Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients

Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients. Keller, A., Ludwig, N., Fehlmann, T., Kahraman, M., Backes, C., Kern, F., Vogelmeier, C. F, Diener, C., Fischer, U., Biertz, F., Herr, C., Jörres, R. A, Lenhof, H., Bals, R., & Meese, E. Cells, 8:1162, Multidisciplinary Digital Publishing Institute, September, 2019.
doi abstract bibtex

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study “COPD and SYstemic consequences-COmorbidities NETwork”(COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n= 53) and patients that survived this period (n= 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients.

@Article{Keller2019,
  author       = {Andreas Keller and Nicole Ludwig and Tobias Fehlmann and Mustafa Kahraman and Christina Backes and Fabian Kern and Claus F Vogelmeier and Caroline Diener and Ulrike Fischer and Frank Biertz and Christian Herr and Rudolf A Jörres and Hans-Peter Lenhof and Robert Bals and Eckart Meese},
  title        = {Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients},
  journal      = {Cells},
  publisher    = {Multidisciplinary Digital Publishing Institute},
  year         = {2019},
  volume       = {8},
  issue        = {10},
  pages        = {1162},
  issn         = {1162},
  issn-linking = {1162},
  month        = sep,
  abstract     = {Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study “COPD and SYstemic consequences-COmorbidities NETwork”(COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n= 53) and patients that survived this period (n= 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients.},
  doi          = {10.3390/cells8101162},
  pii          = {10.3390/cells8101162},
}

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