Computational simulations of magnetic particle capture in simplified and realistic arterial flows: Towards optimized magnetic drug targeting. Kenjeres, S. & Cohen Stuart, D. In IFMBE Proceedings, volume 25, 2009.
abstract   bibtex   
In this paper we report on a newly developed method for investigations of the magnetic particles distributions carried by air or by blood inside the human body - aiming for detailed insights into capturing efficiency for different configurations of the imposed magnetic fields. First, a newly developed algorithm for particle tracking in complex non-structured numerical mesh is validated on generic configurations - a simple flow in a horizontal cylinder and in a 90? bend cylinder - for which analytical solutions or experimental and numerical studies were reported in literature. This extensive validation proved accuracy and efficiency of the proposed method. Then, potentials of the proposed method are demonstrated on the specific patient based arterial geometry (a left coronary artery, LCA) where the cumulative deposition efficiency is calculated for different magnetic field orientations. It is concluded that the newly developed particle tracking algorithm for magnetic particles proved to be powerful tool for predictions of capturing efficiencies in complex geometries. As such, it can be used for pre-design, testing, application and optimization of the magnetic drug targeting approach for specific patient conditions.
@inProceedings{
 title = {Computational simulations of magnetic particle capture in simplified and realistic arterial flows: Towards optimized magnetic drug targeting},
 type = {inProceedings},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {[Magnetic drug targeting, Magnetic field, Magnetiz},
 volume = {25},
 issue = {4},
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 abstract = {In this paper we report on a newly developed method for investigations of the magnetic particles distributions carried by air or by blood inside the human body - aiming for detailed insights into capturing efficiency for different configurations of the imposed magnetic fields. First, a newly developed algorithm for particle tracking in complex non-structured numerical mesh is validated on generic configurations - a simple flow in a horizontal cylinder and in a 90? bend cylinder - for which analytical solutions or experimental and numerical studies were reported in literature. This extensive validation proved accuracy and efficiency of the proposed method. Then, potentials of the proposed method are demonstrated on the specific patient based arterial geometry (a left coronary artery, LCA) where the cumulative deposition efficiency is calculated for different magnetic field orientations. It is concluded that the newly developed particle tracking algorithm for magnetic particles proved to be powerful tool for predictions of capturing efficiencies in complex geometries. As such, it can be used for pre-design, testing, application and optimization of the magnetic drug targeting approach for specific patient conditions.},
 bibtype = {inProceedings},
 author = {Kenjeres, S. and Cohen Stuart, D.C.},
 booktitle = {IFMBE Proceedings}
}

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