Toward the blood-borne miRNome of human diseases. Keller, A., Leidinger, P., Bauer, A., Elsharawy, A., Haas, J., Backes, C., Wendschlag, A., Giese, N., Tjaden, C., Ott, K., Werner, J., Hackert, T., Ruprecht, K., Huwer, H., Huebers, J., Jacobs, G., Rosenstiel, P., Dommisch, H., Schaefer, A., Müller-Quernheim, J., Wullich, B., Keck, B., Graf, N., Reichrath, J., Vogel, B., Nebel, A., Jager, S. U, Staehler, P., Amarantos, I., Boisguerin, V., Staehler, C., Beier, M., Scheffler, M., Büchler, M. W, Wischhusen, J., Haeusler, S. F M, Dietl, J., Hofmann, S., Lenhof, H., Schreiber, S., Katus, H. A, Rottbauer, W., Meder, B., Hoheisel, J. D, Franke, A., & Meese, E. Nature methods, 8:841–843, September, 2011.
doi  abstract   bibtex   
In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.
@Article{Keller2011,
  author          = {Keller, Andreas and Leidinger, Petra and Bauer, Andrea and Elsharawy, Abdou and Haas, Jan and Backes, Christina and Wendschlag, Anke and Giese, Nathalia and Tjaden, Christine and Ott, Katja and Werner, Jens and Hackert, Thilo and Ruprecht, Klemens and Huwer, Hanno and Huebers, Junko and Jacobs, Gunnar and Rosenstiel, Philip and Dommisch, Henrik and Schaefer, Arne and Müller-Quernheim, Joachim and Wullich, Bernd and Keck, Bastian and Graf, Norbert and Reichrath, Joerg and Vogel, Britta and Nebel, Almut and Jager, Sven U and Staehler, Peer and Amarantos, Ioannis and Boisguerin, Valesca and Staehler, Cord and Beier, Markus and Scheffler, Matthias and Büchler, Markus W and Wischhusen, Joerg and Haeusler, Sebastian F M and Dietl, Johannes and Hofmann, Sylvia and Lenhof, Hans-Peter and Schreiber, Stefan and Katus, Hugo A and Rottbauer, Wolfgang and Meder, Benjamin and Hoheisel, Joerg D and Franke, Andre and Meese, Eckart},
  title           = {Toward the blood-borne miRNome of human diseases.},
  journal         = {Nature methods},
  year            = {2011},
  volume          = {8},
  pages           = {841--843},
  month           = sep,
  issn            = {1548-7105},
  abstract        = {In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.},
  chemicals       = {MicroRNAs},
  citation-subset = {IM},
  completed       = {2011-12-23},
  country         = {United States},
  doi             = {10.1038/nmeth.1682},
  issn-linking    = {1548-7091},
  issue           = {10},
  keywords        = {Disease, genetics; Gene Expression Profiling; Genetic Variation, genetics; Humans; MicroRNAs, blood, genetics; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction},
  nlm-id          = {101215604},
  owner           = {NLM},
  pii             = {nmeth.1682},
  pmid            = {21892151},
  pubmodel        = {Electronic},
  pubstatus       = {epublish},
  revised         = {2017-02-20},
}

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