T cell responses to SARS-CoV-2 spike cross-recognize Omicron. Keeton, R., Tincho, M. B, Ngomti, A., Baguma, R., Benede, N., Suzuki, A., Khan, K., Cele, S., Bernstein, M., Karim, F., Madzorera, S. V, Moyo-Gwete, T., Mennen, M., Skelem, S., Adriaanse, M., Mutithu, D., Aremu, O., Stek, C., du Bruyn, E., Van Der Mescht, M. A, de Beer, Z., de Villiers, T. R, Bodenstein, A., van den Berg, G., Mendes, A., Strydom, A., Venter, M., Giandhari, J., Naidoo, Y., Pillay, S., Tegally, H., Grifoni, A., Weiskopf, D., Sette, A., Wilkinson, R. J, de Oliveira, T., Bekker, L., Gray, G., Ueckermann, V., Rossouw, T., Boswell, M. T, Bihman, J., Moore, P. L, Sigal, A., Ntusi, N. A B, Burgers, W. A, & Riou, C. Nature, 603:488–492, Nature Publishing Group, jan, 2022.
T cell responses to SARS-CoV-2 spike cross-recognize Omicron [link]Paper  doi  abstract   bibtex   
The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations1,2 that contribute to escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. We assessed the ability of T cells to react with Omicron spike in participants who were vaccinated with Ad26.CoV2.S, BNT162b2, or unvaccinated convalescent COVID-19 patients (n=70). We found that 70-80% of the CD4+ and CD8+ T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar to Beta and Delta variants, despite Omicron harboring considerably more mutations. In Omicron-infected hospitalized patients (n=19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n=49). Thus, despite Omicron's extensive mutations and reduced susceptibility to neutralizing antibodies, the majority of T cell responses, induced by vaccination or infection, cross-recognize the variant. It remains to be determined whether well-preserved T cell immunity to Omicron contributes to protection from severe COVID-19, and is linked to early clinical observations from South Africa and elsewhere9–12.
@article{Keeton2022,
abstract = {The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations1,2 that contribute to escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. We assessed the ability of T cells to react with Omicron spike in participants who were vaccinated with Ad26.CoV2.S, BNT162b2, or unvaccinated convalescent COVID-19 patients (n=70). We found that 70-80{\%} of the CD4+ and CD8+ T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar to Beta and Delta variants, despite Omicron harboring considerably more mutations. In Omicron-infected hospitalized patients (n=19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n=49). Thus, despite Omicron's extensive mutations and reduced susceptibility to neutralizing antibodies, the majority of T cell responses, induced by vaccination or infection, cross-recognize the variant. It remains to be determined whether well-preserved T cell immunity to Omicron contributes to protection from severe COVID-19, and is linked to early clinical observations from South Africa and elsewhere9–12.},
author = {Keeton, Roanne and Tincho, Marius B and Ngomti, Amkele and Baguma, Richard and Benede, Ntombi and Suzuki, Akiko and Khan, Khadija and Cele, Sandile and Bernstein, Mallory and Karim, Farina and Madzorera, Sharon V and Moyo-Gwete, Thandeka and Mennen, Mathilda and Skelem, Sango and Adriaanse, Marguerite and Mutithu, Daniel and Aremu, Olukayode and Stek, Cari and du Bruyn, Elsa and {Van Der Mescht}, Mieke A and de Beer, Zelda and de Villiers, Talita R and Bodenstein, Annie and van den Berg, Gretha and Mendes, Adriano and Strydom, Amy and Venter, Marietjie and Giandhari, Jennifer and Naidoo, Yeshnee and Pillay, Sureshnee and Tegally, Houriiyah and Grifoni, Alba and Weiskopf, Daniela and Sette, Alessandro and Wilkinson, Robert J and de Oliveira, Tulio and Bekker, Linda-Gail and Gray, Glenda and Ueckermann, Veronica and Rossouw, Theresa and Boswell, Michael T and Bihman, Jinal and Moore, Penny L and Sigal, Alex and Ntusi, Ntobeko A B and Burgers, Wendy A and Riou, Catherine},
doi = {10.1038/s41586-022-04460-3},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Keeton et al. - 2022 - T cell responses to SARS-CoV-2 spike cross-recognize Omicron.pdf:pdf},
issn = {1476-4687},
journal = {Nature},
keywords = {2,CoV,Lymphocyte activation,OA,SARS,Viral infection,fund{\_}ack,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {jan},
pages = {488--492},
pmid = {35102311},
publisher = {Nature Publishing Group},
title = {{T cell responses to SARS-CoV-2 spike cross-recognize Omicron}},
url = {https://www.nature.com/articles/s41586-022-04460-3},
volume = {603},
year = {2022}
}
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