Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance. Kapikian, A Z, Wyatt, R G, Levine, M M, Yolken, R H, VanKirk, D H, Dolin, R, Greenberg, H B, & Chanock, R M The Journal of Infectious Diseases, 147(1):95–106, January, 1983. ![Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Four of 18 volunteers challenged orally with human rotavirus strain D (subgroup 2, serotype Wa) developed a diarrheal illness two to four days after inoculation. Viral shedding was detected in five of the 18 volunteers, whereas 12 (67%) developed serologic evidence of infection. Two volunteers who developed diarrheal illness after the initial inoculation were given the same inoculum 19 months later; neither developed diarrhea, although one developed constitutional and gastrointestinal symptoms. The presence of preinoculation serum immunofluorescent antibody to rotavirus strain D or high levels of neutralizing antibody to Wa or reassortant DS-1 human rotavirus correlated with resistance to diarrheal illness. Although prechallenge serum antibody correlated with resistance to diarrhea and/or shedding of rotavirus, the relationship of preexisting local neutralizing activity in intestinal fluid was less clear-cut.
@article{kapikian_oral_1983,
title = {Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance},
volume = {147},
issn = {0022-1899},
shorttitle = {Oral administration of human rotavirus to volunteers},
url = {http://www.ncbi.nlm.nih.gov/pubmed/6296243},
abstract = {Four of 18 volunteers challenged orally with human rotavirus strain D (subgroup 2, serotype Wa) developed a diarrheal illness two to four days after inoculation. Viral shedding was detected in five of the 18 volunteers, whereas 12 (67\%) developed serologic evidence of infection. Two volunteers who developed diarrheal illness after the initial inoculation were given the same inoculum 19 months later; neither developed diarrhea, although one developed constitutional and gastrointestinal symptoms. The presence of preinoculation serum immunofluorescent antibody to rotavirus strain D or high levels of neutralizing antibody to Wa or reassortant DS-1 human rotavirus correlated with resistance to diarrheal illness. Although prechallenge serum antibody correlated with resistance to diarrhea and/or shedding of rotavirus, the relationship of preexisting local neutralizing activity in intestinal fluid was less clear-cut.},
number = {1},
urldate = {2011-06-15},
journal = {The Journal of Infectious Diseases},
author = {Kapikian, A Z and Wyatt, R G and Levine, M M and Yolken, R H and VanKirk, D H and Dolin, R and Greenberg, H B and Chanock, R M},
month = jan,
year = {1983},
pmid = {6296243},
pages = {95--106},
}
Downloads: 0
{"_id":"ycPgsZP64ups2fXfu","bibbaseid":"kapikian-wyatt-levine-yolken-vankirk-dolin-greenberg-chanock-oraladministrationofhumanrotavirustovolunteersinductionofillnessandcorrelatesofresistance-1983","author_short":["Kapikian, A Z","Wyatt, R G","Levine, M M","Yolken, R H","VanKirk, D H","Dolin, R","Greenberg, H B","Chanock, R M"],"bibdata":{"bibtype":"article","type":"article","title":"Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance","volume":"147","issn":"0022-1899","shorttitle":"Oral administration of human rotavirus to volunteers","url":"http://www.ncbi.nlm.nih.gov/pubmed/6296243","abstract":"Four of 18 volunteers challenged orally with human rotavirus strain D (subgroup 2, serotype Wa) developed a diarrheal illness two to four days after inoculation. Viral shedding was detected in five of the 18 volunteers, whereas 12 (67%) developed serologic evidence of infection. Two volunteers who developed diarrheal illness after the initial inoculation were given the same inoculum 19 months later; neither developed diarrhea, although one developed constitutional and gastrointestinal symptoms. The presence of preinoculation serum immunofluorescent antibody to rotavirus strain D or high levels of neutralizing antibody to Wa or reassortant DS-1 human rotavirus correlated with resistance to diarrheal illness. Although prechallenge serum antibody correlated with resistance to diarrhea and/or shedding of rotavirus, the relationship of preexisting local neutralizing activity in intestinal fluid was less clear-cut.","number":"1","urldate":"2011-06-15","journal":"The Journal of Infectious Diseases","author":[{"propositions":[],"lastnames":["Kapikian"],"firstnames":["A","Z"],"suffixes":[]},{"propositions":[],"lastnames":["Wyatt"],"firstnames":["R","G"],"suffixes":[]},{"propositions":[],"lastnames":["Levine"],"firstnames":["M","M"],"suffixes":[]},{"propositions":[],"lastnames":["Yolken"],"firstnames":["R","H"],"suffixes":[]},{"propositions":[],"lastnames":["VanKirk"],"firstnames":["D","H"],"suffixes":[]},{"propositions":[],"lastnames":["Dolin"],"firstnames":["R"],"suffixes":[]},{"propositions":[],"lastnames":["Greenberg"],"firstnames":["H","B"],"suffixes":[]},{"propositions":[],"lastnames":["Chanock"],"firstnames":["R","M"],"suffixes":[]}],"month":"January","year":"1983","pmid":"6296243","pages":"95–106","bibtex":"@article{kapikian_oral_1983,\n\ttitle = {Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance},\n\tvolume = {147},\n\tissn = {0022-1899},\n\tshorttitle = {Oral administration of human rotavirus to volunteers},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/6296243},\n\tabstract = {Four of 18 volunteers challenged orally with human rotavirus strain D (subgroup 2, serotype Wa) developed a diarrheal illness two to four days after inoculation. Viral shedding was detected in five of the 18 volunteers, whereas 12 (67\\%) developed serologic evidence of infection. Two volunteers who developed diarrheal illness after the initial inoculation were given the same inoculum 19 months later; neither developed diarrhea, although one developed constitutional and gastrointestinal symptoms. The presence of preinoculation serum immunofluorescent antibody to rotavirus strain D or high levels of neutralizing antibody to Wa or reassortant DS-1 human rotavirus correlated with resistance to diarrheal illness. Although prechallenge serum antibody correlated with resistance to diarrhea and/or shedding of rotavirus, the relationship of preexisting local neutralizing activity in intestinal fluid was less clear-cut.},\n\tnumber = {1},\n\turldate = {2011-06-15},\n\tjournal = {The Journal of Infectious Diseases},\n\tauthor = {Kapikian, A Z and Wyatt, R G and Levine, M M and Yolken, R H and VanKirk, D H and Dolin, R and Greenberg, H B and Chanock, R M},\n\tmonth = jan,\n\tyear = {1983},\n\tpmid = {6296243},\n\tpages = {95--106},\n}\n\n","author_short":["Kapikian, A Z","Wyatt, R G","Levine, M M","Yolken, R H","VanKirk, D H","Dolin, R","Greenberg, H B","Chanock, R M"],"key":"kapikian_oral_1983","id":"kapikian_oral_1983","bibbaseid":"kapikian-wyatt-levine-yolken-vankirk-dolin-greenberg-chanock-oraladministrationofhumanrotavirustovolunteersinductionofillnessandcorrelatesofresistance-1983","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/6296243"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":[],"search_terms":["oral","administration","human","rotavirus","volunteers","induction","illness","correlates","resistance","kapikian","wyatt","levine","yolken","vankirk","dolin","greenberg","chanock"],"title":"Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance","year":1983}