Donor-recipient race mismatch and graft survival after pediatric heart transplantation. Kanter, K., Berg, A., Mahle, W., Vincent, R., Kilgo, P., Kogon, B., & Kirshbom, P. Ann Thorac Surg, 87(1):204–209, January, 2009. ![Donor-recipient race mismatch and graft survival after pediatric heart transplantation. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BACKGROUND: Black recipient race has been shown to predict poorer graft survival after pediatric heart transplantation. We analyzed our single-center experience comparing graft survival by race and the impact of donor-recipient race mismatch. METHODS: One hundred sixty-nine consecutive primary pediatric heart transplant patients were analyzed by donor and recipient race (white recipient, 99; black recipient, 60; other, 10). The groups were similar in preoperative characteristics. There were fewer donor-recipient race matches in blacks compared with whites (10 versus 71; p \textless 0.0001). RESULTS: Although 30-day and 6-month graft survival was similar for black and white recipients (93.9% and 85.8% versus 93.3% and 83.3%, respectively), overall actuarial graft survival was significantly lower in blacks (p \textless 0.019). Blacks tended to have a higher incidence of positive retrospective crossmatch (n = 26, 43%) than whites (n = 29, 29%), but this was not statistically significant (p = 0.053). The median graft survival for black recipients was 5.5 years compared with 11.6 years for whites. Donor-recipient race mismatch predicted poorer graft survival (5-year graft survival 48.9% versus 72.3%; p = 0.0032). The median graft survival for donor-recipient race-matched patients was more than twice that for mismatched patients (11.6 years versus 4.4 years). Cox proportional hazard analysis showed that donor-recipient race mismatch neutralized the effect of race on graft survival. CONCLUSIONS: Graft survival after pediatric heart transplantation is inferior for black recipients compared with white recipients. These differences may be explained by a high incidence of donor-recipient race mismatch, which also predicts poorer outcome for all racial groups with pediatric heart transplantation. These data may have implications for future donor allocation schemes.
@article{kanter_donor-recipient_2009,
title = {Donor-recipient race mismatch and graft survival after pediatric heart transplantation.},
volume = {87},
url = {https://www.ncbi.nlm.nih.gov/pubmed/19101298},
doi = {10.1016/j.athoracsur.2008.09.074},
abstract = {BACKGROUND: Black recipient race has been shown to predict poorer graft survival after pediatric heart transplantation. We analyzed our single-center experience comparing graft survival by race and the impact of donor-recipient race mismatch. METHODS: One hundred sixty-nine consecutive primary pediatric heart transplant patients were analyzed by donor and recipient race (white recipient, 99; black recipient, 60; other, 10). The groups were similar in preoperative characteristics. There were fewer donor-recipient race matches in blacks compared with whites (10 versus 71; p {\textless} 0.0001). RESULTS: Although 30-day and 6-month graft survival was similar for black and white recipients (93.9\% and 85.8\% versus 93.3\% and 83.3\%, respectively), overall actuarial graft survival was significantly lower in blacks (p {\textless} 0.019). Blacks tended to have a higher incidence of positive retrospective crossmatch (n = 26, 43\%) than whites (n = 29, 29\%), but this was not statistically significant (p = 0.053). The median graft survival for black recipients was 5.5 years compared with 11.6 years for whites. Donor-recipient race mismatch predicted poorer graft survival (5-year graft survival 48.9\% versus 72.3\%; p = 0.0032). The median graft survival for donor-recipient race-matched patients was more than twice that for mismatched patients (11.6 years versus 4.4 years). Cox proportional hazard analysis showed that donor-recipient race mismatch neutralized the effect of race on graft survival. CONCLUSIONS: Graft survival after pediatric heart transplantation is inferior for black recipients compared with white recipients. These differences may be explained by a high incidence of donor-recipient race mismatch, which also predicts poorer outcome for all racial groups with pediatric heart transplantation. These data may have implications for future donor allocation schemes.},
language = {eng},
number = {1},
journal = {Ann Thorac Surg},
author = {Kanter, KR and Berg, AM and Mahle, WT and Vincent, RN and Kilgo, PD and Kogon, BE and Kirshbom, PM},
month = jan,
year = {2009},
keywords = {Treatment Outcome},
pages = {204--209}
}
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{"_id":"pfmNvxY6PtRzFNKnq","bibbaseid":"kanter-berg-mahle-vincent-kilgo-kogon-kirshbom-donorrecipientracemismatchandgraftsurvivalafterpediatrichearttransplantation-2009","downloads":0,"creationDate":"2019-02-06T19:58:23.243Z","title":"Donor-recipient race mismatch and graft survival after pediatric heart transplantation.","author_short":["Kanter, K.","Berg, A.","Mahle, W.","Vincent, R.","Kilgo, P.","Kogon, B.","Kirshbom, P."],"year":2009,"bibtype":"article","biburl":"https://api.zotero.org/users/5494130/collections/RBFGKWC2/items?key=bPKCKbQJ3ej3KoeUhSSlR8nj&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Donor-recipient race mismatch and graft survival after pediatric heart transplantation.","volume":"87","url":"https://www.ncbi.nlm.nih.gov/pubmed/19101298","doi":"10.1016/j.athoracsur.2008.09.074","abstract":"BACKGROUND: Black recipient race has been shown to predict poorer graft survival after pediatric heart transplantation. We analyzed our single-center experience comparing graft survival by race and the impact of donor-recipient race mismatch. METHODS: One hundred sixty-nine consecutive primary pediatric heart transplant patients were analyzed by donor and recipient race (white recipient, 99; black recipient, 60; other, 10). The groups were similar in preoperative characteristics. There were fewer donor-recipient race matches in blacks compared with whites (10 versus 71; p \\textless 0.0001). RESULTS: Although 30-day and 6-month graft survival was similar for black and white recipients (93.9% and 85.8% versus 93.3% and 83.3%, respectively), overall actuarial graft survival was significantly lower in blacks (p \\textless 0.019). Blacks tended to have a higher incidence of positive retrospective crossmatch (n = 26, 43%) than whites (n = 29, 29%), but this was not statistically significant (p = 0.053). The median graft survival for black recipients was 5.5 years compared with 11.6 years for whites. Donor-recipient race mismatch predicted poorer graft survival (5-year graft survival 48.9% versus 72.3%; p = 0.0032). The median graft survival for donor-recipient race-matched patients was more than twice that for mismatched patients (11.6 years versus 4.4 years). Cox proportional hazard analysis showed that donor-recipient race mismatch neutralized the effect of race on graft survival. CONCLUSIONS: Graft survival after pediatric heart transplantation is inferior for black recipients compared with white recipients. These differences may be explained by a high incidence of donor-recipient race mismatch, which also predicts poorer outcome for all racial groups with pediatric heart transplantation. These data may have implications for future donor allocation schemes.","language":"eng","number":"1","journal":"Ann Thorac Surg","author":[{"propositions":[],"lastnames":["Kanter"],"firstnames":["KR"],"suffixes":[]},{"propositions":[],"lastnames":["Berg"],"firstnames":["AM"],"suffixes":[]},{"propositions":[],"lastnames":["Mahle"],"firstnames":["WT"],"suffixes":[]},{"propositions":[],"lastnames":["Vincent"],"firstnames":["RN"],"suffixes":[]},{"propositions":[],"lastnames":["Kilgo"],"firstnames":["PD"],"suffixes":[]},{"propositions":[],"lastnames":["Kogon"],"firstnames":["BE"],"suffixes":[]},{"propositions":[],"lastnames":["Kirshbom"],"firstnames":["PM"],"suffixes":[]}],"month":"January","year":"2009","keywords":"Treatment Outcome","pages":"204–209","bibtex":"@article{kanter_donor-recipient_2009,\n\ttitle = {Donor-recipient race mismatch and graft survival after pediatric heart transplantation.},\n\tvolume = {87},\n\turl = {https://www.ncbi.nlm.nih.gov/pubmed/19101298},\n\tdoi = {10.1016/j.athoracsur.2008.09.074},\n\tabstract = {BACKGROUND: Black recipient race has been shown to predict poorer graft survival after pediatric heart transplantation. We analyzed our single-center experience comparing graft survival by race and the impact of donor-recipient race mismatch. METHODS: One hundred sixty-nine consecutive primary pediatric heart transplant patients were analyzed by donor and recipient race (white recipient, 99; black recipient, 60; other, 10). The groups were similar in preoperative characteristics. There were fewer donor-recipient race matches in blacks compared with whites (10 versus 71; p {\\textless} 0.0001). RESULTS: Although 30-day and 6-month graft survival was similar for black and white recipients (93.9\\% and 85.8\\% versus 93.3\\% and 83.3\\%, respectively), overall actuarial graft survival was significantly lower in blacks (p {\\textless} 0.019). Blacks tended to have a higher incidence of positive retrospective crossmatch (n = 26, 43\\%) than whites (n = 29, 29\\%), but this was not statistically significant (p = 0.053). The median graft survival for black recipients was 5.5 years compared with 11.6 years for whites. Donor-recipient race mismatch predicted poorer graft survival (5-year graft survival 48.9\\% versus 72.3\\%; p = 0.0032). The median graft survival for donor-recipient race-matched patients was more than twice that for mismatched patients (11.6 years versus 4.4 years). Cox proportional hazard analysis showed that donor-recipient race mismatch neutralized the effect of race on graft survival. CONCLUSIONS: Graft survival after pediatric heart transplantation is inferior for black recipients compared with white recipients. These differences may be explained by a high incidence of donor-recipient race mismatch, which also predicts poorer outcome for all racial groups with pediatric heart transplantation. These data may have implications for future donor allocation schemes.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Ann Thorac Surg},\n\tauthor = {Kanter, KR and Berg, AM and Mahle, WT and Vincent, RN and Kilgo, PD and Kogon, BE and Kirshbom, PM},\n\tmonth = jan,\n\tyear = {2009},\n\tkeywords = {Treatment Outcome},\n\tpages = {204--209}\n}\n\n","author_short":["Kanter, K.","Berg, A.","Mahle, W.","Vincent, R.","Kilgo, P.","Kogon, B.","Kirshbom, P."],"key":"kanter_donor-recipient_2009","id":"kanter_donor-recipient_2009","bibbaseid":"kanter-berg-mahle-vincent-kilgo-kogon-kirshbom-donorrecipientracemismatchandgraftsurvivalafterpediatrichearttransplantation-2009","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/19101298"},"keyword":["Treatment Outcome"],"downloads":0},"search_terms":["donor","recipient","race","mismatch","graft","survival","pediatric","heart","transplantation","kanter","berg","mahle","vincent","kilgo","kogon","kirshbom"],"keywords":["treatment outcome"],"authorIDs":[],"dataSources":["KyTuPiocfts86K47z"]}