Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: Separation of blood volume and magnetic susceptibility effects. Kennan, R. P., Scanley, B. E., & Gore, J. C. Magnetic Resonance in Medicine, 37(6):953--956, 1997.
Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: Separation of blood volume and magnetic susceptibility effects [link]Paper  doi  abstract   bibtex   
An NMR method is presented for separating blood volume and magnetic susceptibility effects in response to respiratory challenges such as hypoxia and hyperoxia. The technique employs high susceptibility contrast agents to enhance blood volume induced signal changes. The results show that for a rat model the dominant source of signal variation upon changing breathing gas from 100% oxygen to 10% oxygen/90% nitrogen is the change in blood magnetic susceptibility associated with the BOLD effect. The results imply that signal changes associated with respiratory challenges can be regarded as indicators of local blood oxygenation in vivo.
@article{kennan_physiologic_1997,
	title = {Physiologic basis for {BOLD} {MR} signal changes due to hypoxia/hyperoxia: {Separation} of blood volume and magnetic susceptibility effects},
	volume = {37},
	shorttitle = {Physiologic basis for {BOLD} {MR} signal changes due to hypoxia/hyperoxia},
	url = {http://dx.doi.org/10.1002/mrm.1910370621},
	doi = {10.1002/mrm.1910370621},
	abstract = {An NMR method is presented for separating blood volume and magnetic susceptibility effects in response to respiratory challenges such as hypoxia and hyperoxia. The technique employs high susceptibility contrast agents to enhance blood volume induced signal changes. The results show that for a rat model the dominant source of signal variation upon changing breathing gas from 100\% oxygen to 10\% oxygen/90\% nitrogen is the change in blood magnetic susceptibility associated with the BOLD effect. The results imply that signal changes associated with respiratory challenges can be regarded as indicators of local blood oxygenation in vivo.},
	number = {6},
	urldate = {2009-01-13},
	journal = {Magnetic Resonance in Medicine},
	author = {Kennan, Richard P. and Scanley, B. Ellen and Gore, John C.},
	year = {1997},
	keywords = {contrastagent, haemodynamics, CBV, hyperoxia},
	pages = {953--956},
	file = {kennan1997.pdf:/Users/nickb/Zotero/storage/TMTQTRCP/kennan1997.pdf:application/pdf;Wiley InterScience \:\: JOURNALS \:\: Magnetic Resonance in Medicine:/Users/nickb/Zotero/storage/V68CHAN9/abstract.html:text/html}
}
Downloads: 0