@article{kavoussi_impact_2025,
	title = {Impact of follicle size before luteal progesterone supplementation on clinical outcomes of modified natural cycle single frozen embryo transfer},
	volume = {6},
	issn = {26663341},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2666334124001442},
	doi = {10.1016/j.xfre.2024.12.001},
	abstract = {Objective: To determine whether follicle size at midcycle transvaginal sonography imaging before luteal progesterone supplementation predicts modified natural cycle single frozen embryo transfer (mNC-SFET) outcomes. Design: Retrospective chart review. Subjects: Frozen embryo transfer charts were reviewed. After inclusion and exclusion criteria were applied, data were abstracted from cases of mNC-SFET (n ¼ 115). Exposure: For group A, lead follicle measuring {\textless}16 mm on day of trigger or peak þovulation predictor kit (n ¼ 50), and for group B, lead follicle measuring R16 mm on day of trigger or peak þovulation predictor kit (n ¼ 65). Main Outcome Measures: Follicle size analyzed as possible predictor of primary outcome ongoing pregnancy rate (OPR) as well as secondary outcomes implantation rate (IR), clinical pregnancy rate (CPR), and spontaneous abortion (SAB) rate via bivariate associations and multivariate logistic regression analyses.
Results: Bivariate analyses showed no differences between groups in OPR (A, 48.0\%, 24/50, and B, 44.6 \%, 29/65), IR (A, 64.0\%, 32/50, and B, 61.5\%, 40/65), CPR (A, 58.0\%, 29/50, and B, 52.3\%, 34/65), and SAB rates (A, 25.0\%, 8/32, and B, 27.5\%, 11/40). Multivariate analysis to investigate potential confounding between lead follicle size and outcomes of interest showed no difference in the primary and secondary outcomes. Furthermore, multivariate analyses using lead follicle size as a continuous variable showed no difference in outcomes.
Conclusion: In normo-ovulatory women undergoing mNC-SFET with natural endometrial preparation with human chorionic gonadotropin trigger or luteinizing hormone surge to time frozen embryo transfer, lead follicle size before luteal phase supplementation does not impact clinical outcomes such as IR, CPR, SAB rate, or OPR. (F S RepÒ 2025;6:47–51. Ó2024 by American Society for Reproductive Medicine.)},
	language = {en},
	number = {1},
	urldate = {2025-11-11},
	journal = {F\&S Reports},
	author = {Kavoussi, Shahryar K. and Chen, Shu-Hung and Farzaneh, Negar and Farahi, Arya and Mehrabani-Farsi, Romtin and Aston, Kenneth I. and Chen, Justin and Kavoussi, Parviz K.},
	month = mar,
	year = {2025},
	pages = {47--51},
}

{"_id":"Z9isrEQQKH56CZjQ9","bibbaseid":"kavoussi-chen-farzaneh-farahi-mehrabanifarsi-aston-chen-kavoussi-impactoffolliclesizebeforelutealprogesteronesupplementationonclinicaloutcomesofmodifiednaturalcyclesinglefrozenembryotransfer-2025","author_short":["Kavoussi, S. K.","Chen, S.","Farzaneh, N.","Farahi, A.","Mehrabani-Farsi, R.","Aston, K. I.","Chen, J.","Kavoussi, P. K."],"bibdata":{"bibtype":"article","type":"article","title":"Impact of follicle size before luteal progesterone supplementation on clinical outcomes of modified natural cycle single frozen embryo transfer","volume":"6","issn":"26663341","url":"https://linkinghub.elsevier.com/retrieve/pii/S2666334124001442","doi":"10.1016/j.xfre.2024.12.001","abstract":"Objective: To determine whether follicle size at midcycle transvaginal sonography imaging before luteal progesterone supplementation predicts modified natural cycle single frozen embryo transfer (mNC-SFET) outcomes. Design: Retrospective chart review. Subjects: Frozen embryo transfer charts were reviewed. After inclusion and exclusion criteria were applied, data were abstracted from cases of mNC-SFET (n ¼ 115). Exposure: For group A, lead follicle measuring \\textless16 mm on day of trigger or peak þovulation predictor kit (n ¼ 50), and for group B, lead follicle measuring R16 mm on day of trigger or peak þovulation predictor kit (n ¼ 65). Main Outcome Measures: Follicle size analyzed as possible predictor of primary outcome ongoing pregnancy rate (OPR) as well as secondary outcomes implantation rate (IR), clinical pregnancy rate (CPR), and spontaneous abortion (SAB) rate via bivariate associations and multivariate logistic regression analyses. Results: Bivariate analyses showed no differences between groups in OPR (A, 48.0%, 24/50, and B, 44.6 %, 29/65), IR (A, 64.0%, 32/50, and B, 61.5%, 40/65), CPR (A, 58.0%, 29/50, and B, 52.3%, 34/65), and SAB rates (A, 25.0%, 8/32, and B, 27.5%, 11/40). Multivariate analysis to investigate potential confounding between lead follicle size and outcomes of interest showed no difference in the primary and secondary outcomes. Furthermore, multivariate analyses using lead follicle size as a continuous variable showed no difference in outcomes. Conclusion: In normo-ovulatory women undergoing mNC-SFET with natural endometrial preparation with human chorionic gonadotropin trigger or luteinizing hormone surge to time frozen embryo transfer, lead follicle size before luteal phase supplementation does not impact clinical outcomes such as IR, CPR, SAB rate, or OPR. (F S RepÒ 2025;6:47–51. Ó2024 by American Society for Reproductive Medicine.)","language":"en","number":"1","urldate":"2025-11-11","journal":"F&S Reports","author":[{"propositions":[],"lastnames":["Kavoussi"],"firstnames":["Shahryar","K."],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Shu-Hung"],"suffixes":[]},{"propositions":[],"lastnames":["Farzaneh"],"firstnames":["Negar"],"suffixes":[]},{"propositions":[],"lastnames":["Farahi"],"firstnames":["Arya"],"suffixes":[]},{"propositions":[],"lastnames":["Mehrabani-Farsi"],"firstnames":["Romtin"],"suffixes":[]},{"propositions":[],"lastnames":["Aston"],"firstnames":["Kenneth","I."],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Justin"],"suffixes":[]},{"propositions":[],"lastnames":["Kavoussi"],"firstnames":["Parviz","K."],"suffixes":[]}],"month":"March","year":"2025","pages":"47–51","bibtex":"@article{kavoussi_impact_2025,\n\ttitle = {Impact of follicle size before luteal progesterone supplementation on clinical outcomes of modified natural cycle single frozen embryo transfer},\n\tvolume = {6},\n\tissn = {26663341},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2666334124001442},\n\tdoi = {10.1016/j.xfre.2024.12.001},\n\tabstract = {Objective: To determine whether follicle size at midcycle transvaginal sonography imaging before luteal progesterone supplementation predicts modified natural cycle single frozen embryo transfer (mNC-SFET) outcomes. Design: Retrospective chart review. Subjects: Frozen embryo transfer charts were reviewed. After inclusion and exclusion criteria were applied, data were abstracted from cases of mNC-SFET (n ¼ 115). Exposure: For group A, lead follicle measuring {\\textless}16 mm on day of trigger or peak þovulation predictor kit (n ¼ 50), and for group B, lead follicle measuring R16 mm on day of trigger or peak þovulation predictor kit (n ¼ 65). Main Outcome Measures: Follicle size analyzed as possible predictor of primary outcome ongoing pregnancy rate (OPR) as well as secondary outcomes implantation rate (IR), clinical pregnancy rate (CPR), and spontaneous abortion (SAB) rate via bivariate associations and multivariate logistic regression analyses.\nResults: Bivariate analyses showed no differences between groups in OPR (A, 48.0\\%, 24/50, and B, 44.6 \\%, 29/65), IR (A, 64.0\\%, 32/50, and B, 61.5\\%, 40/65), CPR (A, 58.0\\%, 29/50, and B, 52.3\\%, 34/65), and SAB rates (A, 25.0\\%, 8/32, and B, 27.5\\%, 11/40). Multivariate analysis to investigate potential confounding between lead follicle size and outcomes of interest showed no difference in the primary and secondary outcomes. Furthermore, multivariate analyses using lead follicle size as a continuous variable showed no difference in outcomes.\nConclusion: In normo-ovulatory women undergoing mNC-SFET with natural endometrial preparation with human chorionic gonadotropin trigger or luteinizing hormone surge to time frozen embryo transfer, lead follicle size before luteal phase supplementation does not impact clinical outcomes such as IR, CPR, SAB rate, or OPR. (F S RepÒ 2025;6:47–51. Ó2024 by American Society for Reproductive Medicine.)},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2025-11-11},\n\tjournal = {F\\&S Reports},\n\tauthor = {Kavoussi, Shahryar K. and Chen, Shu-Hung and Farzaneh, Negar and Farahi, Arya and Mehrabani-Farsi, Romtin and Aston, Kenneth I. and Chen, Justin and Kavoussi, Parviz K.},\n\tmonth = mar,\n\tyear = {2025},\n\tpages = {47--51},\n}\n\n\n\n\n\n\n\n\n\n\n\n","author_short":["Kavoussi, S. K.","Chen, S.","Farzaneh, N.","Farahi, A.","Mehrabani-Farsi, R.","Aston, K. I.","Chen, J.","Kavoussi, P. K."],"key":"kavoussi_impact_2025","id":"kavoussi_impact_2025","bibbaseid":"kavoussi-chen-farzaneh-farahi-mehrabanifarsi-aston-chen-kavoussi-impactoffolliclesizebeforelutealprogesteronesupplementationonclinicaloutcomesofmodifiednaturalcyclesinglefrozenembryotransfer-2025","role":"author","urls":{"Paper":"https://linkinghub.elsevier.com/retrieve/pii/S2666334124001442"},"metadata":{"authorlinks":{}},"downloads":0},"bibtype":"article","biburl":"https://bibbase.org/zotero-group/pratikmhatre/5933976","dataSources":["yJr5AAtJ5Sz3Q4WT4"],"keywords":[],"search_terms":["impact","follicle","size","before","luteal","progesterone","supplementation","clinical","outcomes","modified","natural","cycle","single","frozen","embryo","transfer","kavoussi","chen","farzaneh","farahi","mehrabani-farsi","aston","chen","kavoussi"],"title":"Impact of follicle size before luteal progesterone supplementation on clinical outcomes of modified natural cycle single frozen embryo transfer","year":2025}