Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner. Keeton, R., Richardson, S. I., Moyo-Gwete, T., Hermanus, T., Tincho, M. B., Benede, N., Manamela, N. P., Baguma, R., Makhado, Z., Ngomti, A., Motlou, T., Mennen, M., Chinhoyi, L., Skelem, S., Maboreke, H., Doolabh, D., Iranzadeh, A., Otter, A. D., Brooks, T., Noursadeghi, M., Moon, J. C., Grifoni, A., Weiskopf, D., Sette, A., Blackburn, J., Hsiao, N., Williamson, C., Riou, C., Goga, A., Garrett, N., Bekker, L., Gray, G., Ntusi, N. A., Moore, P. L., & Burgers, W. A. Cell Host & Microbe, 29(11):1611–1619.e5, Cell Press, nov, 2021. ![Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The Johnson and Johnson Ad26.COV2.S single-dose vaccine represents an attractive option for coronavirus disease 2019 (COVID-19) vaccination in countries with limited resources. We examined the effect of prior infection with different SARS-CoV-2 variants on Ad26.COV2.S immunogenicity. We compared participants who were SARS-CoV-2 naive with those either infected with the ancestral D614G virus or infected in the second wave when Beta predominated. Prior infection significantly boosts spike-binding antibodies, antibody-dependent cellular cytotoxicity, and neutralizing antibodies against D614G, Beta, and Delta; however, neutralization cross-reactivity varied by wave. Robust CD4 and CD8 T cell responses are induced after vaccination, regardless of prior infection. T cell recognition of variants is largely preserved, apart from some reduction in CD8 recognition of Delta. Thus, Ad26.COV2.S vaccination after infection could result in enhanced protection against COVID-19. The impact of the infecting variant on neutralization breadth after vaccination has implications for the design of second-generation vaccines based on variants of concern.
@article{Keeton2021a,
abstract = {The Johnson and Johnson Ad26.COV2.S single-dose vaccine represents an attractive option for coronavirus disease 2019 (COVID-19) vaccination in countries with limited resources. We examined the effect of prior infection with different SARS-CoV-2 variants on Ad26.COV2.S immunogenicity. We compared participants who were SARS-CoV-2 naive with those either infected with the ancestral D614G virus or infected in the second wave when Beta predominated. Prior infection significantly boosts spike-binding antibodies, antibody-dependent cellular cytotoxicity, and neutralizing antibodies against D614G, Beta, and Delta; however, neutralization cross-reactivity varied by wave. Robust CD4 and CD8 T cell responses are induced after vaccination, regardless of prior infection. T cell recognition of variants is largely preserved, apart from some reduction in CD8 recognition of Delta. Thus, Ad26.COV2.S vaccination after infection could result in enhanced protection against COVID-19. The impact of the infecting variant on neutralization breadth after vaccination has implications for the design of second-generation vaccines based on variants of concern.},
author = {Keeton, Roanne and Richardson, Simone I. and Moyo-Gwete, Thandeka and Hermanus, Tandile and Tincho, Marius B. and Benede, Ntombi and Manamela, Nelia P. and Baguma, Richard and Makhado, Zanele and Ngomti, Amkele and Motlou, Thopisang and Mennen, Mathilda and Chinhoyi, Lionel and Skelem, Sango and Maboreke, Hazel and Doolabh, Deelan and Iranzadeh, Arash and Otter, Ashley D. and Brooks, Tim and Noursadeghi, Mahdad and Moon, James C. and Grifoni, Alba and Weiskopf, Daniela and Sette, Alessandro and Blackburn, Jonathan and Hsiao, Nei-Yuan and Williamson, Carolyn and Riou, Catherine and Goga, Ameena and Garrett, Nigel and Bekker, Linda-Gail and Gray, Glenda and Ntusi, Ntobeko A.B. and Moore, Penny L. and Burgers, Wendy A.},
doi = {10.1016/j.chom.2021.10.003},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Keeton et al. - 2021 - Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner.pdf:pdf},
issn = {19313128},
journal = {Cell Host {\&} Microbe},
keywords = {OA,OA{\_}PMC,fund{\_}ack,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {nov},
number = {11},
pages = {1611--1619.e5},
pmid = {34688376},
publisher = {Cell Press},
title = {{Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner}},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1931312821004650},
volume = {29},
year = {2021}
}
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