed that many comorbidities were diagnosed more often in patients with knee or hip OA. This suggests that the management of OA should consider the risk of other long-term-conditions.},\n\tlanguage = {en},\n\turldate = {2023-02-02},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Kamps, A. and Runhaar, J. and de Ridder, M. A. J. and de Wilde, M. and van der Lei, J. and Zhang, W. and Prieto-Alhambra, D. and Englund, M. and de Schepper, E. I. T. and Bierma-Zeinstra, S. M. A.},\n\tmonth = dec,\n\tyear = {2022},\n\tkeywords = {Comorbidity, Electronic health record (EHR), Osteoarthritis, Primary care},\n}\n\n","author_short":["Kamps, A.","Runhaar, J.","de Ridder, M. A. 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